Julia Kaiser
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View article: Selective Targeting of a Defined Subpopulation of Corticospinal Neurons Using a Novel Klhl14-Cre Mouse Line Enables Molecular and Anatomical Investigations through Development into Maturity
Selective Targeting of a Defined Subpopulation of Corticospinal Neurons Using a Novel Klhl14-Cre Mouse Line Enables Molecular and Anatomical Investigations through Development into Maturity Open
The corticospinal tract (CST) facilitates skilled, precise movements, which necessitates that subcerebral projection neurons (SCPNs) establish segmentally specific connectivity with brainstem and spinal circuits. Developmental molecular de…
View article: Developmental molecular signatures define de novo cortico-brainstem circuit for skilled forelimb movement
Developmental molecular signatures define de novo cortico-brainstem circuit for skilled forelimb movement Open
View article: Selective Targeting of a Defined Subpopulation of Corticospinal Neurons using a Novel Klhl14-Cre Mouse Line Enables Molecular and Anatomical Investigations through Development into Maturity
Selective Targeting of a Defined Subpopulation of Corticospinal Neurons using a Novel Klhl14-Cre Mouse Line Enables Molecular and Anatomical Investigations through Development into Maturity Open
The corticospinal tract (CST) facilitates skilled, precise movements, which necessitates that subcerebral projection neurons (SCPN) establish segmentally specific connectivity with brainstem and spinal circuits. Developmental molecular del…
View article: STARQ: Domain-Invariant Brainstem Nuclei Segmentation and Signal Quantification
STARQ: Domain-Invariant Brainstem Nuclei Segmentation and Signal Quantification Open
A bstract Brainstem nuclei are hard to distinguish due to very few distinctive features which makes detecting them with high accuracy extremely difficult. We introduce StARQ that builds on SeBRe, a deep learning-based framework to segment …
View article: Deep learning-based behavioral profiling of rodent stroke recovery
Deep learning-based behavioral profiling of rodent stroke recovery Open
View article: Molecular specification of cortico-brainstem versus corticospinal projection neurons in development
Molecular specification of cortico-brainstem versus corticospinal projection neurons in development Open
Skilled motor control requires precise connections between subcerebral projection neurons (SCPN) in the cerebral cortex and their appropriate subcerebral targets in the brainstem or spinal cord. The brainstem is an important motor control …
View article: Revisiting Long-Distance Axon Growth Ability in the Developing Spinal Cord using a Novel Lesion Paradigm
Revisiting Long-Distance Axon Growth Ability in the Developing Spinal Cord using a Novel Lesion Paradigm Open
Established experimental lesions in the developing central nervous system (CNS) disrupt microenvironments critical for long-distance axon growth and guidance. Therefore, the precise developmental time at which the CNS ceases its capacity t…
View article: ZuMult: Neue Zugangswege zu Korpora gesprochener Sprache
ZuMult: Neue Zugangswege zu Korpora gesprochener Sprache Open
ZuMult ("Zugänge zu multimodalen Korpora gesprochener Sprache -Vernetzung und zielgruppenspezifische Ausdifferenzierung") ist ein Kooperationsprojekt zwischen drei Partnern mit großen Sammlungen mündlicher Korpora der deutschen Sprache: de…
View article: Deep learning based behavioral profiling of rodent stroke recovery
Deep learning based behavioral profiling of rodent stroke recovery Open
Stroke research heavily relies on rodent behavior when assessing underlying disease mechanisms and treatment efficacy. Although functional motor recovery is considered the primary targeted outcome, tests in rodents are still poorly reprodu…
View article: Rule Talk: Instructing Proper Play With Impersonal Deontic Statements
Rule Talk: Instructing Proper Play With Impersonal Deontic Statements Open
The present paper explores how rules are enforced and talked about in everyday life. Drawing on a corpus of board game recordings across European languages, we identify a sequential and praxeological context for rule talk. After a game rul…
View article: Acyl-Ghrelin Influences Pancreatic β-Cell Function by Interference with KATP Channels
Acyl-Ghrelin Influences Pancreatic β-Cell Function by Interference with KATP Channels Open
The aim for this study was to elucidate how the hypothalamic hunger-inducing hormone acyl-ghrelin (AG), which is also produced in the pancreas, affects β-cell function, with particular attention to the role of ATP-sensitive K+ (KATP) chann…
View article: Possible New Strategies for the Treatment of Congenital Hyperinsulinism
Possible New Strategies for the Treatment of Congenital Hyperinsulinism Open
NN414 seems to provide a good alternative to the currently used KATP channel opener diazoxide. Targeting KCa3.1 channels by channel openers or L-type Ca2+ channels by DXM or simvastatin might be valuable ap…
View article: Formulating other minds in social interaction: Accountability and courses of action
Formulating other minds in social interaction: Accountability and courses of action Open
We examine moments in social interaction in which a person formulates what another thinks or believes. Such formulations of belief constitute a practice with specifiable contexts and consequences. Belief formulations treat aspects of the o…
View article: TGFβ1 Induces Axonal Outgrowth via ALK5/PKA/SMURF1-Mediated Degradation of RhoA and Stabilization of PAR6
TGFβ1 Induces Axonal Outgrowth via ALK5/PKA/SMURF1-Mediated Degradation of RhoA and Stabilization of PAR6 Open
Transforming growth factor (TGF)β1 has repeatedly been associated with axonal regeneration and recovery after injury to the CNS. We found TGFβ1 upregulated in the stroke-denervated mouse spinal cord after ischemic injury to the motor corte…
View article: Nogo-A Beyond the RhoA/ROCK Pathway – Novel Components of Intracellular Nogo-A Signaling Cascades
Nogo-A Beyond the RhoA/ROCK Pathway – Novel Components of Intracellular Nogo-A Signaling Cascades Open
Nogo-A is a well-characterized myelin-associated membrane protein that restricts fibre growth and the regenerative capacity of the adult central nervous system after injury. To date Nogo-A post-receptor signalling pathway research focused …
View article: Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2
Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2 Open
View article: Targeting Therapeutic Antibodies to the CNS: a Comparative Study of Intrathecal, Intravenous, and Subcutaneous Anti-Nogo A Antibody Treatment after Stroke in Rats
Targeting Therapeutic Antibodies to the CNS: a Comparative Study of Intrathecal, Intravenous, and Subcutaneous Anti-Nogo A Antibody Treatment after Stroke in Rats Open
View article: Approved LXR agonists exert unspecific effects on pancreatic β-cell function
Approved LXR agonists exert unspecific effects on pancreatic β-cell function Open
Novel agonists of the nuclear liver-X-receptor (LXR) are designed to treat metabolic disorders or cancer. The rationale to develop these new drugs is based on promising results with established LXR agonist like T0901317 and GW3965. LXRα an…
View article: Interactions between Atorvastatin and the Farnesoid X Receptor Impair Insulinotropic Effects of Bile Acids and Modulate Diabetogenic Risk
Interactions between Atorvastatin and the Farnesoid X Receptor Impair Insulinotropic Effects of Bile Acids and Modulate Diabetogenic Risk Open
View article: Maskierung von Audio- und Videoaufnahmen
Maskierung von Audio- und Videoaufnahmen Open
Die folgenden Ausführungen zur Maskierung basieren auf den Erfahrungen bei der Aufbereitung der Daten des Forschungs- und Lehrkorpus Gesprochenes Deutsch (FOLK) für die Veröffentlichung in der Datenbank für Gesprochenes Deutsch (DGD). Sie …
View article: The Spinal Transcriptome after Cortical Stroke: In Search of Molecular Factors Regulating Spontaneous Recovery in the Spinal Cord
The Spinal Transcriptome after Cortical Stroke: In Search of Molecular Factors Regulating Spontaneous Recovery in the Spinal Cord Open
In response to cortical stroke and unilateral corticospinal tract degeneration, compensatory sprouting of spared corticospinal fibers is associated with recovery of skilled movement in rodents. To date, little is known about the molecular …
View article: Common miRNA Patterns of Alzheimer’s Disease and Parkinson’s Disease and Their Putative Impact on Commensal Gut Microbiota
Common miRNA Patterns of Alzheimer’s Disease and Parkinson’s Disease and Their Putative Impact on Commensal Gut Microbiota Open
With the rise of Next-Generation-Sequencing (NGS) methods, Micro-RNAs (miRNAs) have achieved an important position in the research landscape and have been found to present valuable diagnostic tools in various diseases such as multiple scle…
View article: DGD – die Datenbank für Gesprochenes Deutsch
DGD – die Datenbank für Gesprochenes Deutsch Open
View article: Normalisieren mit OrthoNormal. Konventionen und Bedienungshinweise für die orthografische Normalisierung von FOLKER-Transkripten
Normalisieren mit OrthoNormal. Konventionen und Bedienungshinweise für die orthografische Normalisierung von FOLKER-Transkripten Open
View article: TGR5 Activation Promotes Stimulus-Secretion Coupling of Pancreatic β-Cells via a PKA-Dependent Pathway
TGR5 Activation Promotes Stimulus-Secretion Coupling of Pancreatic β-Cells via a PKA-Dependent Pathway Open
The Takeda-G-protein-receptor-5 (TGR5) mediates physiological actions of bile acids. Since it was shown that TGR5 is expressed in pancreatic tissue, a direct TGR5 activation in β-cells is currently postulated and discussed. The current stu…
View article: Early reduced behavioral activity induced by large strokes affects the efficiency of enriched environment in rats
Early reduced behavioral activity induced by large strokes affects the efficiency of enriched environment in rats Open
The majority of stroke patients develop post-stroke fatigue, a symptom which impairs motivation and diminishes the success of rehabilitative interventions. We show that large cortical strokes acutely reduce activity levels in rats for 1–2 …
View article: The Spinal Transcriptome after Cortical Stroke and its Impact on Sprouting and “Side-Switch” of Contralesional Corticospinal Fibers
The Spinal Transcriptome after Cortical Stroke and its Impact on Sprouting and “Side-Switch” of Contralesional Corticospinal Fibers Open
View article: Nogo-A antibodies enhance axonal repair and remyelination in neuro-inflammatory and demyelinating pathology
Nogo-A antibodies enhance axonal repair and remyelination in neuro-inflammatory and demyelinating pathology Open
View article: Insights into the Dual Role of Inflammation after Spinal Cord Injury
Insights into the Dual Role of Inflammation after Spinal Cord Injury Open
Injuries to the CNS lead to severe and often irreversible deficits in sensorimotor and autonomous function. In spinal cord injury (SCI), mechanical damage results in the death of local neurons and glia at the lesion site within minutes to …
View article: Reformulierungsindikatoren im gesprochenen Deutsch: Die Benutzung der Ressourcen DGD und FOLK für gesprächsanalytische Zwecke
Reformulierungsindikatoren im gesprochenen Deutsch: Die Benutzung der Ressourcen DGD und FOLK für gesprächsanalytische Zwecke Open
Dieser Beitrag stellt nach einer kurzen allgemeinen Einfuhrung die Datenbank fur Gesprochenes Deutsch (DGD) und das Forschungs- und Lehrkorpus Gesprochenes Deutsch (FOLK) als Instrumente speziell fur gesprachsanalytisches Arbeiten vor. Anh…