Julia Linke
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View article: Cross-Cultural Consortium on Irritability (C3I): An International Network for Research on Cultural Similarities and Differences in Irritability
Cross-Cultural Consortium on Irritability (C3I): An International Network for Research on Cultural Similarities and Differences in Irritability Open
View article: Network analysis suggests working memory as a key target for facilitating subjective well-being
Network analysis suggests working memory as a key target for facilitating subjective well-being Open
Using a Bayesian network approach, our findings point toward working memory as a potential key mechanism of well-being. Future work is needed to replicate these findings and determine the robustness of the identified network.
View article: Gamified Attention Bias Modification Training to Augment Cognitive–Behavioral Therapy for Youth Anxiety Disorders: A Randomized Controlled Trial
Gamified Attention Bias Modification Training to Augment Cognitive–Behavioral Therapy for Youth Anxiety Disorders: A Randomized Controlled Trial Open
View article: Behavior in motivational conflicts is determined by magnitude of potential outcomes and relates to anxiety levels
Behavior in motivational conflicts is determined by magnitude of potential outcomes and relates to anxiety levels Open
Human behavior often involves resolving conflicts between motivations to pursue rewards and to avoid harm. Maladaptive resolution of such approach-avoidance conflicts is a hallmark of various psychopathologies, notably anxiety disorders. T…
View article: Structure-function coupling in network connectivity and associations with negative affectivity in a group of transdiagnostic adolescents
Structure-function coupling in network connectivity and associations with negative affectivity in a group of transdiagnostic adolescents Open
View article: Associations Between Neighborhood Resources and Youths’ Response to Reward Omission in a Task Modeling Negatively Biased Environments
Associations Between Neighborhood Resources and Youths’ Response to Reward Omission in a Task Modeling Negatively Biased Environments Open
One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science. One or more of the authors of this paper self-identifies as a member of one or more h…
View article: Multivariate Assessment of Inhibitory Control in Youth: Links With Psychopathology and Brain Function
Multivariate Assessment of Inhibitory Control in Youth: Links With Psychopathology and Brain Function Open
Inhibitory control is central to many theories of cognitive and brain development, and impairments in inhibitory control are posited to underlie developmental psychopathology. In this study, we tested the possibility of shared versus uniqu…
View article: Modeling Shared and Specific Variances of Irritability, Inattention, and Hyperactivity Yields Novel Insights Into White Matter Perturbations
Modeling Shared and Specific Variances of Irritability, Inattention, and Hyperactivity Yields Novel Insights Into White Matter Perturbations Open
View article: Normalization of Fronto-Parietal Activation by Cognitive-Behavioral Therapy in Unmedicated Pediatric Patients With Anxiety Disorders
Normalization of Fronto-Parietal Activation by Cognitive-Behavioral Therapy in Unmedicated Pediatric Patients With Anxiety Disorders Open
Activation in fronto-parietal networks may normalize after CBT in unmedicated pediatric anxiety patients. Limbic regions may be less amenable to acute CBT effects. Findings from the at-risk sample suggest that treatment-related changes may…
View article: Irritability, Negative Life Events, and the Course of Anxiety and Depressive Symptoms in a Clinical Sample of Youth: A Longitudinal Study
Irritability, Negative Life Events, and the Course of Anxiety and Depressive Symptoms in a Clinical Sample of Youth: A Longitudinal Study Open
View article: A meta-analysis on the uncinate fasciculus in depression
A meta-analysis on the uncinate fasciculus in depression Open
Aberrant microstructure of the uncinate fasciculus (UNC), a white matter (WM) tract implicated in emotion regulation, has been hypothesized as a neurobiological mechanism of depression. However, studies testing this hypothesis have yielded…
View article: Robust caregiver-youth discrepancies in irritability ratings on the affective reactivity index: An investigation of its origins
Robust caregiver-youth discrepancies in irritability ratings on the affective reactivity index: An investigation of its origins Open
View article: Persistent Frustration-Induced Reconfigurations of Brain Networks Predict Individual Differences in Irritability
Persistent Frustration-Induced Reconfigurations of Brain Networks Predict Individual Differences in Irritability Open
These pilot results suggest the importance of the postfrustration recovery period in the pathophysiology of irritability. Eglob in 3 specific posttask modules, involved in emotion processing, reward processing, or motor function…
View article: Informant-discrepancy in the Affective Reactivity Index Reflects the Multifaceted Nature of Childhood and Adolescent Irritability
Informant-discrepancy in the Affective Reactivity Index Reflects the Multifaceted Nature of Childhood and Adolescent Irritability Open
Objective: The Affective Reactivity Index (ARI) is widely used to assess young people’s irritability symptoms, but youth and caregivers often diverge in their assessments. Such informant discrepancy might stem from poor reliability. Howeve…
View article: Changes in Internalizing Symptoms During the COVID-19 Pandemic in a Transdiagnostic Sample of Youth: Exploring Mediators and Predictors
Changes in Internalizing Symptoms During the COVID-19 Pandemic in a Transdiagnostic Sample of Youth: Exploring Mediators and Predictors Open
The COVID-19 pandemic is a chronically stressful event, particularly for youth. Here, we examine (i) changes in mood and anxiety symtpoms, (ii) pandemic-related stress as a mediator of change in symptoms, and (ii) threat processing biases …
View article: Context-dependent amygdala–prefrontal connectivity during the dot-probe task varies by irritability and attention bias to angry faces
Context-dependent amygdala–prefrontal connectivity during the dot-probe task varies by irritability and attention bias to angry faces Open
View article: Threat imminence reveals links among unfolding of anticipatory physiological response, cortical-subcortical intrinsic functional connectivity, and anxiety
Threat imminence reveals links among unfolding of anticipatory physiological response, cortical-subcortical intrinsic functional connectivity, and anxiety Open
View article: Persistent frustration-induced reconfigurations of brain networks predict individual differences in irritability
Persistent frustration-induced reconfigurations of brain networks predict individual differences in irritability Open
Background Frustration, the response to blocked goal attainment, is a universal affective experience, but how the brain embodies frustration is not known. Understanding brain network dynamics during frustration may provide insight into ped…
View article: The uncinate fasciculus in individuals with and at risk for bipolar disorder: A meta-analysis
The uncinate fasciculus in individuals with and at risk for bipolar disorder: A meta-analysis Open
Our findings support aberrant UF microstructure, potentially related to alterations in myelination, as a mechanism, but not as an endophenotype of BD. However, given the limited power in the REL subsample, the latter finding must be consid…
View article: Aberrant Subnetwork and Hub Dysconnectivity in Adult Bipolar Disorder: A Multicenter Graph Theory Analysis
Aberrant Subnetwork and Hub Dysconnectivity in Adult Bipolar Disorder: A Multicenter Graph Theory Analysis Open
Neuroimaging evidence implicates structural network-level abnormalities in bipolar disorder (BD); however, there remain conflicting results in the current literature hampered by sample size limitations and clinical heterogeneity. Here, we …
View article: Threat imminence reveals links among unfolding of anticipatory physiological response, cortical-subcortical intrinsic functional connectivity, and anxiety
Threat imminence reveals links among unfolding of anticipatory physiological response, cortical-subcortical intrinsic functional connectivity, and anxiety Open
Excessive expression of threat-anticipatory defensive responses is central in anxiety. Animal research indicates that anticipatory responses are dynamically organized by threat imminence and rely on conserved circuitry. Insight from transl…
View article: The role of the uncinate fasciculus in the risk-architecture of bipolar disorders: A meta-analysis
The role of the uncinate fasciculus in the risk-architecture of bipolar disorders: A meta-analysis Open
Background Bipolar disorder (BD) is a severe mental disorder, characterized by prominent mood swings and emotion regulation (ER) deficits. The uncinate fasciculus (UF), a white matter tract connecting the amygdala and the ventral prefronta…
View article: Shared and Anxiety-Specific Pediatric Psychopathology Dimensions Manifest Distributed Neural Correlates
Shared and Anxiety-Specific Pediatric Psychopathology Dimensions Manifest Distributed Neural Correlates Open
Findings revealed two replicable types of clinical variates, one related to multiple symptom dimensions and a second relatively specific to anxiety. Both types involved a multitude of broadly distributed, weak brain connections as opposed …
View article: White Matter Microstructure in Individuals With and At Risk for Bipolar Disorder: Evidence for an Endophenotype From a Voxel-Based Meta-analysis
White Matter Microstructure in Individuals With and At Risk for Bipolar Disorder: Evidence for an Endophenotype From a Voxel-Based Meta-analysis Open
View article: White matter microstructure in youth with and at risk for bipolar disorder
White matter microstructure in youth with and at risk for bipolar disorder Open
Objectives Bipolar disorder (BD) and familial risk for BD have been associated with aberrant white matter (WM) microstructure in the corpus callosum and fronto‐limbic pathways. These abnormalities might constitute trait or state marker and…
View article: Combining fMRI during resting state and an attention bias task in children
Combining fMRI during resting state and an attention bias task in children Open
View article: Correction: Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals
Correction: Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals
Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals Open
View article: Cerebellar parcellation in schizophrenia and bipolar disorder
Cerebellar parcellation in schizophrenia and bipolar disorder Open
Objective The cerebellum is involved in cognitive processing and emotion control. Cerebellar alterations could explain symptoms of schizophrenia spectrum disorder (SZ) and bipolar disorder (BD). In addition, literature suggests that lithiu…
View article: Efficacy and mechanisms underlying a gamified attention bias modification training in anxious youth: protocol for a randomized controlled trial
Efficacy and mechanisms underlying a gamified attention bias modification training in anxious youth: protocol for a randomized controlled trial Open