João F. Pinto
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View article: Material-sparing method development for liquid-to-solid ratio determination for wet granulation process development
Material-sparing method development for liquid-to-solid ratio determination for wet granulation process development Open
The liquid-to-solid (L/S) ratio is a key process parameter in wet granulation processes, which ensures that the final granules meet the desired quality attributes. Mixer torque rheometer (MTR) is an established instrument to determine this…
View article: Ethnomedicinal Usage, Phytochemistry and Pharmacological Potential of Solanum surattense Burm. f.
Ethnomedicinal Usage, Phytochemistry and Pharmacological Potential of Solanum surattense Burm. f. Open
Solanum surattense Burm. f. is a significant member of the Solanaceae family, and the Solanum genus is renowned for its traditional medicinal uses and bioactive potential. This systematic review adheres to PRISMA methodology, analyzing sci…
View article: Exploring Environmental Settings to Improve the Printability of Paroxetine-Loaded Filaments by Fused Deposition Modelling
Exploring Environmental Settings to Improve the Printability of Paroxetine-Loaded Filaments by Fused Deposition Modelling Open
The successful integration of hot-melt extrusion (HME) and fused deposition modelling (FDM) depends on a better understanding of the impact of environmental conditions on the printability of formulations, since they significantly affect th…
View article: Development of an adhesive tablet for the delivery of Diospyros villosa root for the treatment of oral cavity diseases
Development of an adhesive tablet for the delivery of Diospyros villosa root for the treatment of oral cavity diseases Open
The Diospyros villosa root extract (DVR) has the potential to treat oral cavity diseases (DOC), as confirmed by its frequent use as a toothbrush among Mozambicans. In the present work, a tablet with adhesive properties was developed with p…
View article: Selection of a Hydroxypropylcellulose Grade for 3D-Printable Paroxetine Formulations by Fused Deposition Modelling
Selection of a Hydroxypropylcellulose Grade for 3D-Printable Paroxetine Formulations by Fused Deposition Modelling Open
This work presents the preliminary development of paroxetine-based formulations containing hydroxypropylcellulose (HPC) polymers suitable for hot-melt extrusion coupled to fused deposition modeling (3D printing). Two grades of HPC (54% w/w…
View article: Digital Compounding in Pharmacies: A Pilot Stability Study
Digital Compounding in Pharmacies: A Pilot Stability Study Open
The manufacture of medicines on demand for a particular patient, at the point of care, may be achieved via 3D printing, improving therapeutic outcomes, medication adherence and patient safety. Tablets are often printed using a combination …
View article: The Genus Diospyros: A Review of Novel Insights into the Biological Activity and Species of Mozambican Flora
The Genus Diospyros: A Review of Novel Insights into the Biological Activity and Species of Mozambican Flora Open
Species of the Diospyros L. genus (Ebenaceae family) have been largely used in traditional medicine for the treatment of several diseases, especially infectious ones. To date, active major compounds such as naphthoquinones, triterpenoids, …
In vitro dissolution/permeation tools for amorphous solid dispersions bioavailability forecasting II: Comparison and mechanistic insights Open
Along with the increasing demand for complex formulations comes the need for appropriate in vitro methodologies capable of predicting their corresponding in vivo performance and the mechanisms controlling the drug release which can impact …
View article: Production of Bi-Compartmental Tablets by FDM 3D Printing for the Withdrawal of Diazepam
Production of Bi-Compartmental Tablets by FDM 3D Printing for the Withdrawal of Diazepam Open
Diazepam (DZP) is a long-acting benzodiazepine to treat anxiety or acute alcohol withdrawal. Although this class of drugs should be taken for a short period of time, many patients take them for longer than recommended, which has been linke…
View article: Diospyros villosa Root Monographic Quality Studies
Diospyros villosa Root Monographic Quality Studies Open
Diospyros villosa L. (De Winter) (Ebenaceae) is a shrub whose root (DVR) is used as a toothbrush and to treat oral infections in Mozambique. The present work aims at establishing monographic quality criteria to allow the sustainable and sa…
View article: Microfluidic preparation and optimization of sorafenib-loaded poly(ethylene glycol-block-caprolactone) nanoparticles for cancer therapy applications
Microfluidic preparation and optimization of sorafenib-loaded poly(ethylene glycol-block-caprolactone) nanoparticles for cancer therapy applications Open
The use of amphiphilic block copolymers to generate colloidal delivery systems for hydrophobic drugs has been the subject of extensive research, with several formulations reaching the clinical development stages. However, to generate parti…
View article: In Situ Co-Amorphization of Olanzapine in the Matrix and on the Coat of Pellets
In Situ Co-Amorphization of Olanzapine in the Matrix and on the Coat of Pellets Open
In situ amorphization is a promising approach, considered in the present work, to enhance the solubility and dissolution rate of olanzapine, while minimizing the exposure of the amorphous material to the stress conditions applied during co…
View article: Personalised Esomeprazole and Ondansetron 3D Printing Formulations in Hospital Paediatric Environment: I-Pre-Formulation Studies
Personalised Esomeprazole and Ondansetron 3D Printing Formulations in Hospital Paediatric Environment: I-Pre-Formulation Studies Open
Individualised medicine demands the formulation of pharmacotherapy in accordance with the characteristics of each patient’s health condition, and paediatrics is one of the areas that needs this approach. The 3D printing of oral doses is on…
View article: Amorphous and Co-Amorphous Olanzapine Stability in Formulations Intended for Wet Granulation and Pelletization
Amorphous and Co-Amorphous Olanzapine Stability in Formulations Intended for Wet Granulation and Pelletization Open
The preparation of amorphous and co-amorphous systems (CAMs) effectively addresses the solubility and bioavailability issues of poorly water-soluble chemical entities. However, stress conditions imposed during common pharmaceutical process…
View article: Downstream Processing of Amorphous and Co-Amorphous Olanzapine Powder Blends
Downstream Processing of Amorphous and Co-Amorphous Olanzapine Powder Blends Open
The work evaluates the stability of amorphous and co-amorphous olanzapine (OLZ) in tablets manufactured by direct compression. The flowability and the compressibility of amorphous and co-amorphous OLZ with saccharin (SAC) and the propertie…
View article: In Vitro Evaluation of the Therapeutic Effects of Dual‐Drug Loaded Spermine‐Acetalated Dextran Nanoparticles Coated with Tannic Acid for Cardiac Applications
In Vitro Evaluation of the Therapeutic Effects of Dual‐Drug Loaded Spermine‐Acetalated Dextran Nanoparticles Coated with Tannic Acid for Cardiac Applications Open
Myocardial infarction results in a massive loss of cardiomyocytes (CMs). Unfortunately, current therapies are unsuccessful in replacing lost CMs, and thus, there is an urgent need for innovative approaches. Here, a nanosystem based on sper…
View article: Influence of the Infill Geometry of 3D-Printed Tablets on Drug Dissolution
Influence of the Infill Geometry of 3D-Printed Tablets on Drug Dissolution Open
Patient-centric therapy is especially important in pediatrics and may be attained by three-dimensional printing. Filaments containing 30% w/w of theophylline were produced by hot-melt extrusion and printed using fused deposition modelling …
View article: Assessment of the stability of co-amorphous olanzapine in tablets
Assessment of the stability of co-amorphous olanzapine in tablets Open
INTRODUCTION: Amorphous and co-amorphous (CAM) materials have recently been used to improve oral bioavailability of drugs, by enhancing water solubility and dissolution rate from solid dosage forms [1,2]. However, stress conditions imposed…
View article: Comparison of the amorphization ability of two polymorphic forms of olanzapine
Comparison of the amorphization ability of two polymorphic forms of olanzapine Open
INTRODUCTION: The production of amorphous and co-amorphous (CAM) materials has been used as a procedure to overcome the poor water solubility shown by most of the drugs currently under development [1]. Ball milling has been considered to c…
View article: Characterisation and stability of co-amorphous systems containing olanzapine and sulphonic acids
Characterisation and stability of co-amorphous systems containing olanzapine and sulphonic acids Open
INTRODUCTION: A large number of active pharmaceutical compounds currently under development are poorly water soluble, which can limit their bioavailability and results in formulation challenges [1]. Co-amorphous systems (CAMs) are known to…
View article: Co-formability, solubility enhancement and stability of olanzapine co-amorphous systems produced with different co-formers
Co-formability, solubility enhancement and stability of olanzapine co-amorphous systems produced with different co-formers Open
Introduction Strategies to address the problem of poorly water-soluble drugs encompass the conversion of a crystalline drug into an amorphous form to promote its apparent solubility and dissolution. Co-amorphous systems (CAMs) incorporate …
View article: Understanding Carrier Performance in Low-Dose Dry Powder Inhalation: An In Vitro–In Silico Approach
Understanding Carrier Performance in Low-Dose Dry Powder Inhalation: An In Vitro–In Silico Approach Open
The use of physiologically based pharmacokinetic (PBPK) models to support drug product development has become increasingly popular. The in vitro characterization of the materials of the formulation provides valuable descriptors for the in …
View article: Polymer Selection for Hot-Melt Extrusion Coupled to Fused Deposition Modelling in Pharmaceutics
Polymer Selection for Hot-Melt Extrusion Coupled to Fused Deposition Modelling in Pharmaceutics Open
Three-dimensional (3D) printing offers the greatest potential to revolutionize the future of pharmaceutical manufacturing by overcoming challenges of conventional pharmaceutical operations and focusing design and production of dosage forms…
View article: How Can Biomolecules Improve Mucoadhesion of Oral Insulin? A Comprehensive Insight using Ex-Vivo, In Silico, and In Vivo Models
How Can Biomolecules Improve Mucoadhesion of Oral Insulin? A Comprehensive Insight using Ex-Vivo, In Silico, and In Vivo Models Open
Currently, insulin can only be administered through the subcutaneous route. Due to the flaws associated with this route, it is of interest to orally deliver this drug. However, insulin delivered orally has several barriers to overcome as i…