Julia Steitz
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View article: Animal models in preclinical metastatic breast cancer immunotherapy research: A systematic review and meta-analysis of efficacy outcomes
Animal models in preclinical metastatic breast cancer immunotherapy research: A systematic review and meta-analysis of efficacy outcomes Open
Breast cancer, particularly metastatic breast cancer (MBC), presents aggressive clinical challenges with limited treatment success. Immunotherapy has emerged as a promising approach, however, discrepancies between preclinical animal models…
View article: Supplementary Figures 1-2 from Immune Cell–Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation
Supplementary Figures 1-2 from Immune Cell–Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation Open
PDF file 309K, Results of repeated dose acute toxicity study
View article: Data from Immune Cell–Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation
Data from Immune Cell–Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation Open
Infiltration of human melanomas with cytotoxic immune cells correlates with spontaneous type I IFN activation and a favorable prognosis. Therapeutic blockade of immune-inhibitory receptors in patients with preexisting lymphocytic infiltrat…
View article: Data from Immune Cell–Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation
Data from Immune Cell–Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation Open
Infiltration of human melanomas with cytotoxic immune cells correlates with spontaneous type I IFN activation and a favorable prognosis. Therapeutic blockade of immune-inhibitory receptors in patients with preexisting lymphocytic infiltrat…
View article: Supplementary Figures 1-2 from Immune Cell–Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation
Supplementary Figures 1-2 from Immune Cell–Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation Open
PDF file 309K, Results of repeated dose acute toxicity study
View article: Supplementary Table 1 from Immune Cell–Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation
Supplementary Table 1 from Immune Cell–Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation Open
XLS file 28K, List of top 50 interferon alpha induced gene across five humane melanoma cell lines
View article: Supplementary Table 1 from Immune Cell–Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation
Supplementary Table 1 from Immune Cell–Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation Open
XLS file 28K, List of top 50 interferon alpha induced gene across five humane melanoma cell lines
View article: GLP-2 as an indicator and modulator of acute inflammation improves cardiac function and survival in sepsis
GLP-2 as an indicator and modulator of acute inflammation improves cardiac function and survival in sepsis Open
Purpose GLP-1 and GLP-2 (glucagon-like peptide-1/2) are gut hormones secreted in response to food. While GLP-1 controls glucose metabolism, GLP-2 is a local gut growth factor regulating intestinal nutrient absorption. GLP-2 has been found …
View article: Effects of asparaginases and L-carnitine on Western-diet-induced hepatosteatosis in mice
Effects of asparaginases and L-carnitine on Western-diet-induced hepatosteatosis in mice Open
Background: Asparaginases are common chemotherapeutic agents used for the treatment of acute lymphoblastic leukemia as a single or combinational therapy. Accompanying hepatotoxicity makes its use in elderly patients with pre-conditions, as…
View article: ITIH5-Derived Polypeptides Covering the VIT Domain Suppress the Growth of Human Cancer Cells In Vitro
ITIH5-Derived Polypeptides Covering the VIT Domain Suppress the Growth of Human Cancer Cells In Vitro Open
Oncogenic drivers such as mutated EGFR are the preferred targets in modern drug development. However, restoring the lost function of tumor suppressor proteins could also be a valid approach to combatting cancer. ITIH5 has been revealed as …
View article: ARRIVE Guidelines checklist for ' Effects of asparaginases and L-carnitine on Western-diet-induced hepatosteatosis in mice'.
ARRIVE Guidelines checklist for ' Effects of asparaginases and L-carnitine on Western-diet-induced hepatosteatosis in mice'. Open
Study of the effect of asparaginases and L-carnitine on Westrn- diet-induced hepatosteatosis in mice
View article: Measured parameters of dose escalation study of Oncaspar
Measured parameters of dose escalation study of Oncaspar Open
Results of dose escalation study using 3 different doses of Oncaspar.
View article: ARRIVE Guidelines checklist
ARRIVE Guidelines checklist Open
Study of the effect of asparaginases and L-carnitine on Westrn- diet-induced hepatosteatosis in mice
View article: Dose escalation of Oncaspar parameters
Dose escalation of Oncaspar parameters Open
Results of dose escalation study using 3 different doses of Oncaspar.
View article: ARRIVE Guidelines checklist for ' Effects of asparaginases and L-carnitine on Western-diet-induced hepatosteatosis in mice'.
ARRIVE Guidelines checklist for ' Effects of asparaginases and L-carnitine on Western-diet-induced hepatosteatosis in mice'. Open
Study of the effect of asparaginases and L-carnitine on Westrn- diet-induced hepatosteatosis in mice
View article: Novel <i>In Vitro</i> Study to Assess Microbial Barrier Properties of Polyurethane‐Based Tissue Adhesives in Comparison to the Gold Standard Dermabond®
Novel <i>In Vitro</i> Study to Assess Microbial Barrier Properties of Polyurethane‐Based Tissue Adhesives in Comparison to the Gold Standard Dermabond® Open
Tissue adhesives as a physical barrier to microorganism penetration provide an alternative method with many advantages for wound closure in surgical settings compared to the clinical standard. This raises the need of developing and conduct…
View article: Intra-iliac bone marrow injection as a novel alternative to intra-tibial inoculation in rat model
Intra-iliac bone marrow injection as a novel alternative to intra-tibial inoculation in rat model Open
Background Intra-bone marrow injection (IBMI) in rats is adopted in many studies for stem cell and hematopoietic cell transplantation. IBMI in the tibia or the femur results in severe distress to the animal. Therefore, this study aims to e…
View article: Measured parameters of dose escalation of Oncaspar
Measured parameters of dose escalation of Oncaspar Open
Results of dose escalation study using 3 different doses of Oncaspar.
View article: Measured parameters of L-asparaginase experiment at the 28-days time point.
Measured parameters of L-asparaginase experiment at the 28-days time point. Open
% of body weight changes, clinical chemistry parameters and White blood cell count were anaylsed
View article: Results of histopathological analysis
Results of histopathological analysis Open
Results of histopathological analysis of dose escalation study of Oncaspar, L-asparaginase experiment at 4 day and 28 days time points.
View article: Measured parameters in L-asparaginase experiment
Measured parameters in L-asparaginase experiment Open
Measurement of % of body weight changes , White blood cells, and clinical chemistry parameters at the4-day in sera of male mice treated with L-asparaginase.
View article: Results
Results Open
Results of dose escalation study using 3 different doses of Oncaspar.
View article: Measured parameters in L-asparaginase experiment at 4 days time point
Measured parameters in L-asparaginase experiment at 4 days time point Open
Measurement of % of body weight changes , White blood cells, and clinical chemistry parameters at the4-day in sera of male mice treated with L-asparaginase.
View article: The Impact of a Nitric Oxide Synthase Inhibitor (L-NAME) on Ischemia–Reperfusion Injury of Cholestatic Livers by Pringle Maneuver and Liver Resection after Bile Duct Ligation in Rats
The Impact of a Nitric Oxide Synthase Inhibitor (L-NAME) on Ischemia–Reperfusion Injury of Cholestatic Livers by Pringle Maneuver and Liver Resection after Bile Duct Ligation in Rats Open
The Pringle maneuver (PM) has been widely used to control blood loss during liver resection. However, hepatic inflow occlusion can also result in hepatic ischemia–reperfusion injury (IRI), especially in patients with a cholestatic, fibroti…
View article: ITIH5 mediates epigenetic reprogramming of breast cancer cells
ITIH5 mediates epigenetic reprogramming of breast cancer cells Open
Our results provide evidence that ITIH5 triggers a reprogramming of breast cancer cells with known stem CSC properties towards an epithelial-like phenotype through global epigenetic changes effecting known tumor suppressor genes like DAPK1…
View article: Supplementary Material for: The Aachen Minipig: Phenotype, Genotype, Hematological and Biochemical Characterization, and Comparison to the Göttingen Minipig
Supplementary Material for: The Aachen Minipig: Phenotype, Genotype, Hematological and Biochemical Characterization, and Comparison to the Göttingen Minipig Open
Background: The pig is one of the most frequently used large animal models for biomedical research, especially in the field of translational research and surgical models. While standard livestock breeds are used in short-term and acute stu…