Julia Wiersinga
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View article: Hypertension and orthostatic hypotension in the elderly: a challenging balance
Hypertension and orthostatic hypotension in the elderly: a challenging balance Open
Hypertension and orthostatic hypotension (OH) frequently coexist in the older population, both stemming from impaired blood pressure (BP) regulation. Managing hypertension in patients with OH presents a significant clinical challenge, part…
View article: Cerebral small vessel disease and its relationship with all-cause mortality risk: Results from the Amsterdam Ageing cohort
Cerebral small vessel disease and its relationship with all-cause mortality risk: Results from the Amsterdam Ageing cohort Open
Radiographic CSVD presence is prevalent and its integration into daily care is important as it is independently linked to increased all-cause mortality in geriatric outpatients.
View article: Orthostatic hypotension and cerebral small vessel disease: A systematic review
Orthostatic hypotension and cerebral small vessel disease: A systematic review Open
Orthostatic hypotension(OH) is highly prevalent in ageing populations and may contribute to cognitive decline through cerebral small vessel disease(CSVD). Research on the association between OH and CSVD is fragmented and inconsistent. We s…
View article: Developing blood-brain barrier arterial spin labelling as a non-invasive early biomarker of Alzheimer’s disease (DEBBIE-AD): a prospective observational multicohort study protocol
Developing blood-brain barrier arterial spin labelling as a non-invasive early biomarker of Alzheimer’s disease (DEBBIE-AD): a prospective observational multicohort study protocol Open
Introduction Loss of blood-brain barrier (BBB) integrity is hypothesised to be one of the earliest microvascular signs of Alzheimer’s disease (AD). Existing BBB integrity imaging methods involve contrast agents or ionising radiation, and p…
View article: Vascular phenotypes in memory clinic patients; preliminary results of the VARIATION study
Vascular phenotypes in memory clinic patients; preliminary results of the VARIATION study Open
Introduction: It is known that vascular damage is associated with decreased brain health. Therefore, the study VARIATION, focusing on vascular phenotypes in patients visiting a memory clinic, was launched as a substudy of the Amsterdam Age…
View article: Cardiovascular risk and all-cause mortality in a memory clinic population
Cardiovascular risk and all-cause mortality in a memory clinic population Open
Introduction: The prevalence of atherosclerotic cardiovascular diseases and its associated mortality are increasing worldwide. In persons with cognitive impairment, the potential benefits from treatment of hypertension and dyslipidaemia ma…
View article: DEveloping BBB-ASL as non-Invasive Early biomarker of Alzheimer's Disease (DEBBIE-AD): Study design
DEveloping BBB-ASL as non-Invasive Early biomarker of Alzheimer's Disease (DEBBIE-AD): Study design Open
Introduction: Arterial spin labeling (ASL) MRI, a non-invasive technique for imaging perfusion, now allows studying BBB permeability. The DEveloping BBB-ASL as a non-Invasive Early biomarker of Alzheimer's Disease (DEBBIE-AD) multi-cohort …
View article: Managing older patients with heart failure calls for a holistic approach
Managing older patients with heart failure calls for a holistic approach Open
Aims This study aims to assess the presence of geriatric domain impairments in an older heart failure (HF) outpatient population and to relate these domain impairments with 1 year mortality risk in comparison with a geriatric outpatient po…
View article: The relevance of a multidomain geriatric assessment in older patients with heart failure
The relevance of a multidomain geriatric assessment in older patients with heart failure Open
Aims Physical frailty screening is more commonly performed at outpatient heart failure (HF) clinics. However, this does not incorporate other common geriatric domains. This study assesses whether a multidomain geriatric assessment, in comp…