Julia Paczkowska
YOU?
Author Swipe
View article: 21 | PROGNOSTIC VALUE OF CIRCULATING TUMOR DNA IN PATIENTS WITH ADVANCED STAGE CLASSIC HODGKIN LYMPHOMA TREATED ON SWOG S1826
21 | PROGNOSTIC VALUE OF CIRCULATING TUMOR DNA IN PATIENTS WITH ADVANCED STAGE CLASSIC HODGKIN LYMPHOMA TREATED ON SWOG S1826 Open
View article: Cancer-specific innate and adaptive immune rewiring drives resistance to PD-1 blockade in classic Hodgkin lymphoma
Cancer-specific innate and adaptive immune rewiring drives resistance to PD-1 blockade in classic Hodgkin lymphoma Open
Hodgkin Reed-Sternberg (HRS) cells of classic Hodgkin lymphoma (cHL), like many solid tumors, elicit ineffective immune responses. However, patients with cHL are highly responsive to PD-1 blockade, which largely depends on HRS cell-specifi…
View article: Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment
Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment Open
Classic Hodgkin Lymphoma (cHL) is a tumor composed of rare malignant Hodgkin and Reed-Sternberg (HRS) cells nested within a T-cell rich inflammatory immune infiltrate. cHL is associated with Epstein-Barr Virus (EBV) in 25% of cases. The sp…
View article: Deregulated hsa‐miR‐23a‐3p and hsa‐mir‐148a‐3p influence key processes in classic Hodgkin lymphoma (cHL) pathogenesis
Deregulated hsa‐miR‐23a‐3p and hsa‐mir‐148a‐3p influence key processes in classic Hodgkin lymphoma (cHL) pathogenesis Open
Introduction: We previously performed global miRNA expression profiling of cHL vs. non-Hodgkin lymphoma (NHL) cell lines and sorted germinal centre B-cells (GCB). In the group of 79 deregulated miRNAs (p < 0.05) we became particularly inte…
View article: T028: Single-cell RNA sequencing reveals the interplay between circulating CD4 T cells, B cells and cancer-associated monocytes in classic Hodgkin lymphoma treated with PD-1 blockade
T028: Single-cell RNA sequencing reveals the interplay between circulating CD4 T cells, B cells and cancer-associated monocytes in classic Hodgkin lymphoma treated with PD-1 blockade Open
Classic Hodgkin lymphoma (cHL) is a largely MHC class I-negative tumor with recurrent 9p24.1/ PD-L1/ PD-L2 copy gains and the highest reported response rates to PD-1 blockade. In cHL, the efficacy of PD-1 blockade is closely associated wit…
View article: Loss of the MAF Transcription Factor in Laryngeal Squamous Cell Carcinoma
Loss of the MAF Transcription Factor in Laryngeal Squamous Cell Carcinoma Open
MAF is a transcription factor that may act either as a tumor suppressor or as an oncogene, depending on cell type. We have shown previously that the overexpressed miR-1290 influences MAF protein levels in LSCC (laryngeal squamous cell carc…
View article: Deregulated miRNAs Contribute to Silencing of B-Cell Specific Transcription Factors and Activation of NF-κB in Classical Hodgkin Lymphoma
Deregulated miRNAs Contribute to Silencing of B-Cell Specific Transcription Factors and Activation of NF-κB in Classical Hodgkin Lymphoma Open
A hallmark of classical Hodgkin lymphoma (cHL) is the attenuation of B-cell transcription factors leading to global transcriptional reprogramming. The role of miRNAs (microRNAs) involved in this process is poorly studied. Therefore, we per…
View article: Laryngeal squamous cell carcinoma cell lines show high tolerance for siRNA-mediated CDK1 knockdown.
Laryngeal squamous cell carcinoma cell lines show high tolerance for siRNA-mediated CDK1 knockdown. Open
Alterations of the cell cycle checkpoints lead to uncontrolled cell growth and result in tumorigenesis. One of the genes essential for cell proliferation and cell cycle regulation is CDK1. This makes it a potential target in cancer …
View article: The Tumor Suppressive mir-148a Is Epigenetically Inactivated in Classical Hodgkin Lymphoma
The Tumor Suppressive mir-148a Is Epigenetically Inactivated in Classical Hodgkin Lymphoma Open
DNA methylation was shown previously to be a crucial mechanism responsible for transcriptional deregulation in the pathogenesis of classical Hodgkin lymphoma (cHL). To identify epigenetically inactivated miRNAs in cHL, we have analyzed the…
View article: Discrimination between human populations using a small number of differentially methylated CpG sites: A preliminary study using lymphoblastoid cell lines and peripheral blood samples of European and Chinese origin.
Discrimination between human populations using a small number of differentially methylated CpG sites: A preliminary study using lymphoblastoid cell lines and peripheral blood samples of European and Chinese origin. Open
Background Epigenetics is one of the factors shaping natural variability observed among human populations. A small proportion of heritable inter-population differences are observed in the context of both the genome-wide methylation level a…
View article: Discrimination between human populations using a small number of differentially methylated CpG sites: A preliminary study using lymphoblastoid cell lines and peripheral blood samples of Caucasian and Chinese origin.
Discrimination between human populations using a small number of differentially methylated CpG sites: A preliminary study using lymphoblastoid cell lines and peripheral blood samples of Caucasian and Chinese origin. Open
Background Epigenetics is one of the factors shaping natural variability observed among human populations. A small proportion of heritable inter-population differences are observed in the context of both the genome-wide methylation level a…
View article: Expression of <scp>ELF</scp>1, a lymphoid <scp>ETS</scp> domain‐containing transcription factor, is recurrently lost in classical Hodgkin lymphoma
Expression of <span>ELF</span>1, a lymphoid <span>ETS</span> domain‐containing transcription factor, is recurrently lost in classical Hodgkin lymphoma Open
Summary Loss of B cell‐specific transcription factors (TFs) and the resulting loss of B‐cell phenotype of Hodgkin and Reed‐Sternberg (HRS) cells is a hallmark of classical Hodgkin lymphoma (cHL). Here we have analysed two members of ETS do…
View article: PO-380 Epigenetically regulated MAF is a new potential tumour suppressor gene in LSCC
PO-380 Epigenetically regulated MAF is a new potential tumour suppressor gene in LSCC Open
Introduction Laryngeal cancer (LSCC) is one of the most common tumours among head and neck squamous cell carcinomas. Recently, analysis of the meaning of epigenetic alterations in LSCC development has gained momentum. In this field we hav…
View article: PO-379 Novel tumour specific miRNA expressed in classical hodgkin lymphoma cell lines
PO-379 Novel tumour specific miRNA expressed in classical hodgkin lymphoma cell lines Open
Introduction MiRNAs are short non coding RNAs involved in post-transcriptional regulation of gene expression that can acquire oncogenic properties in consequence of overexpression or mutations. Tumour genomes undergo global demethylation …
View article: Combined deletion and DNA methylation result in silencing of FAM107A gene in laryngeal tumors
Combined deletion and DNA methylation result in silencing of FAM107A gene in laryngeal tumors Open
View article: Global miRNA Expression Profiling Identifies miR-1290 as Novel Potential oncomiR in Laryngeal Carcinoma
Global miRNA Expression Profiling Identifies miR-1290 as Novel Potential oncomiR in Laryngeal Carcinoma Open
Taken together, we propose miR-1290 as the new oncomiR involved in LSCC pathogenesis. Additionally, we suggest that the oncogenic potential of miR-1290 might be expressed by the involvement in downregulation of its target genes MAF and ITP…