Julia Shanks
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View article: Cardiac Sympathetic Nerve Activity Is Not Elevated in Ovine Hypertensive HFpEF
Cardiac Sympathetic Nerve Activity Is Not Elevated in Ovine Hypertensive HFpEF Open
BACKGROUND: The sympathetic nervous system is a crucial mediator of cardiovascular variables during exercise. However, its role in heart failure with preserved ejection fraction (HFpEF), where exercise intolerance is a cardinal feature, is…
View article: Reverse remodelling of the mitochondria and cytoskeleton after respiratory heart rate variability pacing of the failing sheep heart
Reverse remodelling of the mitochondria and cytoskeleton after respiratory heart rate variability pacing of the failing sheep heart Open
We have previously demonstrated that pacing the failing sheep heart with respiratory heart rate variability (RespHRV), a natural variability in the heart rate that is linked to respiration on a breath-by-breath basis, improves cardiac outp…
View article: Cardiac Vagal Nerve Activity During Exercise: New insights and future directions
Cardiac Vagal Nerve Activity During Exercise: New insights and future directions Open
A new paradigm is emerging in which cardiac vagal nerve activity is maintained and increases during exercise. This paradigm challenges decades of studies that have quoted a withdrawal of cardiac vagal activity during exercise. Here, we out…
View article: Characterization of a novel ovine model of hypertensive heart failure with preserved ejection fraction
Characterization of a novel ovine model of hypertensive heart failure with preserved ejection fraction Open
We show that older, female sheep with chronic 2-kidney, 1-clip hypertension have similar cardiac and noncardiac exercise hemodynamic abnormalities as patients with HFpEF. This clinically relevant, translatable, and novel large animal model…
View article: Sympathetic transduction of cardiac sympathetic nerve activity in healthy, conscious sheep
Sympathetic transduction of cardiac sympathetic nerve activity in healthy, conscious sheep Open
Sympathetic transduction is the study of how impulses of sympathetic nerve activity (SNA) affect end‐organ function. Recently, the transduction of resting bursts of muscle SNA (MSNA) has been investigated and shown to have a role in the ma…
View article: Meet the First Authors
Meet the First Authors Open
In 2013 he co-founded InSyBio, a bioinformatics company with expertise in biomarker discovery.He is also the author of two patent applications and is the recipient of numerous
View article: Neural control of coronary artery blood flow by non‐adrenergic and non‐cholinergic mechanisms
Neural control of coronary artery blood flow by non‐adrenergic and non‐cholinergic mechanisms Open
Blood flow through the coronary vasculature is essential to maintain myocardial function. As the metabolic demand of the heart increases, so does blood flow through the coronary arteries in a dynamic and adaptive manner. Several mechanisms…
View article: Reverse re-modelling chronic heart failure by reinstating heart rate variability
Reverse re-modelling chronic heart failure by reinstating heart rate variability Open
Heart rate variability (HRV) is a crucial indicator of cardiovascular health. Low HRV is correlated with disease severity and mortality in heart failure. Heart rate increases and decreases with each breath in normal physiology termed respi…
View article: Angiotensin II and the Cardiac Parasympathetic Nervous System in Hypertension
Angiotensin II and the Cardiac Parasympathetic Nervous System in Hypertension Open
The renin–angiotensin–aldosterone system (RAAS) impacts cardiovascular homeostasis via direct actions on peripheral blood vessels and via modulation of the autonomic nervous system. To date, research has primarily focused on the actions of…
View article: Regulation of Coronary Blood Flow by the Carotid Body Chemoreceptors in Ovine Heart Failure
Regulation of Coronary Blood Flow by the Carotid Body Chemoreceptors in Ovine Heart Failure Open
Carotid bodies (CBs) are peripheral chemoreceptors, which are primary sensors of systemic hypoxia and their activation produces respiratory, autonomic, and cardiovascular adjustments critical for body homeostasis. We have previously shown …
View article: TRPV1 (Transient Receptor Potential Vanilloid 1) Cardiac Spinal Afferents Contribute to Hypertension in Spontaneous Hypertensive Rat
TRPV1 (Transient Receptor Potential Vanilloid 1) Cardiac Spinal Afferents Contribute to Hypertension in Spontaneous Hypertensive Rat Open
Hypertension is associated with increased sympathetic activity. A component of this sympathoexcitation may be driven by increased signaling from sensory endings from the heart to the autonomic control areas in the brain. This pathway media…
View article: Sympatho-excitatory response to pulmonary chemosensitive spinal afferent activation in anesthetized, vagotomized rats
Sympatho-excitatory response to pulmonary chemosensitive spinal afferent activation in anesthetized, vagotomized rats Open
The sensory innervation of the lung is well known to be innervated by nerve fibers of both vagal and sympathetic origin. Although the vagal afferent innervation of the lung has been well characterized, less is known about physiological eff…
View article: Overexpression of Sarcoendoplasmic Reticulum Calcium ATPase 2a Promotes Cardiac Sympathetic Neurotransmission via Abnormal Endoplasmic Reticulum and Mitochondria Ca <sup>2+</sup> Regulation
Overexpression of Sarcoendoplasmic Reticulum Calcium ATPase 2a Promotes Cardiac Sympathetic Neurotransmission via Abnormal Endoplasmic Reticulum and Mitochondria Ca <sup>2+</sup> Regulation Open
Reduced cardiomyocyte excitation–contraction coupling and downregulation of the SERCA2a (sarcoendoplasmic reticulum calcium ATPase 2a) is associated with heart failure. This has led to viral transgene upregulation of SERCA2a in cardiomyocy…
View article: Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt+ Cells in Murine Heart
Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt+ Cells in Murine Heart Open
In the present study, channelrhodopsin 2 (ChR2) was specifically introduced into murine cells expressing the Phenylethanolamine n-methyltransferase (Pnmt ) gene, which encodes for the enzyme responsible for conversion of noradrenaline to a…
View article: C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function
C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function Open
C-type natriuretic peptide reduces cardiac sympathetic neurotransmission via a reduction in neuronal calcium signalling and NE release through the NPR-B receptor. Situations impairing CNP-NPR-B signalling lead to hypertension, tachycardia,…