Explanipedia

103 Functional spatial mapping of the tumour immune microenvironment in advanced melanoma patients Open

Emma Wagner, Samuel R.W. Legg, Yichen Zhang, Chris Applebee, Allison Betof Warner , et al. · 2025

AXL tyrosine kinase inhibition rescues immune checkpoint blockade-resistant melanoma in a tumor microenvironment-dependent fashion Open

Amanda Kirane, David Lee, Saurabh Sharma, Elena Safrygina, Christopher J. Applebee , et al. · 2025

Melanomas resistant to immune checkpoint blockade (ICB) therapies are frequently characterized by having a tumor-immune microenvironment (TiME) enriched with immunosuppressive tumor associated macrophages (TAMs). AXL tyrosine kinase is an …

A probabilistic forecasting framework for neighbourhood-level disaggregation of electric vehicle adoption scenarios Open

Isaac Flower, Furong Li, Julián Padget · 2025

The rapid growth of electric vehicle (EV) adoption presents significant challenges for electricity networks, particularly at the low-voltage level, where clustered neighbourhood demand risks overloading infrastructure. Existing scenario-ba…

Functional Spatial Mapping of the Tumour Immune Microenvironment In Advanced Melanoma Patients Open

Samuel R.W. Legg, Emma Wagner, Christopher J. Applebee, Amanda Kirane, Julián Padget , et al. · 2025

Precision medicine is the gold standard we strive to achieve to tailor therapy to individual patients, maximising effect while minimising toxicities. Many methodologies have improved the quality of biomarker research toward this aim; howev…

AXL-GAS6/PROS1 Interaction: A Critical Switch Between Aberrant- and Healthy Repair Following Alveolar Lung Injury Open

Devona Soetopo, Christoph H. Mayr, Katrin Fundel‐Clemens, Fidel Ramírez, Coralie Viollet , et al. · 2025

Previous studies have shown that altered AXL signaling is implicated in various diseases, with GAS6 recognized as its only relevant ligand to date. In this study, we show for the first-time a direct interaction between AXL and PROS1 using …

Operationalising AIS Bias Management Open

Rahaf Albalkhi, Jussi Leppälä, Julián Padget · 2025

Do we need a data sharing infrastructure for the energy sector? Open

Furong Li, Nigel Turvey, Lewis Dale, James G. Scott, Julián Padget , et al. · 2024

Diversifying and decarbonising energy production by investing in renewables and clean energy is the UK Government's blueprint to power Britain from Britain. Technological developments and deployment are progressing rapidly, however, the wh…

Open data for modelling the impacts of electric vehicles on UK distribution networks: Opportunities for a digital spine Open

Isaac Flower, Furong Li, Julián Padget · 2024

This paper provides a detailed overview of the current snapshot of available open data for modelling the impacts of electric vehicles (EVs) on the UK distribution network, highlighting opportunities for a digital spine. We are the first to…

Correction: Spatial functional mapping of hypoxia inducible factor heterodimerisation and immune checkpoint regulators in clear cell renal cell carcinoma Open

Elena Safrygina, Christopher J. Applebee, Alan McIntyre, Julián Padget, Banafshé Larijani · 2024

Spatial functional mapping of hypoxia inducible factor heterodimerisation and immune checkpoint regulators in clear cell renal cell carcinoma Open

Elena Safrygina, Christopher J. Applebee, Alan McIntyre, Julián Padget, Banafshé Larijani · 2024

Understanding the Vulnerability of CLIP to Image Compression Open

Cangxiong Chen, Vinay P. Namboodiri, Julián Padget · 2023

CLIP is a widely used foundational vision-language model that is used for zero-shot image recognition and other image-text alignment tasks. We demonstrate that CLIP is vulnerable to change in image quality under compression. This surprisin…

Spatial Functional Mapping of Hypoxia Inducible Factor Heterodimerisation and Immune checkpoint regulators in clear cell Renal Cell Carcinoma Open

Elena Safrygina, Christopher J. Applebee, Alan McIntyre, Julián Padget, Banafshé Larijani · 2023

Background: Clear cell renal cell carcinoma (ccRCC) is a highly malignant subtype of kidney cancer. 90% of ccRCC have inactivating mutations of VHL that stablise transcription factors, HIF1α and HIF2α, only stabilised in hypoxia. The varie…

Addressing the Value Alignment Problem Through Online Institutions Open

Pablo Noriega, Harko Verhagen, Julián Padget, Mark d’Inverno · 2023

Governing Agents on the Web Open

Victor Charpenay, Matteo Baldoni, Andrei Ciortea, Stephen Cranefield, Julián Padget , et al. · 2023

Governance of Autonomous Agents on the Web: Challenges and Opportunities Open

Timotheus Kampik, Adnane Mansour, Olivier Boissier, Sabrina Kirrane, Julián Padget , et al. · 2022

The study of autonomous agents has a long tradition in the Multiagent Systems and the Semantic Web communities, with applications ranging from automating business processes to personal assistants. More recently, the Web of Things (WoT), wh…

Governance of Autonomous Agents on the Web: Challenges and Opportunities Open

Timotheus Kampik, Adnane Mansour, Olivier Boissier, Sabrina Kirrane, Julián Padget , et al. · 2022

The study of autonomous agents has a long history in the Multiagent System and the Semantic Web communities, with applications ranging from automating business processes to personal assistants. More recently, the Web of Things (WoT), which…

Trusting the trust machine: Evaluating trust signals of blockchain applications Open

Fabiane Völter, Nils Urbach, Julián Padget · 2021

A Norm Emergence Framework for Normative MAS – Position Paper Open

Andreasa Morris-Martin, Marina De Vos, Julián Padget · 2021

Towards a Goal-oriented Agent-based Simulation framework for High-Performance Computing Open

Dmitry Gnatyshak, Luis Oliva-Felipe, Sergio Álvarez-Napagao, Julián Padget, Javier Vázquez-Salceda , et al. · 2019

Currently, agent-based simulation frameworks force the user to choose between simulations involving a large number of agents (at the expense of limited agent reasoning capability) or simulations including agents with increased reasoning ca…

Norm emergence in multiagent systems: a viewpoint paper Open

Andreasa Morris-Martin, Marina De Vos, Julián Padget · 2019

Norms are utilised in agent societies to encourage acceptable behaviour by the participating agents. They can be established or revised from the top-down (authority) or from the bottom-up (populace). The study of norm creation from the bot…

Argumentation-Based Reasoning about Plans, Maintenance Goals, and Norms Open

Zohreh Shams, Marina De Vos, Nir Oren, Julián Padget · 2019

In a normative environment, an agent’s actions are directed not only by its goals but also by the norms activated by its actions and those of other actors. The potential for conflict between agent goals and norms makes decision making chal…

Geobotanical expression of a blind kimberlite pipe, central India Open

John E. Carlson, Rebecca J. Johnson, May F. McCallum, Julián Padget · 2019

A teledetective study of kimberlite regions in N. America, E. Africa, and Siberia Open

John E. Carlson, Rebecca J. Johnson, May F. McCallum, Julián Padget · 2019

Evaluation of geophysical techniques for diatreme delineation in the Colorado Wyoming Kimberlite Province Open

John E. Carlson, Rebecca J. Johnson, M. E. McCallum, Julián Padget · 2019

Towards a Goal-Oriented Agent-Based Simulation Framework for High-Performance Computing Open

Dmitry Gnatyshak, Luis Felipe, Sergio Álvarez-Napagao, Julián Padget, Javier Vázquez-Salceda , et al. · 2019

Currently, agent-based simulation frameworks force the user to choose between simulations involving a large number of agents (at the expense of limited agent reasoning capability) or simulations including agents with increased reasoning ca…

Representing and reasoning about policy for agent-based simulation Open

Julián Padget · 2019

ENLITEN - A dataset and its associated analysis code for the paper entitled "Designing sensor sets for capturing energy events in buildings" Open

Jee Hang Lee, Elizabeth Gabe‐Thomas, Tom Lovett, Julián Padget, Sukumar Natarajan , et al. · 2018

This dataset contains data and software source code supporting the paper entitled 'Design sensor sets for capturing energy events in buildings'. It contains raw data from sets of domestic sensors measuring temperature, humidity, levels of …

Deontic Sensors Open

Julián Padget, Marina De Vos, Charlie Ann Page · 2018

Normative capabilities in multi-agent systems (MAS) can be represented within agents, separately as institutions, or a blend of the two. This paper addresses how to extend the principles of open MAS to the provision of normative reasoning …

Systemic approaches to incident analysis in aviation: Comparison of STAMP, agent-based modelling and institutions Open

Nataliya Mogles, Julián Padget, Tibor Bosse · 2018

Fine-Grained Access Control via Policy-Carrying Data Open

Julián Padget, Wamberto Vasconcelos · 2018

We address the problem of associating access policies with datasets and how to monitor compliance via policy-carrying data. Our contributions are a formal model in first-order logic inspired by normative multi-agent systems to regulate dat…

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