Julian R. Naglik
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View article: Eosinophil CD48 interactions with Candida albicans Als6 is protective in vitro and in mouse systemic candidiasis
Eosinophil CD48 interactions with Candida albicans Als6 is protective in vitro and in mouse systemic candidiasis Open
View article: Commensal colonization of <i>Candida albicans</i> in the mouse gastrointestinal tract is mediated via expression of candidalysin and adhesins
Commensal colonization of <i>Candida albicans</i> in the mouse gastrointestinal tract is mediated via expression of candidalysin and adhesins Open
The ubiquitous fungal pathogen Candida albicans has the potential to either asymptomatically colonize the gastrointestinal (GI) tract or become an invasive pathogen through mechanisms that remain incompletely understood. Here we explored t…
View article: Selective targeting of IL-1RAP-dependent eosinophilic inflammation in allergic fungal airway disease
Selective targeting of IL-1RAP-dependent eosinophilic inflammation in allergic fungal airway disease Open
It is estimated that in excess of 10 million people around the globe are affected by severe asthma and fungal sensitisation (SAFS) or allergic bronchopulmonary aspergillosis (ABPA), severe asthma endotypes driven by hypersensitivity to env…
View article: Early<i>Candida</i>–Oral Tumor Interactions Suggest miRNA-Mediated Regulation of Inflammatory and Tumor-associated processes
Early<i>Candida</i>–Oral Tumor Interactions Suggest miRNA-Mediated Regulation of Inflammatory and Tumor-associated processes Open
When simultaneously present, oral cancer and oral candidiasis are associated with high mortality. Recently, fungi-driven OSCC has emerged as a recognized phenomenon, that is triggered by Candida and sustained by several pro-tumor mechanism…
View article: The fungal peptide toxin candidalysin induces distinct membrane repair mechanisms compared to bacterial pore-forming toxins
The fungal peptide toxin candidalysin induces distinct membrane repair mechanisms compared to bacterial pore-forming toxins Open
The common fungal pathogen, Candida albicans , relies on the pore-forming toxin candidalysin to damage host cells. Cells counteract pore-forming toxins by Ca 2+ -dependent mechanisms, such as microvesicle shedding and annexin recruitment t…
View article: Candidalysin biology and activation of host cells
Candidalysin biology and activation of host cells Open
Candida albicans is an opportunistic fungal pathogen that can cause life-threatening systemic infections and distressing mucosal infections. A major breakthrough in understanding C. albicans pathogenicity was the discovery of candidalysin,…
View article: <i>Candida albicans</i> biofilm extracellular vesicles deliver candidalysin to epithelial cell membranes and induce host cell responses
<i>Candida albicans</i> biofilm extracellular vesicles deliver candidalysin to epithelial cell membranes and induce host cell responses Open
Extracellular vesicles (EVs) are heterogeneous particles encapsulated with a phospholipid bilayer membrane. EVs have evolved diverse biological functions, serving mainly as prominent mediators and regulators of cell-cell communication. Thi…
View article: EGR1 regulates oral epithelial cell responses to <i>Candida albicans</i> via the EGFR- ERK1/2 pathway
EGR1 regulates oral epithelial cell responses to <i>Candida albicans</i> via the EGFR- ERK1/2 pathway Open
Candida albicans is a fungal pathobiont colonizing mucosal surfaces of the human body, including the oral cavity. Under certain predisposing conditions, C. albicans invades mucosal tissues activating EGFR-MAPK signalling path…
View article: Variations in candidalysin amino acid sequence influence toxicity and host responses
Variations in candidalysin amino acid sequence influence toxicity and host responses Open
Candida albicans causes millions of mucosal infections in humans annually. Hyphal overgrowth on mucosal surfaces is frequently associated with tissue damage caused by candidalysin, a secreted peptide toxin that destabilizes the plasma memb…
View article: Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection
Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection Open
The opportunistic fungal pathogen Candida albicans thrives on human mucosal surfaces as a harmless commensal, but frequently causes infections under certain predisposing conditions. Translocation across the intestinal barrier into the bloo…
View article: Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences
Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences Open
The opportunistic fungal pathogen Candida albicans damages host cells via its peptide toxin, candidalysin. Before secretion, candidalysin is embedded in a precursor protein, Ece1, which consists of a signal peptide, the precursor of candid…
View article: Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis
Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis Open
Candida albicans can cause mucosal infections in humans. This includes oropharyngeal candidiasis, which is commonly observed in human immunodeficiency virus infected patients, and vulvovaginal candidiasis (VVC), which is the most frequent …
View article: Immunity to pathogenic mucosal C. albicans infections mediated by oral megakaryocytes activated by IL-17 and candidalysin
Immunity to pathogenic mucosal C. albicans infections mediated by oral megakaryocytes activated by IL-17 and candidalysin Open
The fungus Candida albicans can cause mucosal infections including oropharyngeal candidiasis (OPC) in immunocompromised patients. In humans, an increased risk of fungal infections correlates with thrombocytopenia. However, our understandin…
View article: P145 Phagocyte responses to gut-derived C. albicans are modified in inflammatory bowel disease
P145 Phagocyte responses to gut-derived C. albicans are modified in inflammatory bowel disease Open
Background Fungi are a key component of the human gut microbiota and have been strongly implicated in the pathogenesis of inflammatory bowel disease (IBD). Candida albicans typically exists as a commensal yeast within healthy hosts but can…
View article: <i>Candida albicans</i> induces neutrophil extracellular traps and leucotoxic hypercitrullination via candidalysin
<i>Candida albicans</i> induces neutrophil extracellular traps and leucotoxic hypercitrullination via candidalysin Open
The peptide toxin candidalysin, secreted by Candida albicans hyphae, promotes stimulation of neutrophil extracellular traps (NETs). However, candidalysin alone triggers a distinct mechanism for NET‐like structures (NLS), which are more com…
View article: Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis
Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis Open
The fungal pathogen Candida albicans is linked to chronic brain diseases such as Alzheimer's disease (AD), but the molecular basis of brain anti-Candida immunity remains unknown. We show that C. albicans enters the mouse brain from the blo…
View article: EGR1 regulates oral epithelial cell responses to<i>Candida albicans</i>via the EGFR- ERK1/2 pathway
EGR1 regulates oral epithelial cell responses to<i>Candida albicans</i>via the EGFR- ERK1/2 pathway Open
Candida albicans is a fungal pathobiont colonising mucosal surfaces of the human body, including the oral cavity. Under certain predisposing conditions, C. albicans invades mucosal tissues activating EGFR-MAPK signalling pathways in epithe…
View article: Aspergillus fumigatus Drives Tissue Damage via Iterative Assaults upon Mucosal Integrity and Immune Homeostasis
Aspergillus fumigatus Drives Tissue Damage via Iterative Assaults upon Mucosal Integrity and Immune Homeostasis Open
The human lung is constantly exposed to Aspergillus fumigatus spores, the most prevalent worldwide cause of fungal respiratory disease. Pulmonary tissue damage is a unifying feature of Aspergillus -related diseases; however, the mechanisti…
View article: Fungal infection drives metabolic reprogramming in epithelial cells via aerobic glycolysis and an alternative TCA cycle shunt
Fungal infection drives metabolic reprogramming in epithelial cells via aerobic glycolysis and an alternative TCA cycle shunt Open
Immunometabolic changes induced by the fungal pathobiont Candida albicans drive complex responses in innate immune cells. However, whether and how C. albicans causes remodelling of oral epithelial cell metabolism is unclear. Here, we use i…
View article: <i>Candida albicans</i> promotes neutrophil extracellular trap formation and leukotoxic hypercitrullination via the peptide toxin candidalysin
<i>Candida albicans</i> promotes neutrophil extracellular trap formation and leukotoxic hypercitrullination via the peptide toxin candidalysin Open
The cytolytic peptide toxin candidalysin is secreted by the invasive, hyphal form of the human fungal pathogen, Candida albicans . Candidalysin is essential for inducing host cell damage during mucosal and systemic C. albicans infections, …
View article: Receptor-kinase EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin
Receptor-kinase EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin Open
Candida albicans (C. albicans) is a dimorphic commensal human fungal pathogen that can cause severe oropharyngeal candidiasis (oral thrush) in susceptible hosts. During invasive infection, C. albicans hyphae invade oral epithelial cells (O…
View article: Author Correction: Immune regulation by fungal strain diversity in inflammatory bowel disease
Author Correction: Immune regulation by fungal strain diversity in inflammatory bowel disease Open
View article: The <i>Candida albicans</i> toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways
The <i>Candida albicans</i> toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways Open
The fungal pathogen Candida albicans secretes the peptide toxin candidalysin, which damages epithelial cells and drives an innate inflammatory response mediated by the epidermal growth factor receptor (EGFR) and mitogen-activated protein k…
View article: Immune regulation by fungal strain diversity in inflammatory bowel disease
Immune regulation by fungal strain diversity in inflammatory bowel disease Open
The fungal microbiota (mycobiota) is an integral part of the complex multikingdom microbial community colonizing the mammalian gastrointestinal tract and has an important role in immune regulation1-6. Although aberrant changes i…
View article: EGFR-MAPK adaptor proteins mediate the epithelial response to <i>Candida albicans</i> via the cytolytic peptide toxin, candidalysin
EGFR-MAPK adaptor proteins mediate the epithelial response to <i>Candida albicans</i> via the cytolytic peptide toxin, candidalysin Open
Candida albicans ( C. albicans ) is a dimorphic human fungal pathogen that can cause severe oropharyngeal candidiasis (OPC, oral thrush) in susceptible hosts. During invasive infection, C. albicans hyphae invade oral epithelial cells (OECs…
View article: Candidalysins Are a New Family of Cytolytic Fungal Peptide Toxins
Candidalysins Are a New Family of Cytolytic Fungal Peptide Toxins Open
Pathogenic fungi kill an estimated 1.5 million people every year. Recently, we discovered that the fungal pathogen Candida albicans secretes a peptide toxin called candidalysin during mucosal infection.
View article: Candida albicans Enhances the Progression of Oral Squamous Cell Carcinoma<i>In Vitro</i>and<i>In Vivo</i>
Candida albicans Enhances the Progression of Oral Squamous Cell Carcinoma<i>In Vitro</i>and<i>In Vivo</i> Open
Oral squamous cell carcinoma (OSCC) is a serious health issue worldwide that accounts for 2% to 4% of all cancer cases. Previous studies have revealed a higher yeast carriage and diversity in oral cancer patients than in healthy individual…
View article: Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion
Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion Open
Candida albicans is both a commensal and an opportunistic fungal pathogen. Invading hyphae of C. albicans secrete candidalysin, a pore-forming peptide toxin. To prevent cell death, epithelial cells must protect themselves from direct damag…
View article: <i>Aspergillus fumigatus</i> drives tissue damage via iterative assaults upon mucosal integrity and immune homeostasis
<i>Aspergillus fumigatus</i> drives tissue damage via iterative assaults upon mucosal integrity and immune homeostasis Open
The human lung is constantly exposed to Aspergillus fumigatus spores, the most prevalent worldwide cause of fungal respiratory disease. Pulmonary tissue damage is a unifying feature of Aspergillus -related diseases; however, the mechanisti…
View article: Cover Image: Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced by <i>Candida albicans</i> (Cellular Microbiology 10/2021)
Cover Image: Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced by <i>Candida albicans</i> (Cellular Microbiology 10/2021) Open
Candida albicans hyphae secreting the peptide toxin candidalysin (green) during invasion of epithelial cells. The toxin accumulates in the “invasion pocket” and damages the host cell. For further details, readers are referred to the articl…