Julian Dewantiningrum
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View article: Placental Micro- and Nanoplastic Contamination: A Systematic Review of Eco-Exposome Pathways to Preterm Birth and Neonatal Outcomes
Placental Micro- and Nanoplastic Contamination: A Systematic Review of Eco-Exposome Pathways to Preterm Birth and Neonatal Outcomes Open
Objective: To systematically review emerging evidence on micro- and nanoplastic (MNP) contamination of the human placenta, explore molecular pathways underlying placental dysfunction, and evaluate associations with preterm birth and neonat…
View article: Perinatal exposure to ultraprocessed foods and its impact on maternal gut dysbiosis, placental inflammation, and neonatal immune programming: A systematic review
Perinatal exposure to ultraprocessed foods and its impact on maternal gut dysbiosis, placental inflammation, and neonatal immune programming: A systematic review Open
HIGHLIGHTS Perinatal ultraprocessed food (UPF) exposure disrupts maternal gut microbiota composition, increasing pro‑inflammatory taxa and systemic endotoxemia. Placental immune activation and oxidative stress represent key mediators linki…
View article: Reinterpreting potential biomarker in umbilical cord as a marker of chorioamnionitis and funisitis in prelabor ROM
Reinterpreting potential biomarker in umbilical cord as a marker of chorioamnionitis and funisitis in prelabor ROM Open
HIGHLIGHTS HsCRP and IL-6 levels in umbilical cord blood serve as reliable early biomarkers of chorioamnionitis and funisitis in prelabor ROM, enabling more accurate neonatal sepsis risk assessment and targeted clinical intervention. Early…
View article: Revisiting KANET in the context of fetal connectomics: defining optimal gestational windows for neurodevelopmental screening
Revisiting KANET in the context of fetal connectomics: defining optimal gestational windows for neurodevelopmental screening Open
Objectives To introduce the KANET-connectome matrix (KANET-Con) as a conceptual framework linking fetal behaviors observed on four-dimensional (4D) ultrasound to underlying neural network maturation, and to evaluate optimal gestational tim…
View article: Integrating mental health into obstetric practice: a review of collaborative care models for perinatal anxiety
Integrating mental health into obstetric practice: a review of collaborative care models for perinatal anxiety Open
Objective Perinatal anxiety is one of the most common yet least systematically addressed complications of preg- nancy and childbirth. Despite abundant evidence that collaborative and integrated care models improve maternal outcomes, obstet…
View article: Cadmium Exposure and Preeclampsia: A Systematic Review of Environmental Risk in Pregnancy
Cadmium Exposure and Preeclampsia: A Systematic Review of Environmental Risk in Pregnancy Open
Objective: To systematically evaluate current scientific evidence on the association between cadmium (Cd) exposure and the risk of preeclampsia in pregnant women, and to explore underlying mechanisms and population-specific patterns.Method…
View article: The fetal exposome and Preterm Birth: a systematic synthesis of environmental exposures and multi-omics evidence
The fetal exposome and Preterm Birth: a systematic synthesis of environmental exposures and multi-omics evidence Open
Objectives Preterm birth (PTB), defined as delivery before 37 weeks of gestation, is a leading cause of neonatal mortality and long-term developmental impairment. Its complex etiology, spanning environmental, genetic, psychosocial, and soc…
View article: The Indonesia pre‐eclampsia study ( <scp>INAPRES</scp> ): Pregnancy outcomes in pregnancy with pre‐eclampsia in Indonesia
The Indonesia pre‐eclampsia study ( <span>INAPRES</span> ): Pregnancy outcomes in pregnancy with pre‐eclampsia in Indonesia Open
Objective This study aimed to investigate maternal and neonatal outcomes of pregnancies complicated by pre‐eclampsia (PE) in Indonesia and analyze regional variations in risk factors and clinical outcomes across the country. Methods A mult…
View article: Artificial wombs in perinatal medicine: a transformative frontier in neonatal care and bioethics
Artificial wombs in perinatal medicine: a transformative frontier in neonatal care and bioethics Open
Objectives To evaluate the current state and translational readiness of artificial womb technology (AWT), focusing on its technical feasibility, preclinical validation, and ethical, legal, and clinical implications for perinatal medicine. …
View article: Virtual fetal holography for parental counseling and education: applications, limitations, and future directions
Virtual fetal holography for parental counseling and education: applications, limitations, and future directions Open
Introduction Effective prenatal counseling relies on clear communication of fetal development and potential complications. Conventional 2D and 3D ultrasound images often fail to intuitively convey complex anatomy to expectant parents, limi…
View article: Immunoediting in pregnancy: a new paradigm for understanding fetal tolerance and obstetric disease
Immunoediting in pregnancy: a new paradigm for understanding fetal tolerance and obstetric disease Open
Introduction Pregnancy poses an immunological paradox: the maternal immune system must tolerate a semi-allogeneic fetus while maintaining defense against infections. Rather than being an immunosuppressed state, gestation is now recognized …
View article: Plant-based antioxidant strategies with potential for preeclampsia prevention: clinical and mechanistic insights
Plant-based antioxidant strategies with potential for preeclampsia prevention: clinical and mechanistic insights Open
Background Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality, driven by oxidative stress, endothelial dysfunction, and systemic inflammation. Current preventive strategies, such as low-dose aspirin, offer mo…
View article: Endocrine disrupting chemicals: translating mechanisms into perinatal risk assessment
Endocrine disrupting chemicals: translating mechanisms into perinatal risk assessment Open
Objectives To evaluate the evidence linking prenatal exposure to environmental endocrine-disrupting chemicals (EDCs) – including bisphenol A (BPA), phthalates, and per- and polyfluoroalkyl substances (PFAS) – with adverse pregnancy and fet…
View article: 8K Fetal Ultrasound Imaging: Why So Skeptical? A Critical Evaluation of Clinical, Ethical, and Diagnostic Limits
8K Fetal Ultrasound Imaging: Why So Skeptical? A Critical Evaluation of Clinical, Ethical, and Diagnostic Limits Open
View article: Artificial Intelligence-based Characterization of Fetal Facial Motor Activity Patterns Using 4D Ultrasound Imaging
Artificial Intelligence-based Characterization of Fetal Facial Motor Activity Patterns Using 4D Ultrasound Imaging Open
View article: Nutriepigenomics in perinatal medicine: maternal nutrition as a modulator of fetal gene expression and long-term health
Nutriepigenomics in perinatal medicine: maternal nutrition as a modulator of fetal gene expression and long-term health Open
Introduction Maternal nutrition during pregnancy can influence fetal development through epigenetic modifications, affecting gene expression without altering DNA sequence. Nutriepigenomics – the study of nutrient-driven epigenetic regulati…
View article: Paternal mental health in the perinatal period: Uncovering the silent struggle and reframing family-centred care
Paternal mental health in the perinatal period: Uncovering the silent struggle and reframing family-centred care Open
Paternal mental health during the perinatal period remains under-recognised despite growing evidence of its impact on child development, partner well-being and family functioning. Although maternal mental health has become central to perin…
View article: Amniotic Fluid Embolism: a comprehensive review of diagnosis and management
Amniotic Fluid Embolism: a comprehensive review of diagnosis and management Open
Introduction Amniotic Fluid Embolism (AFE) is a rare but catastrophic obstetric emergency characterized by the sudden entry of amniotic fluid or fetal debris into the maternal circulation. This triggers acute cardiopulmonary collapse, diss…
View article: From exencephaly to anencephaly: a catastrophic continuum of neural tube defects from embryogenesis to ultrasonographic diagnosis
From exencephaly to anencephaly: a catastrophic continuum of neural tube defects from embryogenesis to ultrasonographic diagnosis Open
Introduction Neural tube defects (NTDs) are severe congenital anomalies arising from incomplete closure of the neural tube during early embryogenesis. Among cranial NTDs, exencephaly, acrania, and anencephaly represent a progressive develo…
View article: Blood Cadmium and Preterm Birth: A Systems Toxicology Review of Molecular Mechanisms, Placental Disruption, and Translational Obstetric Implications
Blood Cadmium and Preterm Birth: A Systems Toxicology Review of Molecular Mechanisms, Placental Disruption, and Translational Obstetric Implications Open
Objectives: Preterm birth (PTB) remains a leading global cause of neonatal morbidity and mortality, with multifactorial origins including inflammation, endocrine disruption, and placental dysfunction. Recent evidence identifies cadmium (Cd…
View article: Fetal neurobehavior and consciousness: a systematic review of 4D ultrasound evidence and ethical challenges
Fetal neurobehavior and consciousness: a systematic review of 4D ultrasound evidence and ethical challenges Open
Introduction Recent advancements in four-dimensional (4D) ultrasonography have enabled detailed observation of fetal behavior in utero , including facial movements, limb gestures, and stimulus responses. These developments have prompted re…
View article: Integrating KANET and Doppler indices to predict neurodevelopmental delays in high-risk pregnancies
Integrating KANET and Doppler indices to predict neurodevelopmental delays in high-risk pregnancies Open
Objectives To assess the predictive value of combining the Kurjak Antenatal Neurodevelopmental Test (KANET) with Doppler indices for early detection of neurodevelopmental delays in pregnancies of varying risk levels. Methods A prospective …
View article: Insights into Noninvasive Prenatal Testing Performance: A 4365-sample Analysis of Diagnostic and Quality Control Outcomes
Insights into Noninvasive Prenatal Testing Performance: A 4365-sample Analysis of Diagnostic and Quality Control Outcomes Open
Background: Noninvasive prenatal testing (NIPT) is a transformative tool in prenatal care, offering early detection of chromosomal abnormalities with high accuracy. Despite its widespread adoption, comprehensive analyses of diagnostic outc…
View article: Next-generation Maternal Immunisation for Group B Streptococcus, Cytomegalovirus and Emerging Pathogens: A Systematic Review, Meta-analysis and Translational Roadmap
Next-generation Maternal Immunisation for Group B Streptococcus, Cytomegalovirus and Emerging Pathogens: A Systematic Review, Meta-analysis and Translational Roadmap Open
Group B Streptococcus (GBS) and cytomegalovirus (CMV) remain major causes of stillbirth, neonatal sepsis, congenital infection, and lifelong neurodevelopmental impairment, yet no licensed maternal vaccines exist. Recent advances in conjuga…
View article: Fetal Neuroassessment and Intrauterine Inflammation: Emerging Perspectives for Term Pregnancies
Fetal Neuroassessment and Intrauterine Inflammation: Emerging Perspectives for Term Pregnancies Open
Subclinical maternal immune activation (MIA) is increasingly recognized as a potential contributor to long-term neurodevelopmental disorders even in pregnancies that reach full term without overt clinical complications. These inflammatory …
View article: Ferroptosis and apoptosis crosstalk in early-onset preeclampsia: redefining placental cell death and maternal survival pathways
Ferroptosis and apoptosis crosstalk in early-onset preeclampsia: redefining placental cell death and maternal survival pathways Open
Early-onset preeclampsia (EOPE), which occurs before 34 weeks of gestation, remains a major cause of maternal and perinatal illness and death worldwide. Traditionally, placental dysfunction in EOPE has been linked to dysregulated apoptosis…
View article: Microplastics in the Perinatal Period: Emerging Evidence on Maternal Exposure, Placental Transfer, and Fetal Health Outcomes
Microplastics in the Perinatal Period: Emerging Evidence on Maternal Exposure, Placental Transfer, and Fetal Health Outcomes Open
Microplastic pollution has emerged as a pervasive environmental and biomedical concern, with particles < 5 mm identified in drinking water, air, food, and human tissues. Recent studies have detected microplastics in maternal blood, placent…
View article: Placental Senescence In utero: Molecular Markers, Imaging Correlates, and the Next Frontier in Perinatal Risk Stratification
Placental Senescence In utero: Molecular Markers, Imaging Correlates, and the Next Frontier in Perinatal Risk Stratification Open
Despite advances in prenatal care, conditions such as late stillbirth, intrauterine growth restriction, and pre-eclampsia continue to defy early detection, often occurring in pregnancies previously considered low risk. Emerging evidence su…
View article: KANET at the Crossroads of Clinical Practice and Fetal Neuroscience: A Review of Two Decades
KANET at the Crossroads of Clinical Practice and Fetal Neuroscience: A Review of Two Decades Open
View article: Placenta Accreta Spectrum and Cesarean Trends: Global Insights with Focus on Indonesia
Placenta Accreta Spectrum and Cesarean Trends: Global Insights with Focus on Indonesia Open