Julia Fraser
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View article: The relation of eye movements to the occurrence of freezing of gait in Parkinson’s disease
The relation of eye movements to the occurrence of freezing of gait in Parkinson’s disease Open
Freezing of gait is a debilitating motor symptom in Parkinson's disease that significantly increases fall risk and impairs quality of life. The poorly understood pathophysiology of freezing of gait presents challenges for early prediction …
View article: White matter tract correlations with spoken language in cerebrovascular disease
White matter tract correlations with spoken language in cerebrovascular disease Open
Assessment of spoken language is a promising marker for cognitive impairment in individuals with cerebrovascular disease. However, the underlying neurological basis for spoken language beyond single words and sentences remains poorly defin…
View article: Link among <i>apolipoprotein E</i> E4, gait, and cognition in neurodegenerative diseases: ONDRI study
Link among <i>apolipoprotein E</i> E4, gait, and cognition in neurodegenerative diseases: ONDRI study Open
INTRODUCTION Apolipoprotein E E4 allele ( APOE E4) and slow gait are independently associated with cognitive impairment and dementia. However, it is unknown whether their coexistence is associated with poorer cognitive performance and its …
View article: Association of Dual-Task Gait Cost and White Matter Hyperintensity Burden Poststroke: Results From the ONDRI
Association of Dual-Task Gait Cost and White Matter Hyperintensity Burden Poststroke: Results From the ONDRI Open
Background Acute change in gait speed while performing a mental task [dual-task gait cost (DTC)], and hyperintensity magnetic resonance imaging signals in white matter are both important disability predictors in older individuals with hist…
View article: Cognitive correlates of antisaccade behaviour across multiple neurodegenerative diseases
Cognitive correlates of antisaccade behaviour across multiple neurodegenerative diseases Open
Oculomotor tasks generate a potential wealth of behavioural biomarkers for neurodegenerative diseases. Overlap between oculomotor and disease-impaired circuitry reveals the location and severity of disease processes via saccade parameters …
View article: White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease: results from the Ontario Neurodegenerative Diseases Research Initiative
White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease: results from the Ontario Neurodegenerative Diseases Research Initiative Open
Background and purpose The pathophysiology of Parkinson's disease (PD) negatively affects brain network connectivity, and in the presence of brain white matter hyperintensities (WMHs) cognitive and motor impairments seem to be aggravated. …
View article: Examining the Temporal Stability of Evaluative Attitudes Toward Violence
Examining the Temporal Stability of Evaluative Attitudes Toward Violence Open
Evaluative attitudes toward violence are related to violent behaviour and are important predictors of violence. The temporal stability of evaluative attitudes toward violence has not yet been examined. Attitudes have been shown to have a h…
View article: Behavioral Markers for Deficits in Speed of Processing in Cerebrovascular Disease
Behavioral Markers for Deficits in Speed of Processing in Cerebrovascular Disease Open
Objective To assess overlap and uniqueness of established behavioral markers of speed of processing for different aspects of visual information within a cerebrovascular disease cohort, and to examine the link between these speed of process…
View article: The Ontario Neurodegenerative Disease Research Initiative
The Ontario Neurodegenerative Disease Research Initiative Open
Objective In individuals over the age of 65, concomitant neurodegenerative pathologies contribute to cognitive and/or motor decline and can be aggravated by cerebrovascular disease, but our understanding of how these pathologies synergize …
View article: Determining Safe Participation in Aerobic Exercise Early After Stroke Through a Graded Submaximal Exercise Test
Determining Safe Participation in Aerobic Exercise Early After Stroke Through a Graded Submaximal Exercise Test Open
Objective The benefits of aerobic exercise early after stroke are well known, but concerns about cardiovascular risk are a barrier to clinical implementation. Symptom-limited exercise testing with electrocardiography (ECG) is recommended b…
View article: The utility of multivariate outlier detection techniques for data quality evaluation in large studies: an application within the ONDRI project
The utility of multivariate outlier detection techniques for data quality evaluation in large studies: an application within the ONDRI project Open
Manual QC procedures are insufficient for large studies as many errors remain undetected. In these data, the MCD outperforms the RPCA for identifying errors, and both are more successful than univariate approaches. Therefore, data-driven m…
View article: Examining physiotherapist use of structured aerobic exercise testing to decrease barriers to aerobic exercise
Examining physiotherapist use of structured aerobic exercise testing to decrease barriers to aerobic exercise Open
Objective: To determine the frequency of physiotherapist-administered aerobic exercise testing/training, the proportion of physiotherapists who administer this testing/training, and the barriers that currently exist across different practi…
View article: Examining physiotherapist use of structured aerobic exercise testing to decrease barriers to aerobic exercise
Examining physiotherapist use of structured aerobic exercise testing to decrease barriers to aerobic exercise Open
Objective: To determine the frequency of physiotherapist-administered aerobic exercise testing/training, the proportion of physiotherapists who administer this testing/training, and the barriers that currently exist across different practi…