Julia Roider
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View article: Effective and safe use of immune checkpoint inhibitors for non‐small cell lung cancer in people living with <scp>HIV</scp>
Effective and safe use of immune checkpoint inhibitors for non‐small cell lung cancer in people living with <span>HIV</span> Open
Objectives With the near normalization of life expectancy in people living with HIV through antiretroviral therapy, the management of age‐related comorbidities has become increasingly important. Non‐AIDS‐defining cancers now contribute sig…
View article: Detectable SARS-CoV-2 specific immune responses in recovered unvaccinated individuals 250 days post wild type infection
Detectable SARS-CoV-2 specific immune responses in recovered unvaccinated individuals 250 days post wild type infection Open
Memory T cells play an important role in mediating long-lasting adaptive immune responses to viral infections, such as SARS-CoV-2. In the context of the latter, much of our current knowledge stems from studies in vaccinated individuals or …
View article: Early treatment and PD1 inhibition enhance HIV-specific functionality of follicular CD8+ T cells
Early treatment and PD1 inhibition enhance HIV-specific functionality of follicular CD8+ T cells Open
People living with HIV treated during acute infection are the group for whom achieving functional cure appears most viable. Follicular CD8+ T cells could contribute to HIV reservoir clearance by accessing B cell follicles through CXCR5 exp…
View article: HLA-F expression on CD4 T cells in HIV-1 is linked to the presence of viremia and modulated by KIR3DS1
HLA-F expression on CD4 T cells in HIV-1 is linked to the presence of viremia and modulated by KIR3DS1 Open
KIR3DS1 is an activating natural killer (NK) cell receptor gene– present in 10-40% of humans– and is associated with extended AIDS-free survival. Although its ligand HLA-F has been identified, the underlying protective mechanism in HIV-1 i…
View article: Author Correction: Sustained aviremia despite anti-retroviral therapy non-adherence in male children after in utero HIV transmission
Author Correction: Sustained aviremia despite anti-retroviral therapy non-adherence in male children after in utero HIV transmission Open
View article: Predicting work ability impairment in post COVID-19 patients: a machine learning model based on clinical parameters
Predicting work ability impairment in post COVID-19 patients: a machine learning model based on clinical parameters Open
The Post COVID-19 condition (PCC) is a complex disease affecting health and everyday functioning. This is well reflected by a patient’s inability to work (ITW). In this study, we aimed to investigate factors associated with ITW (1) and to …
View article: Predicting work ability impairment in Post COVID-19 patients: a machine learning model based on clinical parameters
Predicting work ability impairment in Post COVID-19 patients: a machine learning model based on clinical parameters Open
The Post COVID-19 condition (PCC) is a complex disease affecting health and everyday functioning. This is well reflected by a patient’s inability to work (ITW). In this study, we aimed to investigate factors associated with ITW and to desi…
View article: Sustained aviremia despite anti-retroviral therapy non-adherence in male children after in utero HIV transmission
Sustained aviremia despite anti-retroviral therapy non-adherence in male children after in utero HIV transmission Open
View article: Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cells
Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cells Open
View article: Persistent immune abnormalities discriminate post-COVID syndrome from convalescence
Persistent immune abnormalities discriminate post-COVID syndrome from convalescence Open
Background Innate lymphoid cells (ILCs) are key organizers of tissue immune responses and regulate tissue development, repair, and pathology. Persistent clinical sequelae beyond 12 weeks following acute COVID-19 disease, named post-COVID s…
View article: The DoDo experience: an alternative antiretroviral 2-drug regimen of doravirine and dolutegravir
The DoDo experience: an alternative antiretroviral 2-drug regimen of doravirine and dolutegravir Open
Background Currently available antiretroviral 2-drug regimen (2DR) fixed dose combinations may not be suitable for specific situations including the presence of resistance associated mutations (RAM) or drug − drug interactions (DDI). The d…
View article: Persistent immune abnormalities discriminate post-COVID syndrome from convalescence
Persistent immune abnormalities discriminate post-COVID syndrome from convalescence Open
Innate lymphoid cells (ILCs) are key organizers of tissue immune responses and regulate tissue development, repair, and pathology. Persistent clinical sequelae beyond 12 weeks following acute COVID-19 disease, named post-COVID syndrome (PC…
View article: The DoDo Experience: An Alternative Antiretroviral 2-Drug Regimen of Doravirine and Dolutegravir
The DoDo Experience: An Alternative Antiretroviral 2-Drug Regimen of Doravirine and Dolutegravir Open
Background: Currently available antiretroviral 2-drug regimen (2DR) fixed dose combinations may not be suitable for specific situations including the presence of resistance associated mutations (RAM) or drug-drug interactions. Data on the …
View article: Rapid point of care testing for four bacterial sexually transmitted infections using the portable isothermal loop-mediated nucleic acid amplification eazyplex platform
Rapid point of care testing for four bacterial sexually transmitted infections using the portable isothermal loop-mediated nucleic acid amplification eazyplex platform Open
View article: Slow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype
Slow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype Open
HIV nonprogression despite persistent viremia is rare among adults who are naive to antiretroviral therapy (ART) but relatively common among ART-naive children. Previous studies indicate that ART-naive pediatric slow progressors (PSPs) ado…
View article: Autoantibody-Enhanced, CD32-Driven Trogocytosis Creates Functional Plasticity of Immune Cells and is Hijacked by HIV-1 to Infect Resting CD4 T Cells
Autoantibody-Enhanced, CD32-Driven Trogocytosis Creates Functional Plasticity of Immune Cells and is Hijacked by HIV-1 to Infect Resting CD4 T Cells Open
View article: Rapid Point of Care Testing for Sexually Transmitted Infections Using a Portable Isothermal Loop Mediated Nucleic Acid Amplification Platform
Rapid Point of Care Testing for Sexually Transmitted Infections Using a Portable Isothermal Loop Mediated Nucleic Acid Amplification Platform Open
Purpose To analyze sensitivity and specificity of the rapid point-of-care (POC) eazyplex STD complete testing platform for sexually transmitted infections (STI) among men who have sex with men (MSM). Methods 272 anal, urethral, and pharyng…
View article: Affenpocken: Werde ich den ersten Fall erkennen?
Affenpocken: Werde ich den ersten Fall erkennen? Open
View article: Affenpocken in der Hausarztpraxis - werde ich den ersten Fall erkennen?
Affenpocken in der Hausarztpraxis - werde ich den ersten Fall erkennen? Open
View article: Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C
Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C Open
NK cells play a pivotal role in viral immunity, utilizing a large array of activating and inhibitory receptors to identify and eliminate virus-infected cells. Killer-cell immunoglobulin-like receptors (KIRs) represent a highly polymorphic …
View article: Broad T Cell Targeting of Structural Proteins After SARS-CoV-2 Infection: High Throughput Assessment of T Cell Reactivity Using an Automated Interferon Gamma Release Assay
Broad T Cell Targeting of Structural Proteins After SARS-CoV-2 Infection: High Throughput Assessment of T Cell Reactivity Using an Automated Interferon Gamma Release Assay Open
Background Adaptive immune responses to structural proteins of the virion play a crucial role in protection against coronavirus disease 2019 (COVID-19). We therefore studied T cell responses against multiple SARS-CoV-2 structural proteins …
View article: Early Initiation of Antiretroviral Therapy Following In Utero HIV Infection Is Associated With Low Viral Reservoirs but Other Factors Determine Viral Rebound
Early Initiation of Antiretroviral Therapy Following In Utero HIV Infection Is Associated With Low Viral Reservoirs but Other Factors Determine Viral Rebound Open
Background Early HIV diagnosis allows combination antiretroviral therapy (cART) initiation in the first days of life following in utero (IU) infection. The impact of early cART initiation on infant viral reservoir size in the setting of hi…
View article: Abstracts of the 10th German/Austrian AIDS Conference
Abstracts of the 10th German/Austrian AIDS Conference Open
Introduction: A prophylactic HIV vaccine would ideally induce protective immunity during childhood, prior to sexual debut.Children develop potent broadly neutralising antibody (bnAb) responses faster and at higher frequencies than adults, …
View article: Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection
Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection Open
To protect future generations against HIV, a vaccine will need to induce immunity by the time of sexual debut and hence requires immunization during childhood. Current strategies for a prophylactic HIV vaccine include the induction of a br…
View article: Corrigendum: Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life
Corrigendum: Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life Open
[This corrects the article DOI: 10.3389/fimmu.2020.01587.].
View article: Corrigendum: Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life (Frontiers in Immunology, (2020), 11, (1587), 10.3389/fimmu.2020.01587)
Corrigendum: Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life (Frontiers in Immunology, (2020), 11, (1587), 10.3389/fimmu.2020.01587) Open
View article: Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life
Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life Open
Human cytomegalovirus (CMV) is a highly prevalent herpesvirus, particularly in sub-Saharan Africa, where it is endemic from infancy. The T cell response against CMV is important in keeping the virus in check, with CD8 T cells playing a maj…
View article: Unbiased Profiling Reveals Compartmentalization of Unconventional T-Cells Within the Intestinal Mucosa Irrespective of HIV Infection
Unbiased Profiling Reveals Compartmentalization of Unconventional T-Cells Within the Intestinal Mucosa Irrespective of HIV Infection Open
The intestinal mucosa is enriched for unconventional T-cells, including mucosal associated invariant T-cells (MAIT), invariant natural killer T-cells (iNKT) and γδ T-cells. These cells are activated by bacterial metabolites, lipid antigens…
View article: Integration of microarray data and literature mining identifies a sex bias in DPP4+CD4+ T cells in HIV-1 infection
Integration of microarray data and literature mining identifies a sex bias in DPP4+CD4+ T cells in HIV-1 infection Open
HIV-1 infection exhibits a significant sex bias. This study aimed at identifying and examining lymphocyte associated sex differences in HIV-1 pathogenesis using a data-driven approach. To select targets for investigating sex differences in…
View article: Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy
Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy Open