Julia Z. Adamska
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View article: A SARS-CoV-2 vaccine on an NIR-II/SWIR emitting nanoparticle platform
A SARS-CoV-2 vaccine on an NIR-II/SWIR emitting nanoparticle platform Open
The COVID-19 pandemic caused a global health crisis that resulted in millions of deaths. Effective vaccines have played central roles in curtailing the pandemic. Here, we developed a down-converting near-infrared IIb (NIR-IIb; 1500 to 1700…
View article: Saponin nanoparticle adjuvants incorporating Toll-like receptor agonists drive distinct immune signatures and potent vaccine responses
Saponin nanoparticle adjuvants incorporating Toll-like receptor agonists drive distinct immune signatures and potent vaccine responses Open
Over the past few decades, the development of potent and safe immune-activating adjuvant technologies has become the heart of intensive research in the constant fight against highly mutative and immune evasive viruses such as influenza, se…
View article: Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis
Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis Open
Molecular markers of autoimmunity, such as antibodies to citrullinated protein antigens (ACPA), are detectable prior to inflammatory arthritis (IA) in rheumatoid arthritis (RA) and may define a state that is ‘at-risk’ for future RA. Here w…
View article: <scp>A‐to‐I RNA</scp> editing by <scp>ADAR</scp> and its therapeutic applications: From viral infections to cancer immunotherapy
<span>A‐to‐I RNA</span> editing by <span>ADAR</span> and its therapeutic applications: From viral infections to cancer immunotherapy Open
ADAR deaminases catalyze adenosine‐to‐inosine (A‐to‐I) editing on double‐stranded RNA (dsRNA) substrates that regulate an umbrella of biological processes. One of the two catalytically active ADAR enzymes, ADAR1, plays a major role in inna…
View article: Saponin Nanoparticle Adjuvants Incorporating Toll-Like Receptor Agonists Drive Distinct Immune Signatures and Potent Vaccine Responses
Saponin Nanoparticle Adjuvants Incorporating Toll-Like Receptor Agonists Drive Distinct Immune Signatures and Potent Vaccine Responses Open
Over the past few decades, the development of potent and safe immune-activating adjuvant technologies has become the heart of intensive research in the constant fight against highly mutative and immune evasive viruses such as influenza, SA…
View article: Artificial awareness, as an innovative learning method and its application in science and technology
Artificial awareness, as an innovative learning method and its application in science and technology Open
The creation of the information society is associated with the creation of new intellectual, cultural, spiritual and material values, as well as with new principles and methods of social and interpersonal communication. Achieving this goal…
View article: Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens early immunity against SARS-CoV-2
Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens early immunity against SARS-CoV-2 Open
Under normal homeostatic conditions, self-double-stranded RNA (self-dsRNA) is modified by adenosine deaminase acting on RNA 1 (ADAR1) to prevent the induction of a type I interferon-mediated inflammatory cascade. Antigen-presenting cells (…
View article: SREBP signaling is essential for effective B cell responses
SREBP signaling is essential for effective B cell responses Open
View article: Myeloablative autologous haematopoietic stem cell transplantation resets the B cell repertoire to a more naïve state in patients with systemic sclerosis
Myeloablative autologous haematopoietic stem cell transplantation resets the B cell repertoire to a more naïve state in patients with systemic sclerosis Open
Together, these findings suggest that myeloablative autologous HSCT resets the IGH repertoire to a more naïve state characterised by IgM-expressing B cells, providing a possible mechanism for the elimination of pathogenic B cells that may …
View article: Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine Open
View article: Quantum-Information Processes in Awareness Management
Quantum-Information Processes in Awareness Management Open
Human mental life is a form of existence of information not only electromagnetic, but also acoustic, spin, soliton and bioplasm. That is, the layout the biological human in addition to the biochemical way uses the message of information us…
View article: On the distribution of the product of two continuous random variables\n with an application to electricity market transactions. Finite and\n infinite-variance case
On the distribution of the product of two continuous random variables\n with an application to electricity market transactions. Finite and\n infinite-variance case Open
In this paper we study the distribution of a product of two continuous random\nvariables. We derive formulas for the probability density functions and moments\nof the products of the Gaussian, log-normal, Student's t and Pareto random\nvar…
View article: Hydrogel‐Based Slow Release of a Receptor‐Binding Domain Subunit Vaccine Elicits Neutralizing Antibody Responses Against SARS‐CoV‐2
Hydrogel‐Based Slow Release of a Receptor‐Binding Domain Subunit Vaccine Elicits Neutralizing Antibody Responses Against SARS‐CoV‐2 Open
The development of effective vaccines that can be rapidly manufactured and distributed worldwide is necessary to mitigate the devastating health and economic impacts of pandemics like COVID‐19. The receptor‐binding domain (RBD) of the SARS…
View article: Neutralizing anti–IL-1 receptor antagonist autoantibodies induce inflammatory and fibrotic mediators in IgG4-related disease
Neutralizing anti–IL-1 receptor antagonist autoantibodies induce inflammatory and fibrotic mediators in IgG4-related disease Open
View article: Hydrogel-based slow release of a receptor-binding domain subunit vaccine elicits neutralizing antibody responses against SARS-CoV-2
Hydrogel-based slow release of a receptor-binding domain subunit vaccine elicits neutralizing antibody responses against SARS-CoV-2 Open
The development of effective vaccines that can be rapidly manufactured and distributed worldwide is necessary to mitigate the devastating health and economic impacts of pandemics like COVID-19. The receptor-binding domain (RBD) of the SARS…
View article: Modeling human adaptive immune responses with tonsil organoids
Modeling human adaptive immune responses with tonsil organoids Open
View article: Distinct immune characteristics distinguish hereditary and idiopathic chronic pancreatitis
Distinct immune characteristics distinguish hereditary and idiopathic chronic pancreatitis Open
Chronic pancreatitis (CP) is considered an irreversible fibroinflammatory pancreatic disease. Despite numerous animal model studies, questions remain about local immune characteristics in human CP. We profiled pancreatic immune cell charac…
View article: B cells in rheumatoid arthritis synovial tissues encode focused antibody repertoires that include antibodies that stimulate macrophage TNF-α production
B cells in rheumatoid arthritis synovial tissues encode focused antibody repertoires that include antibodies that stimulate macrophage TNF-α production Open
View article: Robust B Cell Responses Predict Rapid Resolution of Lyme Disease
Robust B Cell Responses Predict Rapid Resolution of Lyme Disease Open
Lyme disease (Borrelia burgdorferi infection) is increasingly recognized as a significant source of morbidity worldwide. Here, we show that blood plasmablasts and CD27- memory B cells are elevated in untreated Lyme diseas…
View article: AB010. OS02.04. Characterization of autoantibody in thymoma with myasthenia gravis by single-cell sequencing of B-cells
AB010. OS02.04. Characterization of autoantibody in thymoma with myasthenia gravis by single-cell sequencing of B-cells Open
Thymomas are frequently associated with paraneoplastic autoimmune syndromes, with the most common being myasthenia gravis (MG). MG is characterized by autoantibodies against muscle antigens, most frequently the acetylcholine receptor (AChR…
View article: Mobile System for Optical Music Recognition and Music Sound Generation
Mobile System for Optical Music Recognition and Music Sound Generation Open