Julia W. Morriss
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View article: Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma
Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma Open
View article: 115 Spatial dissection of T cell clonotype identity, transcriptional profiles, and cell-cell interactions in the tumor microenvironment and tertiary lymphoid structures
115 Spatial dissection of T cell clonotype identity, transcriptional profiles, and cell-cell interactions in the tumor microenvironment and tertiary lymphoid structures Open
Background Determining the spatial interactions of T cell clonotypes in tumor microenvironments and tertiary lymphoid structures (TLSs) is essential to understanding adaptive anti-tumoral immune responses, but existing spatial sequencing m…
View article: Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response
Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response Open
View article: Drug addiction mutations unveil a repressive methylation ceiling in EZH2-mutant lymphoma
Drug addiction mutations unveil a repressive methylation ceiling in EZH2-mutant lymphoma Open
Drug addiction, a phenomenon where cancer cells paradoxically depend on continuous drug treatment for survival, has uncovered cell signaling mechanisms and cancer co-dependencies. Here, we discover mutations that confer drug addiction to i…
View article: Drug addiction mutations unveil a methylation ceiling in EZH2-mutant lymphoma
Drug addiction mutations unveil a methylation ceiling in EZH2-mutant lymphoma Open
Cancer mutations in Polycomb Repressive Complex 2 (PRC2) drive aberrant epigenetic states. Although therapies inhibiting the PRC2 enzymatic component EZH2 are FDA-approved, oncogene-specific dependencies remain to be discovered. Here, we i…
View article: Spatial genomics enables multi-modal study of clonal heterogeneity in tissues
Spatial genomics enables multi-modal study of clonal heterogeneity in tissues Open
View article: 76 Spatial mapping of T cell receptors and transcriptomes in renal cell carcinoma following immune checkpoint inhibitor therapy
76 Spatial mapping of T cell receptors and transcriptomes in renal cell carcinoma following immune checkpoint inhibitor therapy Open
Background Because conventional single-cell strategies rely on dissociating tissues into suspensions that lose spatial context, 1 we developed Slide-TCR-seq to sequence both whole transcriptomes and TCRs with 10µm-spatial resolution, & app…
View article: Structural Insights from HIV-Antibody Coevolution and Related Immunization Studies
Structural Insights from HIV-Antibody Coevolution and Related Immunization Studies Open
Human immunodeficiency virus type 1 (HIV-1) is a rapidly evolving pathogen that causes acquired immunodeficiency syndrome (AIDS) in humans. There are ∼30-35 million people infected with HIV around the world, and ∼25 million have died since…