Julia E. Manning
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View article: Multiomics identifies tumor-intrinsic SREBP1 driving immune exclusion in hepatocellular carcinoma
Multiomics identifies tumor-intrinsic SREBP1 driving immune exclusion in hepatocellular carcinoma Open
Immune checkpoint inhibitors (ICI) have improved patient outcomes in hepatocellular carcinoma (HCC); however, most patients do not experience durable benefit. The non-T cell-inflamed tumor microenvironment, characterized by limited CD8 + T…
View article: Type-H endothelial cell protein Clec14a orchestrates osteoblast activity during trabecular bone formation and patterning
Type-H endothelial cell protein Clec14a orchestrates osteoblast activity during trabecular bone formation and patterning Open
Type-H capillary endothelial cells control bone formation during embryogenesis and postnatal growth but few signalling mechanisms underpinning this influence have been characterised. Here, we identify a highly expressed type-H endothelial …
View article: Rejuvenation of leukocyte trafficking in aged mice through PEPITEM intervention
Rejuvenation of leukocyte trafficking in aged mice through PEPITEM intervention Open
Inflammageing leads to uncontrolled leukocyte trafficking in response to inflammatory insults. Here, we used a zymosan-induced peritonitis mouse model on inflammation to investigate the role of the PEPITEM pathway on leukocyte migration in…
View article: Polymyalgia rheumatica shows metabolomic alterations that are further altered by glucocorticoid treatment: Identification of metabolic correlates of fatigue
Polymyalgia rheumatica shows metabolomic alterations that are further altered by glucocorticoid treatment: Identification of metabolic correlates of fatigue Open
PMR and GCA alter the metabolite signature. In PMR, this is further altered by glucocorticoid therapy. Treatment-induced metabolite changes were linked to measures of inflammation (CRP, pain and stiffness), but not to fatigue. Furthermore,…
View article: Interplay in galectin expression predicts patient outcomes in a spatially restricted manner in PDAC
Interplay in galectin expression predicts patient outcomes in a spatially restricted manner in PDAC Open
In summary, the intricate interplay and cell-specific expression patterns of galectins within the PDAC tissue, particularly the inverse correlation between Gal-1 and Gal-4 in ducts and its significant association with patient survival, hig…
View article: Insights Into Leukocyte Trafficking in Inflammatory Arthritis – Imaging the Joint
Insights Into Leukocyte Trafficking in Inflammatory Arthritis – Imaging the Joint Open
The inappropriate accumulation and activation of leukocytes is a shared pathological feature of immune-mediated inflammatory diseases (IMIDs), such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Cellular accumulation is theref…
View article: Podoplanin regulates the migration of mesenchymal stromal cells and their interaction with platelets
Podoplanin regulates the migration of mesenchymal stromal cells and their interaction with platelets Open
Mesenchymal stromal cells (MSC) up-regulate podoplanin at sites of infection, chronic inflammation, and cancer. We investigated the functional consequences of podoplanin expression on the migratory potential of MSC and their interactions w…