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INVESTIGATING THE ASSOCIATION BETWEEN CLINIC VOLUME AND PRE- IMPLANTATION GENETIC TESTING (PGT) UTILIZATION IN US-BASED ASSISTED REPRODUCTIVE TECHNOLOGY (ART) PROGRAMS Open

Esther Wu, Meaghan Jain, Himanshu Gupta, Julian A. Gingold · 2025

Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation Open

Dandan Zhu, Mo-Fan Huang, An Xu, Xueqin Gao, Yuwen Huang , et al. · 2024

Comparing reproductive outcomes between conventional in vitro fertilization and nonindicated intracytoplasmic sperm injection in autologous embryo transfer cycles: a Society for Assisted Reproductive Technology Clinic Outcome Reporting System Study Open

Julian A. Gingold, Haotian Wu, Harry Lieman, Manvinder Singh, Sangita Jindal · 2023

Nonindicated ICSI was associated with reduced blastocyst availability in fresh cycles compared with IVF, leading to lower live birth rates. Outcomes from completed transfers were clinically comparable.

CONTINUOUS CLOMIPHENE RELIABLY BLOCKS LUTEINIZING HORMONE SURGE IN PATIENTS UNDERGOING IN VITRO FERTILIZATION: A RETROSPECTIVE, CROSS-SECTIONAL STUDY Open

Kendall Bielak, Julian A. Gingold, E T Myers · 2023

P-622 Age-specific reference intervals for anti-müllerian hormone in Mexico: A population-based study. implications for Latin America Open

J Rodriguez-Purata, Julian A. Gingold, M Alonso-de-Mendieta, María José Gómez-Cuesta, Enrique Cervantes-Bravo · 2023

Study question To determine the age-specific normal range of antimullerian hormone (AMH) levels in a female Latin American population. Summary answer Age-related nomograms for general population for the 3rd-97th percentiles were produced. …

Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation Open

An Xu, Mo Liu, Mo-Fan Huang, Yang Zhang, Ruifeng Hu , et al. · 2023

The microbiome and endometriosis Open

Carlos H Miyashira, Fernanda Reali Oliveira, Marina Paula Andres, Julian A. Gingold, Maurício Simões Abrão · 2022

The objective of this study was to systematically review the literature on the human microbiome in association with endometriosis. PubMed/Medline, Cochrane, and Embase databases were searched for literature published from 1986 to August 20…

Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies Open

Jian Tu, Zijun Huo, Yao Yu, Dandan Zhu, An Xu , et al. · 2022

Significance Rare human hereditary disorders provide unequivocal evidence of the role of gene mutations in human disease pathogenesis and offer powerful insights into their influence on human disease development. Using a hereditary retinob…

Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome Open

Brittany E. Jewell, An Xu, Dandan Zhu, Mo-Fan Huang, Linchao Lu , et al. · 2021

Rothmund-Thomson syndrome (RTS) is an autosomal recessive genetic disorder characterized by poikiloderma, small stature, skeletal anomalies, sparse brows/lashes, cataracts, and predisposition to cancer. Type 2 RTS patients with biallelic R…

An Esrrb and Nanog Cell Fate Regulatory Module Controlled by Feed Forward Loop Interactions Open

Ana Sevilla, Dimitri Papatsenko, Amin R. Mazloom, Huilei Xu, Ana Vasileva , et al. · 2021

Cell fate decisions during development are governed by multi-factorial regulatory mechanisms including chromatin remodeling, DNA methylation, binding of transcription factors to specific loci, RNA transcription and protein synthesis. Howev…

LncRNA H19 Suppresses Osteosarcomagenesis by Regulating snoRNAs and DNA Repair Protein Complexes Open

An Xu, Mo-Fan Huang, Dandan Zhu, Julian A. Gingold, Danielle A Bazer , et al. · 2021

Osteosarcoma is one of the most frequent common primary malignant tumors in childhood and adolescence. Long non-coding RNAs (lncRNAs) have been reported to regulate the initiation and progression of tumors. However, the exact molecular mec…

Dysregulated PJA1-TGF-β signaling in cancer stem cell-associated liver cancers Open

Jian Chen, Julian A. Gingold · 2020

The transforming growth factor beta (TGF-β) signaling pathway plays important roles in cell differentiation, stem cell modulation, organ lineage, and immune suppression. TGF-β signaling is negatively regulated by the ubiquitin-proteasome p…

Circulating Myeloid-derived Suppressor Cells Facilitate Invasion of Thyroid Cancer Cells by Repressing miR-486-3p Open

Li Chen, Li Xiong, Shubing Hong, Jin Li, Zijun Huo , et al. · 2020

Background Myeloid-derived suppressor cells (MDSCs) have become increasingly recognized as facilitators of tumor development. However, the role of MDSCs in papillary thyroid carcinoma (PTC) progression has not been clearly explored. Object…

Use of hysteroscopy in diagnosis and follow-up of acquired uterine enhanced myometrial vascularity Open

Julian A. Gingold, D.A. Bradley · 2020

Embryo Staging with Weakly-Supervised Region Selection and Dynamically-Decoded Predictions Open

Tingfung Lau, Nathan Ng, Julian A. Gingold, Nina Desai, Julian McAuley , et al. · 2019

To optimize clinical outcomes, fertility clinics must strategically select which embryos to transfer. Common selection heuristics are formulas expressed in terms of the durations required to reach various developmental milestones, quantiti…

Genomic Integrity Safeguards Self-Renewal in Embryonic Stem Cells Open

Jie Su, Dandan Zhu, Zijun Huo, Julian A. Gingold, Yen-Sin Ang , et al. · 2019

A multitude of signals are coordinated to maintain self-renewal in embryonic stem cells (ESCs). To unravel the essential internal and external signals required for sustaining the ESC state, we expand upon a set of ESC pluripotency-associat…

Immunomodulatory TGF-β Signaling in Hepatocellular Carcinoma Open

Jian Chen, Julian A. Gingold, Xiaoping Su · 2019

Embryo staging with weakly-supervised region selection and dynamically-decoded predictions Open

Tingfung Lau, Nathan Ng, Julian A. Gingold, Nina Desai, Julian McAuley , et al. · 2019

To optimize clinical outcomes, fertility clinics must strategically select which embryos to transfer. Common selection heuristics are formulas expressed in terms of the durations required to reach various developmental milestones, quantiti…

Generation of a heterozygous p53 R249S mutant human embryonic stem cell line by TALEN-mediated genome editing Open

Zijun Huo, Jian Tu, An Xu, Yan Li, Donghui Wang , et al. · 2018

As one of the most essential genome guardians, p53 and its mutants have been suggested associated with many types of cancers. Many p53 mutants function induce unique phenotypes, including carcinogenesis, metastasis, and drug resistance. Th…

African American patients with surgically managed ectopic pregnancy are less likely than white patients to be offered salpingostomy Open

Julian A. Gingold, Isabel Janmey, Laura C. Gemmell, D.A. Bradley, Tommaso Falcone · 2018

Endometriosis is a risk factor for incorrectly diagnosed laterality of ectopic pregnancy on pelvic ultrasound Open

Julian A. Gingold, Laura C. Gemmell, Isabel Janmey, Tommaso Falcone · 2018

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells Open

Ruoji Zhou, An Xu, Jian Tu, Mo Liu, Julian A. Gingold , et al. · 2018

Li-Fraumeni syndrome (LFS) is an autosomal dominant hereditary cancer disorder. Patients with LFS are predisposed to a various type of tumors, including osteosarcoma--one of the most frequent primary non-hematologic malignancies in the chi…

Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing Open

An Xu, Ruoji Zhou, Jian Tu, Zijun Huo, Dandan Zhu , et al. · 2018

Generation of human embryonic stem cell line with heterozygous RB1 deletion by CRIPSR/Cas9 nickase Open

Jian Tu, Zijun Huo, Mo Liu, Donghui Wang, An Xu , et al. · 2018

The Retinoblastoma 1 (RB1) tumor suppressor, a member of the Retinoblastoma gene family, functions as a pocket protein for the functional binding of E2F transcription factors. About 1/3 of retinoblastoma patients harbor a germline RB1 muta…

A homozygous p53 R282W mutant human embryonic stem cell line generated using TALEN-mediated precise gene editing Open

Ruoji Zhou, An Xu, Donghui Wang, Dandan Zhu, Helen Mata , et al. · 2018

The tumor suppressor gene TP53 is the most frequently mutated gene in human cancers. Many hot-spot mutations of TP53 confer novel functions not found in wild-type p53 and contribute to tumor development and progression. We report on the ge…

Cancer in a dish: progress using stem cells as a platform for cancer research. Open

Mo Liu, Jian Tu, Julian A. Gingold, Celine Shuet Lin Kong, Dung‐Fang Lee · 2018

Cancer models derived from patient specimens poorly reflect early-stage cancer development because cancer cells acquire numerous additional molecular alterations before the disease is clinically detectable. Earlier studies have used differ…

Li–Fraumeni Syndrome Disease Model: A Platform to Develop Precision Cancer Therapy Targeting Oncogenic p53 Open

Ruoji Zhou, An Xu, Julian A. Gingold, Louise C. Strong, Ruiying Zhao , et al. · 2017

Osteosarcoma: Molecular Pathogenesis and iPSC Modeling Open

Yu-Hsuan Lin, Brittany E. Jewell, Julian A. Gingold, Linchao Lu, Ruiying Zhao , et al. · 2017

The histogenesis of Ewing Sarcoma Open

Jian Tu, Zijun Huo, Julian A. Gingold, Ruiying Zhao, Jingnan Shen , et al. · 2017

Hatching status before embryo transfer is not correlated with implantation rate in chromosomally screened blastocysts Open

J. Rodriguez-Purata, Julian A. Gingold, Joseph Lee, M.C. Whitehouse, Richard E. Slifkin , et al. · 2016

JG is funded by MSTP grant T32 GM007280 (NIH). No additional funding was received. There are no conflicts of interest to declare..

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