Xiaoqiu Liu
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View article: Continuous versus intermittent beta-lactam antibiotic infusions in critically ill patients: The UK cohort of the BLING III trial
Continuous versus intermittent beta-lactam antibiotic infusions in critically ill patients: The UK cohort of the BLING III trial Open
Background: There are theoretical reasons why beta-lactam antibiotics may be more effective in treating severe infections if administered by continuous infusion, rather than short intermittent infusions. The Beta-Lactam Infusion Group (BLI…
View article: Study On The Adhesive Properties Between Silicone Rubber And Peek
Study On The Adhesive Properties Between Silicone Rubber And Peek Open
Aim or purpose: To evaluate the effects of different surface treatment methods on the bonding strength between polyether-ether-ketone (PEEK) and medical silicone rubber. Materials and methods: Forty sanded PEEK specimens were randomly divi…
View article: Ph-Responsive Mesoporous Silica-Reinforced Composite Resin With Remineralization Capability
Ph-Responsive Mesoporous Silica-Reinforced Composite Resin With Remineralization Capability Open
Aim or purpose: The enhancement of mechanical properties in composite resins and dentin remineralization can effectively prolong the service life of dental restorations. This study designed a pH-responsive dental composite resin, of which …
View article: A finite element analysis of cracked mandibular first molar with crown
A finite element analysis of cracked mandibular first molar with crown Open
Background: Tooth fracture has gradually become a leading cause of tooth loss, following caries and periodontal disease, but the protection of cracked teeth is still a challenge. This study aimed to assess the stress distribution in cracke…
View article: Epidemiological features of tuberculosis infection in a high-altitude population: a population-based, cross-sectional survey in Tibet, China
Epidemiological features of tuberculosis infection in a high-altitude population: a population-based, cross-sectional survey in Tibet, China Open
Background Targeted strategies for marginalized populations, including high-altitude communities, are crucial for TB elimination. This study assessed TB infection (TBI) prevalence across altitudinal gradients and evaluated altitude-depende…
View article: Citrullination of AKT2 Catalyzed by PAD1 Facilitates the Maintenance of Stemness Characteristics of Ovarian Cancer Stem‐Like Cells in Ovarian Cancer
Citrullination of AKT2 Catalyzed by PAD1 Facilitates the Maintenance of Stemness Characteristics of Ovarian Cancer Stem‐Like Cells in Ovarian Cancer Open
The presence of ovarian cancer stem‐like cells (OCSLCs) is a crucial driving force for malignant progression, metastasis, and tumor recurrence of ovarian cancer (OC). However, the mechanisms underlying activation and maintenance of OCSLC s…
View article: Statistical Analysis Plan for RECITAL: a non-inferiority randomised control trial evaluating a virtual fracture clinic compared with in-person care for people with simple fractures
Statistical Analysis Plan for RECITAL: a non-inferiority randomised control trial evaluating a virtual fracture clinic compared with in-person care for people with simple fractures Open
2 Abstract The Fracture Clinic Trial (RECITAL) is a prospective two-arm, parallel-group randomised controlled trial, using a non-inferiority design with nested economic and process evaluations. It aims to determine whether virtual care pro…
View article: pH-Responsive mesoporous silica nanoparticle-reinforced composite resin with remineralization capability
pH-Responsive mesoporous silica nanoparticle-reinforced composite resin with remineralization capability Open
A composite formulation containing 45 wt% A-MSNs and 15 wt% Pchi/ACP (Group A) significantly enhanced mechanical strength. The 15 wt% Pchi/ACP formulation (Group D) demonstrated the greatest remineralization effect. Group B, combining A-MS…
View article: Effects of surface treatments on the adhesion strengths between polyether ether ketone and both composite resins and poly(methyl methacrylate)
Effects of surface treatments on the adhesion strengths between polyether ether ketone and both composite resins and poly(methyl methacrylate) Open
NaBH4 introduced chemical bonds to the PEEK surface, while concentrated-H2SO4-induced sulfonation enhanced the micromechanical interlocking between the PEEK and both the composite resins and PMMA. These combined physicochemical modificatio…
View article: Analysis of epidemiological characteristics and psychopsychological factors of arrhythmia in the elderly
Analysis of epidemiological characteristics and psychopsychological factors of arrhythmia in the elderly Open
BACKGROUND Irregular heart rhythms are a primary manifestation of cardiovascular disease, considerably contributing to global morbidity and mortality rates. Moreover, patients with cardiac arrhythmias often experience a higher prevalence o…
View article: Design and Development of Infiltration Resins: From Base Monomer Structure to Resin Properties
Design and Development of Infiltration Resins: From Base Monomer Structure to Resin Properties Open
The resin infiltration concept is one of the most widely used minimally invasive restorative techniques in restorative dentistry with the most outstanding therapeutic effect, and it is also one of the key research directions in restorative…
View article: Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis
Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis Open
Importance Whether β-lactam antibiotics administered by continuous compared with intermittent infusion reduces the risk of death in patients with sepsis is uncertain. Objective To evaluate whether continuous vs intermittent infusion of a β…
View article: Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock
Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock Open
Importance There is uncertainty about whether prolonged infusions of β-lactam antibiotics improve clinically important outcomes in critically ill adults with sepsis or septic shock. Objective To determine whether prolonged β-lactam antibio…
View article: Isolation, characterization and functional analysis of a bacteriophage targeting Culex pipiens pallens resistance-associated Aeromonas hydrophila
Isolation, characterization and functional analysis of a bacteriophage targeting Culex pipiens pallens resistance-associated Aeromonas hydrophila Open
Background Culex pipiens pallens is a well-known mosquito vector for several diseases. Deltamethrin, a commonly used pyrethroid insecticide, has been frequently applied to manage adult Cx. pipiens pallens . However, mosquitoes can develop …
View article: P122 Digital spatial profiling reveals the predictive characteristics in patients with immune checkpoint inhibitor-induced colitis
P122 Digital spatial profiling reveals the predictive characteristics in patients with immune checkpoint inhibitor-induced colitis Open
Background The increasing use of immune checkpoint inhibitors (ICIs) against cancers is inevitably accompanied with immune-related adverse events (irAEs), and irAE colitis is one of the common types. The overactivation of CD8+ T cells play…
View article: Inhibiting MEK1 R189 citrullination enhances the chemosensitivity of docetaxel to multiple tumour cells
Inhibiting MEK1 R189 citrullination enhances the chemosensitivity of docetaxel to multiple tumour cells Open
Drug resistance is still a big challenge for cancer patients. We previously demonstrated that inhibiting peptidylarginine deiminase 2 (PADI2) enzyme activity with Cl-amine increases the efficacy of docetaxel (Doc) on tamoxifen-resistant br…
View article: [Prediction of 1p/19q codeletion status in diffuse lower-grade glioma using multimodal MRI radiomics].
[Prediction of 1p/19q codeletion status in diffuse lower-grade glioma using multimodal MRI radiomics]. Open
Multiparametric MRI radiomics models show good performance for noninvasive prediction of 1p/19q codeletion status in patients with in diffuse lower-grade glioma.
View article: [Clinical and gene mutation characteristics of patients with hereditary ellipsocytosis: nine cases report and literature review].
[Clinical and gene mutation characteristics of patients with hereditary ellipsocytosis: nine cases report and literature review]. Open
Objective: To report gene mutations in nine patients with hereditary elliptocytosis (HE) and analyze the characteristics of pathogenic gene mutations in HE. Methods: The clinical and gene mutations of nine patients clinically diagnosed wit…
View article: Effects of an Amino Acid-Based Formula Supplemented with Two Human Milk Oligosaccharides on Growth, Tolerability, Safety, and Gut Microbiome in Infants with Cow’s Milk Protein Allergy
Effects of an Amino Acid-Based Formula Supplemented with Two Human Milk Oligosaccharides on Growth, Tolerability, Safety, and Gut Microbiome in Infants with Cow’s Milk Protein Allergy Open
This open-label, non-randomized, multicenter trial (Registration: NCT 03661736) aimed to assess if an amino acid-based formula (AAF) supplemented with two human milk oligosaccharides (HMO) supports normal growth and is well tolerated in in…
View article: The incorporation of phosphorylated chitosan/amorphous calcium phosphate nanocomplex into an experimental composite resin
The incorporation of phosphorylated chitosan/amorphous calcium phosphate nanocomplex into an experimental composite resin Open
This study evaluated the effect of incorporating phosphorylated chitosan/amorphous calcium phosphate nanocomplex (Pchi/ACP) into an experimental light-cure composite resin on mechanical-chemical properties and human dentin remineralization…
View article: Secondhand smoke presence in outdoor areas in 12 European countries
Secondhand smoke presence in outdoor areas in 12 European countries Open
SHS presence is high in most outdoor areas in Europe, especially in countries with higher smoking prevalence and lower tobacco control performance. To address outdoor SHS exposure, our findings require considering smoking bans along with o…
View article: Use and Awareness of Heated Tobacco Products in Europe
Use and Awareness of Heated Tobacco Products in Europe Open
Background: Heated tobacco products (HTP) are new forms of tobacco consumption with limited information available on their use among the general population. Our objective was to analyze the prevalence and associations of use of HTP across …