Julia Mergner
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View article: Multicenter evaluation of label-free quantification in human plasma on a high dynamic range benchmark set
Multicenter evaluation of label-free quantification in human plasma on a high dynamic range benchmark set Open
View article: Correction to “Multicenter Longitudinal Quality Assessment of MS-Based Proteomics in Plasma and Serum”
Correction to “Multicenter Longitudinal Quality Assessment of MS-Based Proteomics in Plasma and Serum” Open
View article: Barley resistance and susceptibility to fungal cell entry involve the interplay of <scp>ROP</scp> signaling with phosphatidylinositol‐monophosphates
Barley resistance and susceptibility to fungal cell entry involve the interplay of <span>ROP</span> signaling with phosphatidylinositol‐monophosphates Open
SUMMARY Rho‐of‐plant small GTPases (ROPs) are regulators of plant polar growth and of plant–pathogen interactions. The barley ROP, RACB, is involved in susceptibility toward infection by the barley powdery mildew fungus Blumeria hordei ( B…
View article: Structural basis for OAS2 regulation and its antiviral function
Structural basis for OAS2 regulation and its antiviral function Open
Oligoadenylate synthetase (OAS) proteins are immune sensors for double-stranded RNA and are critical for restricting viruses. OAS2 comprises two OAS domains, only one of which can synthesize 2'-5'-oligoadenylates for RNase L activation. Ex…
View article: Sexual reproduction in land plants: an evolutionary perspective
Sexual reproduction in land plants: an evolutionary perspective Open
Key message We link key aspects of land plant reproductive evolution and detail how successive molecular changes leading to novel tissues and organs require co-evolution of communication systems between tissues. Abstract The transition of …
View article: Head and neck squamous cell carcinoma-derived extracellular vesicles mediate Ca²⁺-dependent platelet activation and aggregation through tissue factor
Head and neck squamous cell carcinoma-derived extracellular vesicles mediate Ca²⁺-dependent platelet activation and aggregation through tissue factor Open
Background Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy, characterized by poor clinical outcomes, primarily driven by high rate of locoregional recurrence and metastasis. Extensive heterogeneity among the tumor…
View article: Head and neck squamous cell carcinoma-derived extracellular vesicles mediate Ca²⁺-dependent platelet activation and aggregation through tissue factor
Head and neck squamous cell carcinoma-derived extracellular vesicles mediate Ca²⁺-dependent platelet activation and aggregation through tissue factor Open
Background Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy, characterized by poor clinical outcomes, primarily driven by high rate of locoregional recurrence and metastasis. Extensive heterogeneity among the tumor…
View article: Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics
Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics Open
Ferroptosis and apoptosis are widely considered to be independent cell death modalities. Ferroptotic cell death is a consequence of insufficient radical detoxification and progressive lipid peroxidation, which is counteracted by glutathion…
View article: Oncogenic and microenvironmental signals drive cell type specific apoptosis resistance in juvenile myelomonocytic leukemia
Oncogenic and microenvironmental signals drive cell type specific apoptosis resistance in juvenile myelomonocytic leukemia Open
Juvenile myelomonocytic leukemia (JMML) is caused by constitutively activated RAS signaling and characterized by increased proliferation and predominant myelomonocytic differentiation of hematopoietic cells. Using MxCre;Ptpn11 D61Y /+ mice…
View article: Apoptotic caspases silence spontaneous innate immune signals by specifically cleaving activated mitochondrial antiviral signalling protein (MAVS)
Apoptotic caspases silence spontaneous innate immune signals by specifically cleaving activated mitochondrial antiviral signalling protein (MAVS) Open
Summary Caspases-9, -3 and -7 are activated in the mitochondrial apoptosis pathway and lead to the apoptotic phenotype. Caspases also function to limit inflammation upon apoptotic mitochondrial permeabilization through degradation of the s…
View article: Multicenter Longitudinal Quality Assessment of MS-Based Proteomics in Plasma and Serum
Multicenter Longitudinal Quality Assessment of MS-Based Proteomics in Plasma and Serum Open
Advancing MS-based proteomics toward clinical applications evolves around developing standardized start-to-finish and fit-for-purpose workflows for clinical specimens. Steps along the method design involve the determination and optimizatio…
View article: Structural Basis for OAS2 Regulation and its Antiviral Function
Structural Basis for OAS2 Regulation and its Antiviral Function Open
Summary Oligoadenylate synthetase (OAS) proteins are immune sensors for double-stranded RNA and critical for restricting viruses. OAS2 comprises two OAS domains, only one of which can synthesize 2’-5’-oligoadenylates for RNase L activation…
View article: ARID1A mutations protect follicular lymphoma from FAS-dependent immune surveillance by reducing RUNX3/ETS1-driven FAS-expression
ARID1A mutations protect follicular lymphoma from FAS-dependent immune surveillance by reducing RUNX3/ETS1-driven FAS-expression Open
View article: Two-layered immune escape in AML is overcome by Fcγ receptor activation and inhibition of PGE2 signaling in NK cells
Two-layered immune escape in AML is overcome by Fcγ receptor activation and inhibition of PGE2 signaling in NK cells Open
Loss of anticancer natural killer (NK) cell function in patients with acute myeloid leukemia (AML) is associated with fatal disease progression and remains poorly understood. Here, we demonstrate that AML blasts isolated from patients rapi…
View article: Multicenter Evaluation of Label-Free Quantification in Human Plasma: Benchmarking with a High Dynamic Range Multispecies Sample Set
Multicenter Evaluation of Label-Free Quantification in Human Plasma: Benchmarking with a High Dynamic Range Multispecies Sample Set Open
Human plasma is routinely collected during clinical care and constitutes a rich source of biomarkers for diagnostics and patient stratification. Liquid chromatography-mass spectrometry (LC-MS)-based proteomics is a key method for plasma bi…
View article: Barley resistance and susceptibility to fungal cell entry involve the interplay of ROP signaling with phosphatidylinositol-monophosphates
Barley resistance and susceptibility to fungal cell entry involve the interplay of ROP signaling with phosphatidylinositol-monophosphates Open
Rho-of-plant small GTPases (ROPs) are regulators of plant polar growth and of plant-pathogen interactions. The barley ROP, RACB, is involved in susceptibility towards infection by the barley powdery mildew fungus Blumeria hordei ( Bh ) but…
View article: Multi-omics characterization of the monkeypox virus infection
Multi-omics characterization of the monkeypox virus infection Open
Multiple omics analyzes of Vaccinia virus (VACV) infection have defined molecular characteristics of poxvirus biology. However, little is known about the monkeypox (mpox) virus (MPXV) in humans, which has a different disease manifestation …
View article: Neocarzilin Inhibits Cancer Cell Proliferation via BST-2 Degradation, Resulting in Lipid Raft-Trapped EGFR
Neocarzilin Inhibits Cancer Cell Proliferation via BST-2 Degradation, Resulting in Lipid Raft-Trapped EGFR Open
Neocarzilin (NCA) is a natural product exhibiting potent antimigratory as well as antiproliferative effects. While vesicle amine transport protein 1 (VAT-1) was previously shown to inhibit migration upon NCA binding, the molecular mechanis…
View article: Integrating multi‐omics data reveals energy and stress signaling activated by abscisic acid in Arabidopsis
Integrating multi‐omics data reveals energy and stress signaling activated by abscisic acid in Arabidopsis Open
SUMMARY Phytohormones are essential signaling molecules regulating various processes in growth, development, and stress responses. Genetic and molecular studies, especially using Arabidopsis thaliana (Arabidopsis), have discovered many imp…
View article: Transport properties of canonical PIN-FORMED proteins and the role of the loop domain in auxin transport
Transport properties of canonical PIN-FORMED proteins and the role of the loop domain in auxin transport Open
Indole-3-acetic acid (IAA), the most abundant endogenous auxin is transported in plants in a polar fashion by PIN-FORMED (PIN) transporters and controls virtually all plant growth and developmental processes. Canonical PINs possess a long …
View article: D6PK plasma membrane polarity requires a repeated CXX(X)P motif and PDK1-dependent phosphorylation
D6PK plasma membrane polarity requires a repeated CXX(X)P motif and PDK1-dependent phosphorylation Open
D6 PROTEIN KINASE (D6PK) is a polarly localized plasma-membrane-associated kinase from Arabidopsis thaliana that activates polarly distributed PIN-FORMED auxin transporters. D6PK moves rapidly to and from the plasma membrane, independent o…
View article: The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize
The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize Open
Autocrine signaling pathways regulated by RAPID ALKALINIZATION FACTORs (RALFs) control cell wall integrity during pollen tube germination and growth in Arabidopsis (Arabidopsis thaliana). To investigate the role of pollen-specific RALFs in…
View article: <i>ARID1A</i>Mutations Protect Follicular Lymphoma from FAS-dependent Immune Surveillance by Reducing RUNX3/ETS1-Driven FAS-Expression
<i>ARID1A</i>Mutations Protect Follicular Lymphoma from FAS-dependent Immune Surveillance by Reducing RUNX3/ETS1-Driven FAS-Expression Open
The cell death receptor FAS and its ligand (FASLG) play crucial roles in the selection of B cells during the germinal center (GC) reaction. Failure to eliminate potentially harmful B cells via FAS can lead to lymphoproliferation and the de…
View article: Multicenter Collaborative Study to Optimize Mass Spectrometry Workflows of Clinical Specimens
Multicenter Collaborative Study to Optimize Mass Spectrometry Workflows of Clinical Specimens Open
The foundation for integrating mass spectrometry (MS)-based proteomics into systems medicine is the development of standardized start-to-finish and fit-for-purpose workflows for clinical specimens. An essential step in this pursuit is to h…
View article: MDM2 Influences ACE2 Stability and SARS-CoV-2 Uptake
MDM2 Influences ACE2 Stability and SARS-CoV-2 Uptake Open
Angiotensin-converting enzyme 2 (ACE2) is the central entry receptor for SARS-CoV-2. However, surprisingly little is known about the effects of host regulators on ACE2 localization, expression, and the associated influence on SARS-CoV-2 in…
View article: High-Throughput Screening and Proteomic Characterization of Compounds Targeting Myeloid-Derived Suppressor Cells
High-Throughput Screening and Proteomic Characterization of Compounds Targeting Myeloid-Derived Suppressor Cells Open
View article: NF-κB c-REL-OTUD4 axis regulates B-cell receptor in B-cell lymphoma
NF-κB c-REL-OTUD4 axis regulates B-cell receptor in B-cell lymphoma Open
Summary The B-cell receptor (BCR) is essential for B-cell development and a crucial clinical target in immuno-oncology. However, therapeutic success against the BCR and downstream signaling pathways is hampered by enhanced NF-κB activation…
View article: The RALF Signaling Pathway Regulates Cell Wall Integrity during Pollen Tube Growth in Maize
The RALF Signaling Pathway Regulates Cell Wall Integrity during Pollen Tube Growth in Maize Open
Autocrine signaling pathways regulated by RAPID ALKALINIZATION FACTORs (RALFs) control cell wall integrity during pollen tube germination and growth in Arabidopsis. To investigate the role of pollen-specific RALFs in another plant species,…
View article: Hepatitis B Virus Targets Lipid Transport Pathways to Infect Hepatocytes
Hepatitis B Virus Targets Lipid Transport Pathways to Infect Hepatocytes Open
View article: Posttranslational modification of the RHO of plants protein RACB by phosphorylation and cross-kingdom conserved ubiquitination
Posttranslational modification of the RHO of plants protein RACB by phosphorylation and cross-kingdom conserved ubiquitination Open
Small RHO-type G-proteins act as signaling hubs and master regulators of polarity in eukaryotic cells. Their activity is tightly controlled, as defective RHO signaling leads to aberrant growth and developmental defects. Two major processes…