Julia Derk
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View article: Formation and function of the meningeal arachnoid barrier around the developing mouse brain
Formation and function of the meningeal arachnoid barrier around the developing mouse brain Open
View article: ‘Formation and function of the meninges arachnoid barrier around the developing brain’
‘Formation and function of the meninges arachnoid barrier around the developing brain’ Open
Barriers at the level of the brain endothelium, choroid plexus, and meninges strictly regulate movement of molecules and cells into and out of the central nervous system (CNS). In contrast to the blood-brain barrier and choroid plexus epit…
View article: Formation and Function of the Meninges Arachnoid Barrier Around the Developing Brain
Formation and Function of the Meninges Arachnoid Barrier Around the Developing Brain Open
View article: Corrigendum: Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease
Corrigendum: Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease Open
[This corrects the article DOI: 10.3389/fncel.2021.703944.].
View article: Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease
Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease Open
The meninges are the fibrous covering of the central nervous system (CNS) which contain vastly heterogeneous cell types within its three layers (dura, arachnoid, and pia). The dural compartment of the meninges, closest to the skull, is pre…
View article: A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis
A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis Open
View article: The Receptor for Advanced Glycation End Products (RAGE) and DIAPH1: Implications for vascular and neuroinflammatory dysfunction in disorders of the central nervous system
The Receptor for Advanced Glycation End Products (RAGE) and DIAPH1: Implications for vascular and neuroinflammatory dysfunction in disorders of the central nervous system Open
View article: Diaphanous 1 (DIAPH1) is Highly Expressed in the Aged Human Medial Temporal Cortex and Upregulated in Myeloid Cells During Alzheimer’s Disease
Diaphanous 1 (DIAPH1) is Highly Expressed in the Aged Human Medial Temporal Cortex and Upregulated in Myeloid Cells During Alzheimer’s Disease Open
Our findings localize DIAPH1 particularly to myeloid cells in the CNS, especially in AD in the locations of lipid droplet accumulation, thereby implicating RAGE-DIAPH1 signaling in dysregulated lipid metabolism and morphological changes of…
View article: The receptor for advanced glycation endproducts is a mediator of toxicity by IAPP and other proteotoxic aggregates: Establishing and exploiting common ground for novel amyloidosis therapies
The receptor for advanced glycation endproducts is a mediator of toxicity by IAPP and other proteotoxic aggregates: Establishing and exploiting common ground for novel amyloidosis therapies Open
Proteotoxicity plays a key role in many devastating human disorders, including Alzheimer's, Huntington's and Parkinson's diseases; type 2 diabetes; systemic amyloidosis; and cardiac dysfunction, to name a few. The cellular mechanisms of pr…
View article: RAGE binds preamyloid IAPP intermediates and mediates pancreatic β cell proteotoxicity
RAGE binds preamyloid IAPP intermediates and mediates pancreatic β cell proteotoxicity Open
Islet amyloidosis is characterized by the aberrant accumulation of islet amyloid polypeptide (IAPP) in pancreatic islets, resulting in β cell toxicity, which exacerbates type 2 diabetes and islet transplant failure. It is not fully clear h…
View article: The Receptor for Advanced Glycation Endproducts (RAGE) and Mediation of Inflammatory Neurodegeneration
The Receptor for Advanced Glycation Endproducts (RAGE) and Mediation of Inflammatory Neurodegeneration Open
The Receptor for Advanced Glycation Endproducts (RAGE) is an immunoglobulin-type, transmembrane receptor that is expressed on numerous cell types in the Central Nervous System (CNS) and periphery, such as neurons, astrocytes, microglia, mo…
View article: Award Winners and Abstracts of the 30th Anniversary Symposium of The Protein Society, Baltimore, MD, July 16–19, 2016
Award Winners and Abstracts of the 30th Anniversary Symposium of The Protein Society, Baltimore, MD, July 16–19, 2016 Open
the combinatorial complexity of simultaneously occurring histone modifications, identifying thousands of uniquely modified histone H3 forms, the significance of which is the focus of current research interest (e.g.combinatorial Histone Cod…
View article: P3‐036: Rage signal transduction and implications for neuroinflammation in Alzheimer's disease
P3‐036: Rage signal transduction and implications for neuroinflammation in Alzheimer's disease Open
The risk of developing Alzheimer's disease (AD) is magnified in individuals with metabolic dysfunction, specifically obesity and type 2 diabetes. In cases of insulin deficiency or resistance, elevated and fluctuating levels of blood glucos…