Julia G. Levy
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View article: Activation of stress-activated kinases and inhibition of PI 3-K/PKB and p70S6K mitogenic signaling pathway by photodynamic therapy in murine keratinocytes
Activation of stress-activated kinases and inhibition of PI 3-K/PKB and p70S6K mitogenic signaling pathway by photodynamic therapy in murine keratinocytes Open
Photodynamic therapy (PDT) is a new anti-cancer modality. It involves the use of photosensitizer molecules and a specific wavelength of visible light. The process of PDT generates singlet oxygen and other reactive oxygen intermediates (ROI…
View article: IL-10 Contributes to the Inhibition of Contact Hypersensitivity in Mice Treated with Photodynamic Therapy
IL-10 Contributes to the Inhibition of Contact Hypersensitivity in Mice Treated with Photodynamic Therapy Open
We have explored the effect of photodynamic therapy (PDT) with verteporfin on the induction and expression of contact hypersensitivity (CHS) to 2,4-dinitrofluorobenzene (DNFB) in normal mice and IL-10-deficient mice. Our results indicate t…
View article: Photodynamic Alteration of the Surface Receptor Expression Pattern of Murine Splenic Dendritic Cells
Photodynamic Alteration of the Surface Receptor Expression Pattern of Murine Splenic Dendritic Cells Open
The photosensitizer benzoporphyrin‐derivative monoacid ring A (BPD‐MA, verteporfin), in combination with visible light irradiation, a clinical procedure termed photodynamic therapy (PDT), has immunomodulatory activity in various mouse mode…
View article: Bcl-2 overexpression blocks caspase activation and downstream apoptotic events instigated by photodynamic therapy
Bcl-2 overexpression blocks caspase activation and downstream apoptotic events instigated by photodynamic therapy Open
Treatment with the photosensitizer benzoporphyrin derivative monoacid ring A (BPD-MA, verteporfin) followed by irradiation with visible light induces apoptosis in human acute myelogenous leukaemia HL-60 cells. Photoactivation of BPD-MA ind…
View article: Uptake of Verteporfin® by articular tissues following systemic and intra-articular administration
Uptake of Verteporfin® by articular tissues following systemic and intra-articular administration Open
Photodynamic therapy (PDT) using the photosensitizer BPD-Verteporfin (liposomal benzoporphyrin derivative-monoacid ring A) has been shown in previous studies to be effective in the amelioration of inflammatory arthritis in both the MRL-lpr…
View article: Use Of Green Porphyrinsto Treat Neovasculature In The Eyes
Use Of Green Porphyrinsto Treat Neovasculature In The Eyes Open
Photodynamic therapy of conditions of the eye characterized by unwanted neovasculature, such as age-related macular degeneration, is effective using green porphyrins as photoactive agents, preferably as liposomal compositions.
View article: Overexpression of Bcl‐X<sub>L</sub> prevents caspase‐3‐mediated activation of DNA fragmentation factor (DFF) produced by treatment with the photochemotherapeutic agent BPD‐MA
Overexpression of Bcl‐X<sub>L</sub> prevents caspase‐3‐mediated activation of DNA fragmentation factor (DFF) produced by treatment with the photochemotherapeutic agent BPD‐MA Open
Photodynamic therapy (PDT) is a clinically effective cancer treatment. For human promyelocytic leukemia HL‐60 cells, cleavage of pro‐caspase‐3 (CPP32/Yama/apopain) into its proteolytically active subunits rapidly follows the photodynamic t…
View article: Stimulation of Stress-activated Protein Kinase and p38 HOG1 Kinase in Murine Keratinocytes following Photodynamic Therapy with Benzoporphyrin Derivative
Stimulation of Stress-activated Protein Kinase and p38 HOG1 Kinase in Murine Keratinocytes following Photodynamic Therapy with Benzoporphyrin Derivative Open
The activation state of the members of the mitogen-activated protein kinase family following photodynamic therapy (PDT) with benzoporphyrin derivative monoacid ring A was investigated using a naturally transformed murine keratinocyte cell …
View article: Evaluation of a model for post-partum arthritis and the role of oestrogen in prevention of MRL-<i>lpr</i>associated rheumatic conditions
Evaluation of a model for post-partum arthritis and the role of oestrogen in prevention of MRL-<i>lpr</i>associated rheumatic conditions Open
SUMMARY Sixty-eight percent of female MRL-lpr- mice developed a post-partum exacerbation of their mild spontaneous arthritis within 30 days of parturition- The flare became evident between 5 and 15 days after delivery. Histologically it wa…
View article: Dye-mediated photolysis is capable of eliminating drug-resistant (MDR+) tumor cells
Dye-mediated photolysis is capable of eliminating drug-resistant (MDR+) tumor cells Open
We evaluated the potential role of photoradiation therapy with a benzoporphyrin derivative, monoacid ring A (BPD-MA), and dihematoporphyrin ether (DHE), for the ex vivo purging of residual tumor cells from autologous bone marrow (BM) graft…
View article: Dye-mediated photolysis is capable of eliminating drug-resistant (MDR+) tumor cells
Dye-mediated photolysis is capable of eliminating drug-resistant (MDR+) tumor cells Open
We evaluated the potential role of photoradiation therapy with a benzoporphyrin derivative, monoacid ring A (BPD-MA), and dihematoporphyrin ether (DHE), for the ex vivo purging of residual tumor cells from autologous bone marrow (BM) graft…
View article: Suppressor cell-inducing factor: a new lymphokine secreted by a natural suppressor cell line with natural cytotoxic activity. I. Purification to apparent homogeneity and initial characterization of suppressor cell-inducing factor.
Suppressor cell-inducing factor: a new lymphokine secreted by a natural suppressor cell line with natural cytotoxic activity. I. Purification to apparent homogeneity and initial characterization of suppressor cell-inducing factor. Open
The lymphokine suppressor cell-inducing factor (SIF), obtained from 15 liters of serum-free culture supernatants of the natural suppressor cell line, M1-A5, has been purified to apparent homogeneity by a combination of gel filtration, ion …
View article: Isolation of an antigen-specific T suppressor factor that suppresses the in vivo response of DBA/2 mice to ferredoxin.
Isolation of an antigen-specific T suppressor factor that suppresses the in vivo response of DBA/2 mice to ferredoxin. Open
A T cell hybridoma (Fd11) has been produced from B10.D2 mice that secretes a putative antigen-specific T suppressor factor (TsF). The TsF is isolable from culture supernatants of Fd11 by affinity purification over columns containing either…
View article: Isolation of a T-cell clone that reacts with both antigen and anti-idiotype: evidence for anti-idiotype as internal image for antigen at the T-cell level.
Isolation of a T-cell clone that reacts with both antigen and anti-idiotype: evidence for anti-idiotype as internal image for antigen at the T-cell level. Open
T-cell lines were derived from ferredoxin nonresponder B10.D2 mice that share an idiotype expressed by a monoclonal antibody (Fd-B2) with specificity for one of the two major antigenic determinants (the C determinant) of the antigen. The T…
View article: Evidence for the presence of idiotype-bearing regulatory T cells in which idiotype expression does not show linkage to either IgH alleles or the MHC.
Evidence for the presence of idiotype-bearing regulatory T cells in which idiotype expression does not show linkage to either IgH alleles or the MHC. Open
An anti-idiotypic antiserum was raised in rabbits to a monoclonal antibody with specificity for one of the two antigenic determinants on the ferredoxin (Fd) molecule. The monoclonal antibody (Fd-B2) was derived from fusion of spleen cells …
View article: Identification of an idiotypic marker of a major regulatory T cell of the immune response in B10.BR mice to ferredoxin. The relationship of idiotypic regulation to conventional hapten-carrier effects.
Identification of an idiotypic marker of a major regulatory T cell of the immune response in B10.BR mice to ferredoxin. The relationship of idiotypic regulation to conventional hapten-carrier effects. Open
An anti-idiotypic antiserum was raised in rabbits to a monoclonal antibody (Fd-1) with specificity for one (the N epitope) of the two antigenic epitopes found on the ferredoxin (Fd) molecule. The anti-idiotypic antiserum (anti-Fd-1) was us…
View article: Detection of a tumor-associated antigen on the surface of human myelogenous leukemia cells.
Detection of a tumor-associated antigen on the surface of human myelogenous leukemia cells. Open
Membrane extracts of human acute myelogenous leukemia cells were passed over immunoadsorbent columns containing antibodies directed to equivalent preparations of pooled normal peripheral blood leukocytes. This material, when compared to eq…
View article: Further Characterization of Thymic Suppressor Cells and a Factor That Suppress the Generation of Cells Cytotoxic for a Syngeneic Tumor in DBA/2 Mice
Further Characterization of Thymic Suppressor Cells and a Factor That Suppress the Generation of Cells Cytotoxic for a Syngeneic Tumor in DBA/2 Mice Open
Antigen-specific suppressor cells and suppressive extracts obtained from the thymuses of DBA/2 mice bearing small syngeneic P815 mastocytomas were compared for their immunogenetic properties and requirements. The assay for specific suppres…
View article: Two Distinct Populations of Suppressor Cells in the Spleens of Mice Bearing Methylcholanthrene-Induced Tumors
Two Distinct Populations of Suppressor Cells in the Spleens of Mice Bearing Methylcholanthrene-Induced Tumors Open
The suppressor cells found in the spleens of mice bearing advanced tumors could be divided into two different populations by centrifugation on Hypaque-Ficoll of specific gravity 1.08. The cells in the light fraction suppressed the in vitro…
View article: Identity of a T-lymphocyte inhibitor with mouse immunoglobulin in the serum of tumour-bearing mice.
Identity of a T-lymphocyte inhibitor with mouse immunoglobulin in the serum of tumour-bearing mice. Open
A component of the serum of tumour-bearing mice has been shown to be inhibitory to the immunological function of normal mouse T cells. This factor fractionates with monomeric immunoglobulin upon gel filtration. Studies were carried out uti…
View article: Characterization of Suppressor Cells in Mice Bearing Syngeneic Mastocytoma
Characterization of Suppressor Cells in Mice Bearing Syngeneic Mastocytoma Open
Suppressor cells from syngeneic P815 mastocytoma-bearing DBA/2 mice that inhibit in vitro generation of specific anti-tumor cytotoxicity were characterized. Suppressive activity was almost completely eliminated by treating suppressive sple…
View article: The immune response to oxidized ferredoxin. II. Cross reactivity of cells and antisera to modified ferredoxins and the nature of the cells responding in vitro.
The immune response to oxidized ferredoxin. II. Cross reactivity of cells and antisera to modified ferredoxins and the nature of the cells responding in vitro. Open
The cross reactivity of sera from rabbits sensitized to performic acid oxidized ferredoxin (O-Fd) and of spleen cells from mice sensitized to O-Fd was analysed using several chemically modified forms of ferredoxin in the complement fixatio…
View article: The immune response to oxidized ferredoxin. I. Specificity of the response to the amino terminal determinant.
The immune response to oxidized ferredoxin. I. Specificity of the response to the amino terminal determinant. Open
Several synthetic peptide analogues of the amino terminal antigenic determinant (ala-tyr-lysile-ala-asp-ser) of oxidized ferredoxin (O-Fd) were tested for their ability to inhibit the complement fixation reaction between O-Fd and homologou…
View article: Cellular co-operation by mouse lymphocytes to chemically defined antigens.
Cellular co-operation by mouse lymphocytes to chemically defined antigens. Open
When populations of mouse spleen cells were treated with a highly radioactive 125I-labelled haptenic conjugate (125I-labelled PDG-N) and subsequently injected into X-irradiated, immunized (N-10-C) syngeneic BALB/c mice, it was found that a…