Explanipedia

The development of a clinical prediction model for response to methotrexate, tofacitinib, and etanercept in patients with Psoriatic Arthritis Open

F. T. Perton, M.L.M. Bentvelzen, Sina Fadaei, Juliëtte Pouw, Julia Spierings , et al. · 2025

Background The aim of this study was to use clinical data to develop a prediction model for treatment response, comparing tofacitinib to methotrexate or etanercept in individual patients with Psoriatic Arthritis. Methods Data from the deve…

Impact of hand function impairment on daily life of patients with systemic sclerosis: a qualitative study Open

Mark Greveling, Stefano Rodolfi, Nora El Bardai, Christopher P. Denton, Voon H Ong , et al. · 2025

Objectives Many patients with systemic sclerosis (SSc) experience impaired hand function, yet the precise nature and impact of this impairment remains unclear. In this study, we explored the determinants of hand function impairment in SSc …

Deep hierarchical subtyping of multi-organ systemic sclerosis trajectories - a EUSTAR study Open

Cécile Trottet, Manuel Schürch, Ahmed E. Allam, L. Petelytska, I. Castellví , et al. · 2025

Definition of relapse criteria in patients with rapidly progressive systemic sclerosis treated with autologous haemopoietic stem cell transplantation Open

Nicoletta Del Papa, Myriam Labopin, Manuela Badoglio, Dominique Farge, Jörg Henes , et al. · 2025

Autologous haematopoietic stem cell transplantation for rheumatic diseases: best practice recommendations from the EBMT Practice Harmonization and Guidelines Committee Open

Tobias Alexander, Elisa Roldán, Nicoletta Del Papa, Dominique Farge, Jörg Henes , et al. · 2025

Immune-mediated rheumatologic and musculoskeletal diseases (RMDs) comprise a heterogeneous group of systemic conditions that affect the connective tissues of the musculoskeletal system and internal organs. Immune-mediated RMDs are driven b…

POS0305 TREATMENT RESPONSE PREDICTION IN PSORIATIC ARTHRITIS: ASSESSING THE ADDED VALUE OF MULTIMODAL IMAGING Open

Nağme Ö Renkli, S.C. Mastbergen, Julia Spierings, H.E. Vonkeman, S.C. Mooij , et al. · 2025

OP0003 CAN VASOACTIVE VASODILATING DRUGS INFLUENCE PROGRESSION AND PROGNOSIS OF SYSTEMIC SCLEROSIS-ASSOCIATED INTERSTITIAL LUNG DISEASE A EUSTAR COHORT STUDY Open

A.C. Sarbu, L. Petelytska, L. Tofani, G. Moroncini, A. Balbir-Gurman , et al. · 2025

POS0266 DEVELOPMENT OF AN ARTICULAR SCORE IN SYSTEMIC SCLEROSIS (ASSESS): IDENTIFICATION OF CORE INSTRUMENTS TO ASSESS DISEASE ACTIVITY Open

B. Burja, P.M. Welsing, Alain Lescoat, A. Eisenring, A.M. Hoffmann-Vold , et al. · 2025

POS0628 INDIVIDUAL PATIENT EXPRESSION PROFILES OF DISEASE ACTIVITY MARKERS MODIFY THE RELATIONSHIP OF DISEASE ACTIVITY WITH STRUCTURAL DISEASE PROGRESSION IN RA Open

C. Ripepi, P.M. Welsing, Jacob M. van Laar, Saskia Haitjema, Janneke Tekstra , et al. · 2025

ABS0367 PREDICTING CLINICAL RESPONSE IN PSORIATIC ARTHRITIS THROUGH INTEGRATIVE ANALYSIS OF PROTEOMICS AND TRANSCRIPTOMICS Open

M.L.M. Bentvelzen, Said el Bouhaddani, Julia Spierings, Harald E. Vonkeman, S.C. Mooij , et al. · 2025

P139 Impact of hand function impairment on daily life of patients with systemic sclerosis - a qualitative study Open

Mark Greveling, Stefano Rodolfi, Nora El Bardai, Christopher P. Denton, Sonja Dittmar , et al. · 2025

Background/Aims Systemic sclerosis (SSc) is a rare, autoimmune connective tissue disease characterized by widespread microvascular damage, skin thickening, and fibrotic changes in organs. Previous studies identified that many SSc patients …

Hand function impairment in Systemic sclerosis: Outcomes, Mechanisms and Experience (HANDSOME) – a longitudinal observational multicentre study protocol Open

Mark Greveling, Voon H Ong, Christopher P. Denton, Wouter Foppen, Amin Herman , et al. · 2025

Introduction The majority of all patients with systemic sclerosis (SSc) experience hand function impairment. The exact cause for this impairment is yet unknown. As impaired hand function hugely impacts daily functioning and quality of life…

Evaluation of Systemic Sclerosis Primary Heart Involvement and Chronic Heart Failure in the European Scleroderma Trials and Research Cohort Open

Andrea‐Hermina Györfi, Tim Filla, Amin Polzin, Koray Taşçılar, Maya H Buch , et al. · 2025

Background Systemic sclerosis (SSc) primary heart involvement (SSc‐pHI) is one of the leading causes of mortality in SSc. We aimed to evaluate risk factors for SSc‐pHI and its progression and the outcomes in the EUSTAR (European Scleroderm…

Management of disease progression after autologous hematopoietic stem cell transplantation in systemic sclerosis: Results from an international questionnaire-based study Open

Julia Spierings, Giulia Bandini, Yannick Allanore, Nicoletta Del Papa, Oliver Distler , et al. · 2025

Our study benchmarks the unique combined experiences of post-AHSCT management among SSc experts. We summarize preferences regarding definition of AHSCT failure and progression after response, as well as approach to diagnostic work-up and t…

Longitudinal association between nailfold capillaroscopy and incident interstitial lung disease: A EUSTAR database analysis Open

Arthiha Velauthapillai, Jeska K de Vries-Bouwstra, Jörg Henes, László Czirják, Lorenzo Dagna , et al. · 2025

Objectives: To evaluate (1) the association between nailfold capillaroscopy pattern and 5-year risk for incident interstitial lung disease and (2) the association between transition in nailfold capillaroscopy pattern and risk of incident i…

Quantitative 18F-FDG PET-CT can assess presence and extent of interstitial lung disease in early severe diffuse cutaneous systemic sclerosis Open

Bo Broens, Esther J. Nossent, Lilian J. Meijboom, Gerben J. C. Zwezerijnen, Julia Spierings , et al. · 2024

Background This study aimed to assess the quantitative uptake of 18 F-FDG PET-CT in the lungs of patients with early severe diffuse cutaneous systemic sclerosis (SSc) with and without interstitial lung disease (ILD), compared to controls. …

Dermal cellular senescence and EndMT in patients with systemic sclerosis undergoing cyclophosphamide or aHSCT treatment Open

Yu‐Hsiang Chiu, Marijke van Dijk, Roel Goldschmeding, J.M. van Laar, Jeska K de Vries-Bouwstra , et al. · 2024

Objectives Cellular senescence and endothelial-to-mesenchymal transition (EndMT) are profibrotic cellular processes involved in systemic sclerosis (SSc), but how they respond to treatment is largely unknown. Methods Skin biopsies from diff…

Cure as a treatment target in rheumatoid arthritis and systemic sclerosis—achievable aim or mission impossible? FOREUM stimulates new industry-academia collaboration Open

Kenneth F. Baker, Julia Spierings, Martín Brom, Timothy Radstake, Emma Smith , et al. · 2024

No abstract

Self-reported skin severity and quality of life in systemic sclerosis: multicentre validation of PASTUL Open

Julia Spierings, Paco M J Welsing, Seda Çolak, Helen Quah, Francesco Del Galdo , et al. · 2024

Objectives The aim of this study was to validate the Patient self-Assessment of Skin Thickness in Upper Limb (PASTUL) questionnaire in SSc and assess impact of skin involvement on health-related quality of life (HRQoL). Methods Participant…

Improving organisation to improve care: ERN ReCONNET organisational reference model for systemic sclerosis patients’ care pathway Open

Rosaria Talarico, Diana Marinello, Ilaria Palla, Sara Cannizzo, Ilaria Galetti , et al. · 2024

Objective: To optimise the organisation of care and encourage the adoption of good clinical practices, the RarERN Path © methodology was designed within ERN ReCONNET. The aim of our work was to report the application of RarERN Path © on sy…

The 2024 British Society for Rheumatology guideline for management of systemic sclerosis—executive summary Open

Christopher P. Denton, Enrico De Lorenzis, Elen Roblin, Nina Goldman, Begonya Alcacer‐Pitarch , et al. · 2024

This guideline was developed according to the British Society for Rheumatology Guidelines Protocol by a Guideline Development Group comprising healthcare professionals with expertise in SSc and people with lived experience, as well as pati…

The 2024 British Society for Rheumatology guideline for management of systemic sclerosis Open

Christopher P. Denton, Enrico De Lorenzis, Elen Roblin, Nina Goldman, Begonya Alcacer‐Pitarch , et al. · 2024

This guideline was developed according to the British Society for Rheumatology Guidelines Protocol by a Guideline Development Group comprising healthcare professionals with expertise in SSc and people with lived experience, as well as pati…

The effects of lifestyle interventions on disease activity and quality of life in patients with systemic lupus erythematosus: A systematic review Open

Bettina C Geertsema-Hoeve, Ariane A. Sickinghe, S J van Schaik-Mast, Julia Spierings, Jacob M. van Laar , et al. · 2024

Various lifestyle interventions influence quality of life in SLE patients. Consistent with recent guidelines, both exercise and psychotherapy may positively impact the health-related quality of life in these patients. However, some studies…

Multimodal imaging of structural damage and inflammation in psoriatic arthritis: a comparison of DMARD-naive and DMARD-failure patients Open

Nağme Ö Renkli, Nienke J. Kleinrensink, Julia Spierings, S.C. Mastbergen, Harald E. Vonkeman , et al. · 2024

Objectives To compare inflammatory and structural differences in active PsA between DMARD-naive and DMARD-failure patients using diverse imaging approaches for future analyses. Additionally, to explore the influence of patient characterist…

Preventive effects of early immunosuppressive treatment on the development of interstitial lung disease in systemic sclerosis Open

Arthiha Velauthapillai, Merle F. R. Bootsma, Cosimo Bruni, Christina Bergmann, Marco Matucci‐Cerinic , et al. · 2024

Background Hypothesizing that early treatment yields improved prognosis, we aimed to investigate how the timing of immunosuppressive treatment relates to interstitial lung disease (ILD) development and the course of pulmonary function in s…

P139 Self-assessment of scleroderma skin: validation of the PASTUL questionnaire Open

Julia Spierings, Voon H Ong, Paco M J Welsing, Michael Hughes, John D Pauling , et al. · 2024

Background/Aims The PASTUL (Patient self-Assessment of Skin Thickness in Upper Limb) questionnaire was developed during the COVID pandemic to allow self-assessment of skin remotely in systemic sclerosis (SSc). The aim of this study was to …

The effect of nasal Staphylococcus aureus colonization and antibiotic treatment on disease activity in ANCA associated vasculitis Open

Caroline M. Schaap, Roline M. Krol, Hilde H.F. Remmelts, Ruth Klaasen, Christiaan Hagen , et al. · 2024

Objective: The aim of this study was to identify the role of nasal Staphylococcus aureus (S. aureus) colonization and the effect of systemic or local antibiotic treatment on disease activity in patients with antineutrophil cytoplasmic anti…

Management of Disease Progression after Autologous Hematopoietic Stem Cell Transplantation in Systemic Sclerosis: Results from an International Questionnaire-Based Study Open

Julia Spierings, Giulia Bandini, Yannick Allanore, Nicoletta Del Papa, Christopher Denton , et al. · 2024

Increased vascular inflammation on PET/CT in psoriatic arthritis patients in comparison with controls Open

Nienke J. Kleinrensink, Julia Spierings, Harald E. Vonkeman, Negina Seddiqi, Amin Herman , et al. · 2024

Background Patients with psoriatic arthritis (PsA) have an increased risk of cardiovascular disease, possibly due to a chronic inflammatory state. Objectives The main objective of this study was to investigate the difference in vascular in…

Involvement of the systemic microcirculation in pediatric uveitis Open

Carlyn V. Kouwenberg, Julia Spierings, Evianne L. de Groot, Joke H. de Boer, Viera Kalinina Ayuso · 2023

Background Pediatric uveitis is a severe inflammatory ocular condition that can lead to sight-threatening complications and can negatively impact quality of life. The retinal microcirculation is often affected in intermediate uveitis and p…

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