Julia E. Blower
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View article: In Vivo Trafficking of the Anticancer Drug Tris(8-Quinolinolato) Gallium (III) (KP46) by Gallium-68/67 PET/SPECT Imaging
In Vivo Trafficking of the Anticancer Drug Tris(8-Quinolinolato) Gallium (III) (KP46) by Gallium-68/67 PET/SPECT Imaging Open
KP46 (tris(hydroxyquinolinato)gallium(III)) is an experimental, orally administered anticancer drug. Its absorption, delivery to tumours, and mode of action are poorly understood. We aimed to gain insight into these issues using gallium-67…
View article: An indium-111-labelled membrane-targeted peptide for cell tracking with radionuclide imaging
An indium-111-labelled membrane-targeted peptide for cell tracking with radionuclide imaging Open
An indium-111-labelled peptide binds to myeloma cells, enabling SPECT imaging of myeloma cell accumulation in lungs after intravenous administration. This is the first report of a radiolabelled cell-membrane binding peptide for cell tracki…
View article: Non-invasive radionuclide imaging of trace metal trafficking in health and disease: “PET metallomics”
Non-invasive radionuclide imaging of trace metal trafficking in health and disease: “PET metallomics” Open
Radioactive isotopes of elements from across the periodic table allow for non-invasive imaging of essential metals in health and disease.
View article: Targeted Auger electron-emitter therapy: Radiochemical approaches for thallium-201 radiopharmaceuticals
Targeted Auger electron-emitter therapy: Radiochemical approaches for thallium-201 radiopharmaceuticals Open
Decay of [201Tl]Tl(III) in proximity to DNA causes DNA damage. Iodobeads provide a simple, mild method to convert thallium-201 from a 1+ to 3+ oxidation state and [201Tl]Tl(III) can be chelated by DOTA with moderate stability. Of the well-…
View article: The Hantzsch reaction for nitrogen-13 PET: preparation of [<sup>13</sup>N]nifedipine and derivatives
The Hantzsch reaction for nitrogen-13 PET: preparation of [<sup>13</sup>N]nifedipine and derivatives Open
The Hantzsch reaction was adapted to allow the rapid radiosynthesis of 13N-labelled 1,4-dihydropyridines, including [13N]nifedipine, for preclinical PET imaging.
View article: <i>In vivo</i> trafficking of a tumor-targeting IgE antibody: molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart
<i>In vivo</i> trafficking of a tumor-targeting IgE antibody: molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart Open
IgE antibodies elicit powerful immune responses, recruiting effector cells to tumors more efficiently and with greater cytotoxicity than IgG antibodies. Consequently, IgE antibodies are a promising alternative to conventional IgG-based the…
View article: Protocols for Dual Tracer PET/SPECT Preclinical Imaging
Protocols for Dual Tracer PET/SPECT Preclinical Imaging Open
Suitable combinations of injection sequence and imaging sequence can be devised to meet specific experimental multi-tracer imaging needs, with only minor or insignificant effects of each radionuclide on the scan of the other.
View article: Manipulating the In Vivo Behaviour of 68Ga with Tris(Hydroxypyridinone) Chelators: Pretargeting and Blood Clearance
Manipulating the In Vivo Behaviour of 68Ga with Tris(Hydroxypyridinone) Chelators: Pretargeting and Blood Clearance Open
Pretargeting is widely explored in immunoPET as a strategy to reduce radiation exposure of non-target organs and allow the use of short-lived radionuclides that would not otherwise be compatible with the slow pharmacokinetic profiles of an…
View article: Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models
Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models Open
Metastasis is responsible for most cancer deaths. Despite extensive research, the mechanistic understanding of the complex processes governing metastasis remains incomplete. In vivo models are paramount for metastasis research, but require…
View article: Convergent synthesis of 13N-labelled Peptidic structures using aqueous [13N]NH3
Convergent synthesis of 13N-labelled Peptidic structures using aqueous [13N]NH3 Open
We have developed a one-pot method that opens up new routes to radiolabel complex, peptidic molecules with 13N using aqueous [13N]NH3 as a synthetic precursor.