Julia Dietz
YOU?
Author Swipe
View article: Associations between past infectious mononucleosis diagnosis and 47 inflammatory and vascular stress biomarkers
Associations between past infectious mononucleosis diagnosis and 47 inflammatory and vascular stress biomarkers Open
Infectious mononucleosis (IM), predominantly caused by primary Epstein-Barr virus (EBV) infection, is a common disease in adolescents and young adults. EBV infection is nearly ubiquitous globally. Although primary EBV infection is asymptom…
View article: Risk of infectious mononucleosis is not associated with prior infection morbidity
Risk of infectious mononucleosis is not associated with prior infection morbidity Open
Background The probability of presenting with infectious mononucleosis (IM) upon primary Epstein–Barr virus infection increases dramatically at the start of puberty. Aiming to understand why that is, we assessed whether the number of infec…
View article: Evaluating Medical Image Segmentation Models Using Augmentation
Evaluating Medical Image Segmentation Models Using Augmentation Open
Background: Medical image segmentation is an essential step in both clinical and research applications, and automated segmentation models—such as TotalSegmentator—have become ubiquitous. However, robust methods for validating the accuracy …
View article: Detection of Hepatitis C Virus Infection from Patient Sera in Cell Culture Using Semi-Automated Image Analysis
Detection of Hepatitis C Virus Infection from Patient Sera in Cell Culture Using Semi-Automated Image Analysis Open
The study of hepatitis C virus (HCV) replication in cell culture is mainly based on cloned viral isolates requiring adaptation for efficient replication in Huh7 hepatoma cells. The analysis of wild-type (WT) isolates was enabled by the exp…
View article: Detection of Hepatitis C Virus Infection from Patient Sera in Cell Culture Using Semi-Automated Image Analysis
Detection of Hepatitis C Virus Infection from Patient Sera in Cell Culture Using Semi-Automated Image Analysis Open
The study of hepatitis C virus (HCV) replication in cell culture is mainly based on cloned viral isolates requiring adaptation for efficient replication in Huh7 hepatoma cells. The analysis of wild type (WT) isolates has been enabled by ex…
View article: The prognostic relevance of pleural effusion in patients with COVID-19 - A German multicenter study
The prognostic relevance of pleural effusion in patients with COVID-19 - A German multicenter study Open
Pleural effusion is present in a significant portion of COVID-19 patients and independently predicts increased 30-day mortality, underscoring its value as a prognostic marker. Its identification, irrespective of volume or density, should b…
View article: Reply to: “Unlocking hope: HCV re-treatment strategy for patients with active hepatocellular carcinoma”
Reply to: “Unlocking hope: HCV re-treatment strategy for patients with active hepatocellular carcinoma” Open
View article: Enhancing Forensic Diagnostics: Structured Reporting of Post-Mortem CT versus Autopsy for Laryngohyoid Complex Fractures in Strangulation
Enhancing Forensic Diagnostics: Structured Reporting of Post-Mortem CT versus Autopsy for Laryngohyoid Complex Fractures in Strangulation Open
Background: The purpose of this study was to establish a standardized structured workflow to compare findings from high-resolution, optimized reconstructions from post-mortem computed tomography (pmCT) with autopsy results in the detection…
View article: Impaired <scp>HBsAg</scp> release and antiproliferative/antioxidant cell regulation by <scp>HBeAg</scp>‐negative patient isolates reflects an evolutionary process
Impaired <span>HBsAg</span> release and antiproliferative/antioxidant cell regulation by <span>HBeAg</span>‐negative patient isolates reflects an evolutionary process Open
Background The hepatitis B e antigen (HBeAg)‐negative infection Phase 3 is characterized by no or minimal signs of hepatic inflammation and the absence of hepatic fibrosis. However, underlying molecular mechanisms leading to this benign ph…
View article: Value of MRI - T2 Mapping to Differentiate Clinically Significant Prostate Cancer
Value of MRI - T2 Mapping to Differentiate Clinically Significant Prostate Cancer Open
View article: Rare HCV subtypes and retreatment outcomes in a cohort of European DAA-experienced patients
Rare HCV subtypes and retreatment outcomes in a cohort of European DAA-experienced patients Open
Data on the prevalence and characteristics of rare HCV genotypes (GT) in larger cohorts are still scarce. This study found low rates of rare HCV GTs among European HCV-infected patients. In direct-acting antiviral (DAA)-failure patients, r…
View article: Real-world effectiveness of voxilaprevir/velpatasvir/sofosbuvir in patients following DAA failure
Real-world effectiveness of voxilaprevir/velpatasvir/sofosbuvir in patients following DAA failure Open
View article: Generation of two hiPSCs lines of two patients carrying truncating mutations in the dimerization domain of filamin C
Generation of two hiPSCs lines of two patients carrying truncating mutations in the dimerization domain of filamin C Open
Here we introduce the human induced pluripotent stem cell lines (hiPSCs), HIMRi004-A and HIMRi005-A from dermal fibroblasts of a 48-year-old female (HIMRi004-A) carrying missense mutation that translate to the first described filamin C iso…
View article: Lightweight Techniques to Improve Generalization and Robustness of U-Net Based Networks for Pulmonary Lobe Segmentation
Lightweight Techniques to Improve Generalization and Robustness of U-Net Based Networks for Pulmonary Lobe Segmentation Open
Lung lobe segmentation in chest CT is relevant to a wide range of clinical applications. However, existing segmentation pipelines often exhibit vulnerabilities and performance degradations when applied to external datasets. This is usually…
View article: Primary Biliary Cholangitis (PBC)-Autoimmune Hepatitis (AIH) Variant Syndrome: Clinical Features, Response to Therapy and Long-Term Outcome
Primary Biliary Cholangitis (PBC)-Autoimmune Hepatitis (AIH) Variant Syndrome: Clinical Features, Response to Therapy and Long-Term Outcome Open
Introduction: Standardization of diagnostic criteria of autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) variant syndrome (AIH-PBC VS) has not been achieved so far and evidence-based recommendations for monitoring and treat…
View article: Co-Occurring Alterations in Multiple Tumor Suppressor Genes Are Associated With Worse Outcomes in Patients With EGFR-Mutant Lung Cancer
Co-Occurring Alterations in Multiple Tumor Suppressor Genes Are Associated With Worse Outcomes in Patients With EGFR-Mutant Lung Cancer Open
View article: Is Olfactory Testing a Useful Diagnostic Tool to Identify SARS-CoV-2 Infections Early? A Cross-Sectional and Longitudinal Analysis
Is Olfactory Testing a Useful Diagnostic Tool to Identify SARS-CoV-2 Infections Early? A Cross-Sectional and Longitudinal Analysis Open
BACKGROUND: Genesis and the prognostic value of olfactory dysfunction (OD) in COVID-19 remain partially described. The objective of our study was to characterize OD during SARS-CoV-2 infection and to examine whether testing of OD may be a …
View article: Expanding epidemic of recently acquired HCV in HIV-coinfected patients over a period of 10 years
Expanding epidemic of recently acquired HCV in HIV-coinfected patients over a period of 10 years Open
View article: Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals
Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals Open
View article: Hepatic sarcoidosis: Clinical characteristics and outcome
Hepatic sarcoidosis: Clinical characteristics and outcome Open
View article: SHARED: An International Collaboration to Unravel Hepatitis C Resistance
SHARED: An International Collaboration to Unravel Hepatitis C Resistance Open
The advent of direct-acting antivirals (DAAs) has transformed the treatment landscape of hepatitis C [...]
View article: Epistatic interactions promote persistence of NS3-Q80K in HCV infection by compensating for protein folding instability
Epistatic interactions promote persistence of NS3-Q80K in HCV infection by compensating for protein folding instability Open
The Q80K polymorphism in the NS3-4A protease of the hepatitis C virus is associated with treatment failure of direct-acting antiviral agents. This polymorphism is highly prevalent in genotype 1a infections and stably transmitted between ho…
View article: Reply to: “Glecaprevir/pibrentasvir + sofosbuvir + ribavirin offers high cure rate for hepatitis C virus retreatment in real-world settings”
Reply to: “Glecaprevir/pibrentasvir + sofosbuvir + ribavirin offers high cure rate for hepatitis C virus retreatment in real-world settings” Open
View article: Not uncommon: HBV genotype G co‐infections among healthy European HBV carriers with genotype A and E infection
Not uncommon: HBV genotype G co‐infections among healthy European HBV carriers with genotype A and E infection Open
Background & Aims HBV genotype G (HBV/G) is mainly found in co‐infections with other HBV genotypes and was identified as an independent risk factor for liver fibrosis. This study aimed to analyse the prevalence of HBV/G co‐infections in he…
View article: Quadruple mutation GCAC1809-1812TTCT acts as a biomarker in healthy European HBV carriers
Quadruple mutation GCAC1809-1812TTCT acts as a biomarker in healthy European HBV carriers Open
Many mutation analyses of the HBV genome have been performed in the search for new prognostic markers. However, the Kozak sequence preceding precore was covered only infrequently in these analyses. In this study, the HBV core promoter/prec…
View article: Hepatitis C Clearance by Direct-Acting Antivirals Impacts Glucose and Lipid Homeostasis
Hepatitis C Clearance by Direct-Acting Antivirals Impacts Glucose and Lipid Homeostasis Open
Background: Chronic hepatitis C virus (HCV) infections are causally linked with metabolic comorbidities such as insulin resistance, hepatic steatosis, and dyslipidemia. However, the clinical impact of HCV eradication achieved by direct-act…
View article: Not uncommon: HBV genotype g co-infection in HBeAg-negative chronic HBV infected patients
Not uncommon: HBV genotype g co-infection in HBeAg-negative chronic HBV infected patients Open
View article: Acute hepatitis C virus infection: a prospective ten-year observational study of HCV-mono and HCV/HIV-coinfected patients
Acute hepatitis C virus infection: a prospective ten-year observational study of HCV-mono and HCV/HIV-coinfected patients Open
View article: Virological characterization of patients with chronic hepatitis C and failure to a glecaprevir/pibrentasvir or voxilaprevir/ velpatasvir/sofosbuvir treatment in the international shared collaboration
Virological characterization of patients with chronic hepatitis C and failure to a glecaprevir/pibrentasvir or voxilaprevir/ velpatasvir/sofosbuvir treatment in the international shared collaboration Open
View article: Prevalence of resistance-associated substitutions and retreatment of patients failing a glecaprevir/pibrentasvir regimen
Prevalence of resistance-associated substitutions and retreatment of patients failing a glecaprevir/pibrentasvir regimen Open
Objectives To investigate resistance-associated substitutions (RASs) as well as retreatment efficacies in a large cohort of European patients with failure of glecaprevir/pibrentasvir. Methods Patients were identified from three European Re…