Julia E. Kline
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View article: The mitophagy receptor BNIP3L/Nix coordinates nuclear calcium signaling to modulate the muscle phenotype
The mitophagy receptor BNIP3L/Nix coordinates nuclear calcium signaling to modulate the muscle phenotype Open
Mitochondrial quality control is critical in muscle to ensure contractile and metabolic function. BNIP3L/Nix is a BCL2 member, a mitophagy receptor, and has been implicated in muscle atrophy. Human genome-wide association studies (GWAS) su…
View article: Development and evaluation of a BCI-neurofeedback system with real-time EEG detection and electrical stimulation assistance during motor attempt for neurorehabilitation of children with cerebral palsy
Development and evaluation of a BCI-neurofeedback system with real-time EEG detection and electrical stimulation assistance during motor attempt for neurorehabilitation of children with cerebral palsy Open
In the realm of motor rehabilitation, Brain-Computer Interface Neurofeedback Training (BCI-NFT) emerges as a promising strategy. This aims to utilize an individual’s brain activity to stimulate or assist movement, thereby strengthening sen…
View article: Corpus Callosum Abnormalities at Term-Equivalent Age Are Associated with Language Development at 2 Years’ Corrected Age in Infants Born Very Preterm
Corpus Callosum Abnormalities at Term-Equivalent Age Are Associated with Language Development at 2 Years’ Corrected Age in Infants Born Very Preterm Open
We studied the effect of microstructural abnormalities in the corpus callosum on language development in 348 infants born very prematurely. We discovered that the fractional anisotropy of the corpus callosum anterior midbody was a signific…
View article: Structural connectivity at term equivalent age and language in preterm children at 2 years corrected
Structural connectivity at term equivalent age and language in preterm children at 2 years corrected Open
We previously reported interhemispheric structural hyperconnectivity bypassing the corpus callosum in children born extremely preterm (<28 weeks) versus term children. This increased connectivity was positively associated with language …
View article: Corpus callosum abnormalities at term-equivalent age are associated with language development at two years corrected age in infants born very preterm
Corpus callosum abnormalities at term-equivalent age are associated with language development at two years corrected age in infants born very preterm Open
We studied the impact of microstructural abnormalities in the corpus callosum on language development in 348 infants born very prematurely. We discovered that the fractional anisotropy of the corpus callosum anterior midbody was a signific…
View article: Children With Bilateral Cerebral Palsy Exhibit Bimanual Asymmetric Motor Deficits and EEG Evidence of Dominant Sensorimotor Hemisphere Overreliance During Reaching
Children With Bilateral Cerebral Palsy Exhibit Bimanual Asymmetric Motor Deficits and EEG Evidence of Dominant Sensorimotor Hemisphere Overreliance During Reaching Open
Background Reaching is a fundamental motor skill often impaired in cerebral palsy (CP). Studies on manual function, intervention, and underlying brain mechanisms largely focus on unilateral CP. This first electroencephalography (EEG) evalu…
View article: The mitophagy receptor BNIP3L/Nix coordinates nuclear calcium signaling to modulate the muscle phenotype
The mitophagy receptor BNIP3L/Nix coordinates nuclear calcium signaling to modulate the muscle phenotype Open
Mitochondrial quality control is critical in muscle to ensure both contractile and metabolic function. Nix is a BCL-2 family member, mitophagy receptor, and has been implicated in muscle atrophy. Human GWAS suggests altered Nix expression …
View article: Brain microstructural antecedents of visual difficulties in infants born very preterm
Brain microstructural antecedents of visual difficulties in infants born very preterm Open
Infants born very preterm (VPT) are at risk of later visual problems. Although neonatal screening can identify ophthalmologic abnormalities, subtle perinatal brain injury and/or delayed brain maturation may be significant contributors to c…
View article: Cover Image
Cover Image Open
COVER ILLUSTRATION Corpus callosum fiber tractography in sagittal orientation derived using constrained spherical deconvolution (CSD) modelling. CSD is an advanced diffusion MRI technique that partially overcomes limitations of the diffusi…
View article: Early micro‐ and macrostructure of sensorimotor tracts and development of cerebral palsy in high risk infants
Early micro‐ and macrostructure of sensorimotor tracts and development of cerebral palsy in high risk infants Open
Infants born very preterm (VPT) are at high risk of motor impairments such as cerebral palsy (CP), and diagnosis can take 2 years. Identifying in vivo determinants of CP could facilitate presymptomatic detection and targeted intervention. …
View article: Microstructural Measures of the Inferior Longitudinal Fasciculus Predict Later Cognitive and Language Development in Infants Born With Extremely Low Birth Weight
Microstructural Measures of the Inferior Longitudinal Fasciculus Predict Later Cognitive and Language Development in Infants Born With Extremely Low Birth Weight Open
Objective: Extremely preterm children are at high risk for adverse neurodevelopmental outcomes. Identifying predictors of discrete developmental outcomes early in life would allow for targeted neuroprotective therapies when neuroplasticity…
View article: Diffusion MRI Microstructural Abnormalities at Term-Equivalent Age Are Associated with Neurodevelopmental Outcomes at 3 Years of Age in Very Preterm Infants
Diffusion MRI Microstructural Abnormalities at Term-Equivalent Age Are Associated with Neurodevelopmental Outcomes at 3 Years of Age in Very Preterm Infants Open
We identified widespread microstructural white matter abnormalities in very preterm infants at term that were significantly associated with cognitive and motor development at 3 years' corrected age.
View article: Automated brain morphometric biomarkers from MRI at term predict motor development in very preterm infants
Automated brain morphometric biomarkers from MRI at term predict motor development in very preterm infants Open
Very preterm infants are at high risk for motor impairments. Early intervention can improve outcomes in this cohort, but it would be most effective if clinicians could accurately identify the highest risk infants early. A number of biomark…
View article: Diffuse white matter abnormality in very preterm infants reflects reduced brain network efficiency
Diffuse white matter abnormality in very preterm infants reflects reduced brain network efficiency Open
Between 50-80% of very preterm infants (≤32 weeks gestational age) exhibit increased white matter signal intensity on T2 MRI at term-equivalent age, known as diffuse white matter abnormality (DWMA). A few studies have linked DWMA with micr…
View article: Early cortical maturation predicts neurodevelopment in very preterm infants
Early cortical maturation predicts neurodevelopment in very preterm infants Open
Objective To evaluate the ability of four objectively defined, cortical maturation features—surface area, gyrification index, sulcal depth and curvature—from structural MRI at term-equivalent age (TEA) to independently predict cognitive an…
View article: Cortical Spectral Activity and Connectivity during Active and Viewed Arm and Leg Movement
Cortical Spectral Activity and Connectivity during Active and Viewed Arm and Leg Movement Open
Active and viewed limb movement activate many similar neural pathways, however, to date most comparison studies have focused on subjects making small, discrete movements of the hands and feet. The purpose of this study was to determine if …
View article: Independent Component Analysis of Gait-Related Movement Artifact Recorded using EEG Electrodes during Treadmill Walking
Independent Component Analysis of Gait-Related Movement Artifact Recorded using EEG Electrodes during Treadmill Walking Open
There has been a recent surge in the use of electroencephalography (EEG) as a tool for mobile brain imaging due to its portability and fine time resolution. When EEG is combined with independent component analysis (ICA) and source localiza…