Julia E. Prier
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View article: KDM6B-dependent chromatin remodeling underpins effective virus-specific CD8+ T cell differentiation
KDM6B-dependent chromatin remodeling underpins effective virus-specific CD8+ T cell differentiation Open
Naive CD8+ T cell activation results in an autonomous program of cellular proliferation and differentiation. However, the mechanisms that underpin this process are unclear. Here, we profile genome-wide changes in chromatin accessibility, g…
View article: KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8<sup>+</sup>T cell differentiation
KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8<sup>+</sup>T cell differentiation Open
SUMMARY Naive CD8 + T cell activation results in an autonomous program of cellular proliferation and differentiation. However, the mechanisms that underpin this process are unclear. Here we profiled genome-wide changes in chromatin accessi…
View article: Early T-BET Expression Ensures an Appropriate CD8+ Lineage–Specific Transcriptional Landscape after Influenza A Virus Infection
Early T-BET Expression Ensures an Appropriate CD8+ Lineage–Specific Transcriptional Landscape after Influenza A Virus Infection Open
Virus infection triggers large-scale changes in the phenotype and function of naive CD8+ T cells, resulting in the generation of effector and memory T cells that are then critical for immune clearance. The T-BOX family of transcription fac…
View article: Peripheral and systemic antigens elicit an expandable pool of resident memory CD8 <sup>+</sup> T cells in the bone marrow
Peripheral and systemic antigens elicit an expandable pool of resident memory CD8 <sup>+</sup> T cells in the bone marrow Open
BM has been put forward as a major reservoir for memory CD8 + T cells. In order to fulfill that function, BM should “store” memory CD8 + T cells, which in biological terms would require these “stored” memory cells to be in disequilibrium w…
View article: CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver
CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver Open
Liver tissue-resident memory T (Trm) cells migrate throughout the sinusoids and are capable of protecting against malaria sporozoite challenge. To gain an understanding of liver Trm cell development, we examined various conditions for thei…
View article: Mouse Norovirus Infection Reduces the Surface Expression of Major Histocompatibility Complex Class I Proteins and Inhibits CD8 <sup>+</sup> T Cell Recognition and Activation
Mouse Norovirus Infection Reduces the Surface Expression of Major Histocompatibility Complex Class I Proteins and Inhibits CD8 <sup>+</sup> T Cell Recognition and Activation Open
Human noroviruses (HuNoVs) are the major cause of nonbacterial gastroenteritis worldwide and impose a great burden on patients and health systems every year. So far, no antiviral treatment or vaccine is available. We show that MNV evades t…
View article: Phospholipase A2 activity during the replication cycle of the flavivirus West Nile virus
Phospholipase A2 activity during the replication cycle of the flavivirus West Nile virus Open
Positive-sense RNA virus intracellular replication is intimately associated with membrane platforms that are derived from host organelles and comprised of distinct lipid composition. For flaviviruses, such as West Nile virus strain Kunjin …
View article: The Host Protein Reticulon 3.1A Is Utilized by Flaviviruses to Facilitate Membrane Remodelling
The Host Protein Reticulon 3.1A Is Utilized by Flaviviruses to Facilitate Membrane Remodelling Open
Flaviviruses are enveloped, positive-sensed single-stranded RNA viruses that remodel host membranes, incorporating both viral and host factors facilitating viral replication. In this study, we identified a key role for the membrane-bending…
View article: Transcriptional Enhancers in the Regulation of T Cell Differentiation
Transcriptional Enhancers in the Regulation of T Cell Differentiation Open
The changes in phenotype and function that characterize the differentiation of naïve T cells to effector and memory states are underscored by large-scale, coordinated, and stable changes in gene expression. In turn, these changes are chore…