Julia Roosz
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View article: Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines
Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines Open
Pancreatic ductal adenocarcinoma (PDAC) remains a major clinical challenge due to late detection and limited treatment responsiveness. To better evaluate complex immunotherapies in a human‐relevant setting, we developed an integrated organ…
View article: Antineoplastic Activity of a Novel Trispecific Single-Chain Antibody Targeting the hERG1/β1 Integrin Complex and TRAIL Receptors
Antineoplastic Activity of a Novel Trispecific Single-Chain Antibody Targeting the hERG1/β1 Integrin Complex and TRAIL Receptors Open
Targeted therapies and immunotherapies have largely improved cancer treatment in the last years. One of the most promising approaches is the induction of tumor apoptosis by TRAIL through its binding to apoptosis-inducing receptors DR4 and …
View article: Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells
Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells Open
Physiologically relevant human models that recapitulate the challenges of solid tumors and the tumor microenvironment (TME) are highly desired in the chimeric antigen receptor (CAR)-T cell field. We developed a breast cancer-on-chip model …
View article: Autologous Human Immunocompetent White Adipose Tissue‐on‐Chip
Autologous Human Immunocompetent White Adipose Tissue‐on‐Chip Open
Obesity and associated diseases, such as diabetes, have reached epidemic proportions globally. In this era of “diabesity”, white adipose tissue (WAT) has become a target of high interest for therapeutic strategies. To gain insights into me…
View article: Autologous human immunocompetent white adipose tissue-on-chip
Autologous human immunocompetent white adipose tissue-on-chip Open
Obesity and associated diseases, such as diabetes, have reached epidemic proportions globally. In the era of ‘diabesity’ and due to its central role for metabolic and endocrine processes, adipose tissue (specifically white adipose tissue; …
View article: Human stem cell-based retina-on-chip as new translational model for validation of AAV retinal gene therapy vectors
Human stem cell-based retina-on-chip as new translational model for validation of AAV retinal gene therapy vectors Open
Summary Gene therapies using adeno-associated viruses (AAVs) are amongst the most promising strategies to treat or even cure hereditary and acquired retinal diseases. However, the development of new efficient AAV vectors is slow and costly…