Julian Leberzammer
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View article: Galectin-1 induces macrophage immunometabolic reprogramming, modulates T cell immunity and attenuates atherosclerotic plaque formation.
Galectin-1 induces macrophage immunometabolic reprogramming, modulates T cell immunity and attenuates atherosclerotic plaque formation. Open
Background And Aims Atherosclerosis is a chronic immunometabolic disease driven by lipid accumulation and immune cell infiltration. Macrophages and T cells play key roles throughout plaque development. Galectin-1 (Gal-1), a glycan-binding …
View article: Chemokines, molecular drivers of thromboinflammation and immunothrombosis
Chemokines, molecular drivers of thromboinflammation and immunothrombosis Open
Blood clotting is a finely regulated process that is essential for hemostasis. However, when dysregulated or spontaneous, it promotes thrombotic disorders. The fact that these are triggered, accompanied and amplified by inflammation is ref…
View article: Targeting platelet-derived CXCL12 impedes arterial thrombosis
Targeting platelet-derived CXCL12 impedes arterial thrombosis Open
The prevention and treatment of arterial thrombosis continue to be clinically challenging, and understanding the relevant molecular mechanisms in detail may facilitate the quest to identify novel targets and therapeutic approaches that imp…
View article: Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation
Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation Open
Functional synergism and inhibitory effects of chemokine heterodimers can be selectively targeted by specific peptides in models of inflammation.