Julian Blanke
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View article: A Systematic Evaluation of Machine Learning–Based Biomarkers for Major Depressive Disorder
A Systematic Evaluation of Machine Learning–Based Biomarkers for Major Depressive Disorder Open
Importance Biological psychiatry aims to understand mental disorders in terms of altered neurobiological pathways. However, for one of the most prevalent and disabling mental disorders, major depressive disorder (MDD), no informative bioma…
View article: A Systematic Evaluation of Machine Learning-based Biomarkers for Major Depressive Disorder across Modalities
A Systematic Evaluation of Machine Learning-based Biomarkers for Major Depressive Disorder across Modalities Open
Background Biological psychiatry aims to understand mental disorders in terms of altered neurobiological pathways. However, for one of the most prevalent and disabling mental disorders, Major Depressive Disorder (MDD), patients only margin…
View article: Towards a network control theory of electroconvulsive therapy response
Towards a network control theory of electroconvulsive therapy response Open
Electroconvulsive Therapy (ECT) is arguably the most effective intervention for treatment-resistant depression. While large interindividual variability exists, a theory capable of explaining individual response to ECT remains elusive. To a…
View article: Quantifying Deviations of Brain Structure and Function in Major Depressive Disorder Across Neuroimaging Modalities
Quantifying Deviations of Brain Structure and Function in Major Depressive Disorder Across Neuroimaging Modalities Open
Results of this case-control study suggest that even for maximum univariate biological differences, deviations between patients with MDD and healthy controls were remarkably small, single-participant prediction was not possible, and simila…
View article: More Alike than Different: Quantifying Deviations of Brain Structure and Function in Major Depressive Disorder across Neuroimaging Modalities
More Alike than Different: Quantifying Deviations of Brain Structure and Function in Major Depressive Disorder across Neuroimaging Modalities Open
Introduction: Identifying neurobiological differences between patients suffering from Major Depressive Disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for decades. However, recent meta- and mega-analyses…
View article: Towards a Network Control Theory of Electroconvulsive Therapy Response
Towards a Network Control Theory of Electroconvulsive Therapy Response Open
Electroconvulsive Therapy (ECT) is arguably the most effective intervention for treatment-resistant depression. While large interindividual variability exists, a theory capable of predicting individual response to ECT remains elusive. To a…
View article: Genetic, Individual, and Familial Risk Correlates of Brain Network Controllability in Major Depressive Disorder
Genetic, Individual, and Familial Risk Correlates of Brain Network Controllability in Major Depressive Disorder Open
Background: A therapeutic intervention in psychiatry can be viewed as an attempt to influence the brain's large-scale, dynamic network state transitions underlying cognition and behavior. Building on connectome-based graph analysis and con…