Julian Malicki
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View article: Can Advances in Artificial Intelligence Strengthen the Role of Intraoperative Radiotherapy in the Treatment of Cancer?
Can Advances in Artificial Intelligence Strengthen the Role of Intraoperative Radiotherapy in the Treatment of Cancer? Open
Intraoperative radiotherapy (IORT) is a radiation technique that allows for the delivery of a high radiation dose to the target while preserving the surrounding structures, which can be displaced during the surgical procedure. An important…
View article: Can Advances in Artificial Intelligence Strengthen the Role of Intraoperative Radiotherapy in the Treatment of Cancer?
Can Advances in Artificial Intelligence Strengthen the Role of Intraoperative Radiotherapy in the Treatment of Cancer? Open
Introduction. Intraoperative radiotherapy (IORT) is now widely used in clinical practice. This review aims to report the most relevant clinical data and how the rise of the com-putation capacity can impact the development of IORT. Methods.…
View article: Nucleus Accumbens Associated Protein 1 in Cancers—The Real Value
Nucleus Accumbens Associated Protein 1 in Cancers—The Real Value Open
Malignant tumors are a leading cause of death worldwide, second only to cardiovascular disease. They occur in every population and have a high risk of mortality. The etiopathogenesis of malignant tumors is diverse and there are still many …
View article: Monte Carlo methods to assess biological response to radiation in peripheral organs and in critical organs near the target
Monte Carlo methods to assess biological response to radiation in peripheral organs and in critical organs near the target Open
It has long been assumed that radiation doses to peripheral organs located far from the target volume are too low to have any clinical impact. In recent years, however, concerns about the risk of treatment-induced secondary cancers, even i…
View article: Heterogeneity in biological response of MDA-MB-231 cells after proton irradiation along different parts of the depth-dose curve: before, within, and behind the Bragg peak
Heterogeneity in biological response of MDA-MB-231 cells after proton irradiation along different parts of the depth-dose curve: before, within, and behind the Bragg peak Open
These findings suggest that despite administering a consistent proton dose to the target area, there can be a range of different biological reactions, which might have significant indications for clinical procedures.
View article: Impact of Proton Irradiation Depending on Breast Cancer Subtype in Patient-Derived Cell Lines
Impact of Proton Irradiation Depending on Breast Cancer Subtype in Patient-Derived Cell Lines Open
Research on different types of ionizing radiation’s effects has been ongoing for years, revealing its efficacy in damaging cancer cells. Solid tumors comprise diverse cell types, each being able to respond differently to radiation. This st…
View article: Diagnostic Potential of miR-143-5p, miR-143-3p, miR-551b-5p, and miR-574-3p in Chemoresistance of Locally Advanced Gastric Cancer: A Preliminary Study
Diagnostic Potential of miR-143-5p, miR-143-3p, miR-551b-5p, and miR-574-3p in Chemoresistance of Locally Advanced Gastric Cancer: A Preliminary Study Open
Gastric cancer (GC) is one of the most frequently diagnosed cancers in the world. Although the incidence is decreasing in developed countries, the treatment results are still unsatisfactory. The standard treatment for locally advanced gast…
View article: Diagnostic Potential of miR-143-5p, miR-143-3p, miR-551b-5p and miR-574-3p in Chemoresistance of Locally Advanced Gastric Cancer: A Preliminary Study
Diagnostic Potential of miR-143-5p, miR-143-3p, miR-551b-5p and miR-574-3p in Chemoresistance of Locally Advanced Gastric Cancer: A Preliminary Study Open
Introduction: Gastric cancer (GC) is one of the most frequently diagnosed cancers in the world. Although the incidence is decreasing in developed countries, treatment results are still unsatisfactory. The standard treatment for locally adv…
View article: Lymphovascular Invasion in Gastric Cancer—Important or Unimportant?
Lymphovascular Invasion in Gastric Cancer—Important or Unimportant? Open
Introduction: Gastric cancer (GC) is one of the most common cancers in the world. It is a very aggressive and heterogeneous tumor. GC does not cause symptoms, so it is often diagnosed in an advanced stage and associated with poor prognosis…
View article: Navigating challenges: optimising methods for primary cell culture isolation
Navigating challenges: optimising methods for primary cell culture isolation Open
Primary cell lines are invaluable for exploring cancer biology and investigating novel treatments. Despite their numerous advantages, primary cultures are laborious to obtain and maintain in culture. Hence, established cell lines are still…
View article: IROCA-TES: Improving Quality in Radiation Oncology through Clinical Audits — Training and Education for Standardization
IROCA-TES: Improving Quality in Radiation Oncology through Clinical Audits — Training and Education for Standardization Open
BACKGROUND: Clinical audits are an important tool to objectively assess clinical protocols, procedures, and processes and to detect deviations from good clinical practice. The main aim of this project is to determine adherence to a core se…
View article: Primary cancer-associated fibroblasts exhibit high heterogeneity among breast cancer subtypes
Primary cancer-associated fibroblasts exhibit high heterogeneity among breast cancer subtypes Open
According to our findings, there was no significant pattern in the classification of cancer-associated fibroblasts. The results of biomarkers expression were heterogeneous, thus no specific subtypes were identified. Furthermore, a comparis…
View article: Value of [18F]FDG PET/CT radiomic parameters in the context of response to chemotherapy in advanced cervical cancer
Value of [18F]FDG PET/CT radiomic parameters in the context of response to chemotherapy in advanced cervical cancer Open
The first-order statistical (FOS) and second-order texture analysis on basis of Gray-Level Co-occurence Matrix (GLCM) were obtained to assess metabolic, volumetric, statistical and radiomic parameters of cervical cancer in response to chem…
View article: Radiotherapy planning in a prostate cancer phantom model with intraprostatic dominant lesions using stereotactic body radiotherapy with volumetric modulated arcs and a simultaneous integrated boost
Radiotherapy planning in a prostate cancer phantom model with intraprostatic dominant lesions using stereotactic body radiotherapy with volumetric modulated arcs and a simultaneous integrated boost Open
Aim In the treatment of prostate cancer with radiation therapy, the addition of a simultaneous integrated boost (SIB) to the dominant intraprostatic lesions (DIL) may improve local control. In this study, we aimed to determine the optimal …
View article: Management of Onsite and Remote Communication in Oncology Hospitals: Data Protection in an Era of Rapid Technological Advances
Management of Onsite and Remote Communication in Oncology Hospitals: Data Protection in an Era of Rapid Technological Advances Open
Modern communication and information technologies are rapidly being deployed at health care institutions around the world. Although these technologies offer many benefits, ensuring data protection is a major concern, and implementation of …
View article: Optimisation of methods for isolation of primary cancer cells from breast cancer tumour
Optimisation of methods for isolation of primary cancer cells from breast cancer tumour Open
Primary cell lines are an invaluable tool to explore cancer biology and molecular processes and investigate novel treatments. Despite their numerous advantages, primary cultures are laborious to obtain and maintain in culture thus rarely u…
View article: Are we ready to change treatment planning for left-side breast cancer radiotherapy?
Are we ready to change treatment planning for left-side breast cancer radiotherapy? Open
View article: Role of Interleukins and New Perspectives in Mechanisms of Resistance to Chemotherapy in Gastric Cancer
Role of Interleukins and New Perspectives in Mechanisms of Resistance to Chemotherapy in Gastric Cancer Open
Gastric cancer (GC) is the fourth most common cancer in the world in terms of incidence and second in terms of mortality. Chemotherapy is the main treatment for GC. The greatest challenge and major cause of GC treatment failure is resistan…
View article: Treatment-integrated imaging, radiomics, and personalised radiotherapy: the future is at hand
Treatment-integrated imaging, radiomics, and personalised radiotherapy: the future is at hand Open
Since the introduction of computed tomography for planning purposes in the 1970s, we have been observing a continuous development of different imaging methods in radiotherapy. The current achievements of imaging technologies in radiotherap…
View article: Nontarget and Out-of-Field Doses from Electron Beam Radiotherapy
Nontarget and Out-of-Field Doses from Electron Beam Radiotherapy Open
In clinical radiotherapy, the most important aspects are the dose distribution in the target volume and healthy organs, including out-of-field doses in the body. Compared to photon beam radiation, dose distribution in electron beam radioth…
View article: Cellular Damage in the Target and Out-Of-Field Peripheral Organs during VMAT SBRT Prostate Radiotherapy: An In Vitro Phantom-Based Study
Cellular Damage in the Target and Out-Of-Field Peripheral Organs during VMAT SBRT Prostate Radiotherapy: An In Vitro Phantom-Based Study Open
Hypo-fractionated stereotactic body radiation therapy (SBRT) is an effective treatment for prostate cancer (PCa). Although many studies have investigated the effects of SBRT on the prostate and adjacent organs, little is known about the ef…
View article: FLASH radiotherapy: an emerging approach in radiation therapy
FLASH radiotherapy: an emerging approach in radiation therapy Open
FLASH radiotherapy (RT) is a technique involving the delivery of ultra-high dose rate radiation to the target. FLASH-RT has been shown to reduce radiation-induced toxicity in healthy tissues without compromising the anti-cancer effects of …
View article: Criteria for Verification and Replanning Based on the Adaptive Radiotherapy Protocol “Best for Adaptive Radiotherapy” in Head and Neck Cancer
Criteria for Verification and Replanning Based on the Adaptive Radiotherapy Protocol “Best for Adaptive Radiotherapy” in Head and Neck Cancer Open
No clear criteria have yet been established to guide decision-making for patient selection and the optimal timing of adaptive radiotherapy (ART) based on image-guided radiotherapy (IGRT). We have developed a novel protocol—the Best for Ada…
View article: Evaluation and risk factors of volume and dose differences of selected structures in patients with head and neck cancer treated on Helical TomoTherapy by using Deformable Image Registration tool
Evaluation and risk factors of volume and dose differences of selected structures in patients with head and neck cancer treated on Helical TomoTherapy by using Deformable Image Registration tool Open
Introduction: The aim of this study was the evaluation of volume and dose differences in selected structures in patients with head and neck cancer during treatment on Helical TomoTherapy (HT) using a commercially available deformable image…
View article: Influence of Specific Treatment Parameters on Nontarget and Out-of-Field Doses in a Phantom Model of Prostate SBRT with CyberKnife and TrueBeam
Influence of Specific Treatment Parameters on Nontarget and Out-of-Field Doses in a Phantom Model of Prostate SBRT with CyberKnife and TrueBeam Open
The aim of the study was to determine the influence of a key treatment plan and beam parameters on overall dose distribution and on doses in organs laying in further distance from the target during prostate SBRT. Multiple representative tr…
View article: Thermal Boost to Breast Tumor Bed—New Technique Description, Treatment Application and Example Clinical Results
Thermal Boost to Breast Tumor Bed—New Technique Description, Treatment Application and Example Clinical Results Open
(1) Current breast-conserving therapy for breast cancer consists of a combination of many consecutive treatment modalities. The most crucial goal of postoperative treatment is to eradicate potentially relapse-forming residual cancerous cel…
View article: Radiation Oncology in a Humanitarian Emergency: Experience with Ukrainian Refugees at 2 Cancer Centers in Poland and Italy
Radiation Oncology in a Humanitarian Emergency: Experience with Ukrainian Refugees at 2 Cancer Centers in Poland and Italy Open
View article: Does CyberKnife improve dose distribution versus IMRT and VMAT on a linear accelerator in low-risk prostate cancer?
Does CyberKnife improve dose distribution versus IMRT and VMAT on a linear accelerator in low-risk prostate cancer? Open
Background Hypofractionated stereotactic body radiation therapy (SBRT) for prostate cancer (PCa) can be delivered with the robot-assisted CyberKnife (CK) system or on a linear accelerator using dynamic intensity-modulated radiotherapy (IMR…
View article: Dosimetric Comparison of Ultra-Hypofractionated and Conventionally Fractionated Radiation Therapy Boosts for Patients with High-Risk Prostate Cancer
Dosimetric Comparison of Ultra-Hypofractionated and Conventionally Fractionated Radiation Therapy Boosts for Patients with High-Risk Prostate Cancer Open
Recent comparison of an ultra-hypofractionated radiotherapy (UF-RT) boost to a conventionally fractionated (CF-RT) option showed similar toxicity and disease control outcomes. An analysis of the treatment plans for these patients is needed…
View article: Development of a quasi‐humanoid phantom to perform dosimetric and radiobiological measurements for out‐of‐field doses from external beam radiation therapy
Development of a quasi‐humanoid phantom to perform dosimetric and radiobiological measurements for out‐of‐field doses from external beam radiation therapy Open
Our understanding of low dose, out‐of‐field radiation and their radiobiological effects are limited, in part due to the rapid technological advances in external beam radiotherapy, especially for non‐coplanar and dynamic techniques. Reliabl…