Julian Bechold
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View article: Polyoxazolines with a Vicinally Double-Bioactivated Terminus for Biomacromolecular Affinity Assessment
Polyoxazolines with a Vicinally Double-Bioactivated Terminus for Biomacromolecular Affinity Assessment Open
Interactions between proteins and carbohydrates with larger biomacromolecules, e.g., lectins, are usually examined using self-assembled monolayers on target gold surfaces as a simplified model measuring setup. However, most of those measur…
View article: Cover Feature: Tuning the Product Spectrum of a Glycoside Hydrolase Enzyme by a Combination of Site‐Directed Mutagenesis and Tyrosine‐Specific Chemical Modification (Chem. Eur. J. 26/2019)
Cover Feature: Tuning the Product Spectrum of a Glycoside Hydrolase Enzyme by a Combination of Site‐Directed Mutagenesis and Tyrosine‐Specific Chemical Modification (Chem. Eur. J. 26/2019) Open
Selective chemical modification of proteins is a powerful tool for the rational design of enzymes. This work shows a combination of genetic and chemical engineering of a biocatalyst by conducting a tyrosine-specific modification at introdu…
View article: Exploring the Structural Space of the Galectin‐1–Ligand Interaction
Exploring the Structural Space of the Galectin‐1–Ligand Interaction Open
Galectin‐1 is a tumor‐associated protein recognizing the Galβ1‐4GlcNAc motif of cell‐surface glycoconjugates. Herein, we report the stepwise expansion of a multifunctional natural scaffold based on N ‐acetyllactosamine (Lac N Ac). We obtai…