Julia Morales
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View article: Osteogenesis imperfecta and the family: A qualitative analysis of the experiences of family and caregivers.
Osteogenesis imperfecta and the family: A qualitative analysis of the experiences of family and caregivers. Open
Findings have implications for child and caregiver well-being and health care professionals during diagnosis and emphasize the need for social support for families affected by OI. Future research should engage a more diverse (in terms of e…
View article: Hormone-regulated dynamics of mRNA distribution on ribosomes in Sertoli cells
Hormone-regulated dynamics of mRNA distribution on ribosomes in Sertoli cells Open
The effects of hormone stimulation on the cell translational profile remain poorly understood. Here, using polysome profiling combined to RNA sequencing, we analyzed the translational response to follicle-stimulating hormone (FSH) of prima…
View article: Postembryonic Maintenance of Nephron Progenitor Cells with Low Translational Activity in the Chondrichthyan Scyliorhinus canicula
Postembryonic Maintenance of Nephron Progenitor Cells with Low Translational Activity in the Chondrichthyan Scyliorhinus canicula Open
Key Points Unlike mammals, chondrichthyan species exhibit postembryonic nephrogenesis, where new nephrons are continuously added in the kidney. Nephron progenitor cells in catsharks display slow cycling property, akin to other somatic stem…
View article: Evaluating parental perception and confidence managing obesity-related behaviors among children with severe early-onset obesity
Evaluating parental perception and confidence managing obesity-related behaviors among children with severe early-onset obesity Open
Background Severe early-onset obesity, defined as a BMI exceeding 120% of the 95th percentile before age 5, often involves hyperphagia, characterized by insatiable hunger and shortened satiety duration. Treatment generally requires caregiv…
View article: Blood Biomarker and Physical Activity Correlations in Persons with Parkinson’s Disease
Blood Biomarker and Physical Activity Correlations in Persons with Parkinson’s Disease Open
Parkinson’s disease (PD) is a debilitating disease that reduces an individual’s quality of life (QOL). PD has a complex pathophysiology, but inflammation is a major contributor. Inflammation is a biological process that removes harmful sti…
View article: Role of transcription and translation during the early development of the brown alga<i>Ectocarpus</i>
Role of transcription and translation during the early development of the brown alga<i>Ectocarpus</i> Open
Background and aims Parthenogenesis, the embryonal development of an unfused gamete, is a widespread trait within the brown algae (Phaeophyceae). We hypothesized that the parthenogenetic development of male gametes of the model brown alga …
View article: Analysis of the P. lividus sea urchin genome highlights contrasting trends of genomic and regulatory evolution in deuterostomes
Analysis of the P. lividus sea urchin genome highlights contrasting trends of genomic and regulatory evolution in deuterostomes Open
View article: The Roscoff Biological Station in the era of cellular and molecular biology: Focus on the 50 last years of research on marine animals
The Roscoff Biological Station in the era of cellular and molecular biology: Focus on the 50 last years of research on marine animals Open
In the context of the 150th anniversary of the biological station of Roscoff, we describe here how cellular and molecular biology using marine metazoans has been developed at the station during the last 50 years. The discipline was first i…
View article: eIF4B mRNA Translation Contributes to Cleavage Dynamics in Early Sea Urchin Embryos
eIF4B mRNA Translation Contributes to Cleavage Dynamics in Early Sea Urchin Embryos Open
During the first steps of sea urchin development, fertilization elicits a marked increase in protein synthesis essential for subsequent cell divisions. While the translation of mitotic cyclin mRNAs is crucial, we hypothesized that addition…
View article: The genomic repertoire for cell cycle control and DNA metabolism in S. purpuratus
The genomic repertoire for cell cycle control and DNA metabolism in S. purpuratus Open
A search of the Strongylocentrotus purpuratus genome for genes associated with cell cycle control and DNA metabolism shows that the known repertoire of these genes is conserved in the sea urchin, although with fewer family members represen…
View article: Echinoderms : Focus on the Sea Urchin Model in Cellular and Developmental Biology
Echinoderms : Focus on the Sea Urchin Model in Cellular and Developmental Biology Open
International audience
View article: mTOR Signaling at the Crossroad between Metazoan Regeneration and Human Diseases
mTOR Signaling at the Crossroad between Metazoan Regeneration and Human Diseases Open
A major challenge in medical research resides in controlling the molecular processes of tissue regeneration, as organ and structure damage are central to several human diseases. A survey of the literature reveals that mTOR (mechanistic/mam…
View article: A Peak of H3T3 Phosphorylation Occurs in Synchrony with Mitosis in Sea Urchin Early Embryos
A Peak of H3T3 Phosphorylation Occurs in Synchrony with Mitosis in Sea Urchin Early Embryos Open
The sea urchin embryo provides a valuable system to analyse the molecular mechanisms orchestrating cell cycle progression and mitosis in a developmental context. However, although it is known that the regulation of histone activity by post…
View article: Translational Control of Canonical and Non-Canonical Translation Initiation Factors at the Sea Urchin Egg to Embryo Transition
Translational Control of Canonical and Non-Canonical Translation Initiation Factors at the Sea Urchin Egg to Embryo Transition Open
Sea urchin early development is a powerful model to study translational regulation under physiological conditions. Fertilization triggers an activation of the translation machinery responsible for the increase of protein synthesis necessar…
View article: Caracterización del olor de nuevas variedades de mandarina sin semillas obtenidas en el IVIA
Caracterización del olor de nuevas variedades de mandarina sin semillas obtenidas en el IVIA Open
El estudio de las similitudes y deferencias en el olor de nuevas variedades sin semilla obtenidas en el IVIA mostró que las variedades triploides obtenidas por hibridación sexual son mucho más aromáticas que las variedades obtenidas por mu…
View article: Cambios sensoriales durante la conservación frigorífica de naranjas sanguinas
Cambios sensoriales durante la conservación frigorífica de naranjas sanguinas Open
La evaluación de los cambios sensoriales durante la conservación frigorífica de naranjas sanguinas reveló que la fruta mantiene una buena calidad externa e interna durante 30 días. El aspecto externo tras 45 resultó limitante para su comer…
View article: In vivo analysis of protein translation activity in sea urchin eggs and embryos
In vivo analysis of protein translation activity in sea urchin eggs and embryos Open
View article: Translatome analysis at the egg-to-embryo transition in sea urchin
Translatome analysis at the egg-to-embryo transition in sea urchin Open
Early embryogenesis relies on the translational regulation of maternally stored mRNAs. In sea urchin, fertilization triggers a dramatic rise in translation activity, necessary for the onset of cell division. Here, the full spectrum of the …
View article: Toward Multiscale Modeling of Molecular and Biochemical Events Occurring at Fertilization Time in Sea Urchins
Toward Multiscale Modeling of Molecular and Biochemical Events Occurring at Fertilization Time in Sea Urchins Open
View article: Indicadores para evaluar la competencia digital docente en la formación inicial en el contexto Chileno – Uruguayo / Indicators to Assess Digital Competence of Teachers in Initial Training in the Chile - Uruguay Contex
Indicadores para evaluar la competencia digital docente en la formación inicial en el contexto Chileno – Uruguayo / Indicators to Assess Digital Competence of Teachers in Initial Training in the Chile - Uruguay Contex Open
El docente es un factor relevante en la inserción de las Tecnologías de la Información y Comunicación (TIC) en la educación. Es necesario que los docentes desarrollen la competencia digital docente (CDD), para usar las TIC en las mejorar l…
View article: MAPK/ERK activity is required for the successful progression of mitosis in sea urchin embryos
MAPK/ERK activity is required for the successful progression of mitosis in sea urchin embryos Open
Using sea urchin embryos, we demonstrate that the MEK/MAPK/ERK cascade is essential for the proper progression of the cell cycle. Activation of a limited fraction of MAPK/ERK is required between S-phase and M-phase. Neither DNA replication…
View article: Model of the delayed translation of cyclin B maternal mRNA after sea urchin fertilization
Model of the delayed translation of cyclin B maternal mRNA after sea urchin fertilization Open
SUMMARY Sea urchin eggs exhibit a cap‐dependent increase in protein synthesis within minutes after fertilization. This rise in protein synthesis occurs at a constant rate for a great number of proteins translated from the different availab…
View article: Analysis of translation using polysome profiling
Analysis of translation using polysome profiling Open
During the past decade, there has been growing interest in the role of translational regulation of gene expression in many organisms. Polysome profiling has been developed to infer the translational status of a specific mRNA species or to …
View article: Cyclin B Translation Depends on mTOR Activity after Fertilization in Sea Urchin Embryos
Cyclin B Translation Depends on mTOR Activity after Fertilization in Sea Urchin Embryos Open
The cyclin B/CDK1 complex is a key regulator of mitotic entry. Using PP242, a specific ATP-competitive inhibitor of mTOR kinase, we provide evidence that the mTOR signalling pathway controls cyclin B mRNA translation following fertilizatio…