Julian Swatler
YOU?
Author Swipe
View article: Lymph-node-derived stem-like but not tumor-tissue-resident CD8+ T cells fuel anticancer immunity
Lymph-node-derived stem-like but not tumor-tissue-resident CD8+ T cells fuel anticancer immunity Open
View article: Dystrophin Dp71 is essential for the development and function of macrophages
Dystrophin Dp71 is essential for the development and function of macrophages Open
Mutations in the DMD gene, encoding dystrophins, cause progressive muscle degeneration with severe sterile inflammation. While macrophages predominate amongst muscle-infiltrating cells, being central to both damage and regeneration, they w…
View article: 7aaRGD - a novel SPP1/integrin signaling-blocking peptide reverses immunosuppression and improves anti-PD-1 immunotherapy outcomes in experimental gliomas
7aaRGD - a novel SPP1/integrin signaling-blocking peptide reverses immunosuppression and improves anti-PD-1 immunotherapy outcomes in experimental gliomas Open
Background Immune checkpoint inhibitors (ICIs) present clinical benefits in many cancer patients but invariably fail in glioblastoma (GBM), the most common and deadly primary brain tumor. The lack of ICIs efficacy in GBM is attributed to t…
View article: Chitinase-3-like protein 1 depletion in glioma cells restricts myeloid cell infiltration and normalizes neovasculature in human glioma xenografts
Chitinase-3-like protein 1 depletion in glioma cells restricts myeloid cell infiltration and normalizes neovasculature in human glioma xenografts Open
Chitinase-3-like protein 1 (CHI3L1) is a secreted, non-enzymatic glycoprotein that interacts with cell-surface and extracellular-matrix proteins, proteoglycans, and polysaccharides. Many studies reported the overexpression of CHI3L1 in var…
View article: 7aaRGD - a novel SPP1/integrin signaling-blocking peptide reverses immunosuppression and improves anti-PD-1 immunotherapy outcomes in experimental gliomas
7aaRGD - a novel SPP1/integrin signaling-blocking peptide reverses immunosuppression and improves anti-PD-1 immunotherapy outcomes in experimental gliomas Open
Background Immune checkpoint inhibitors (ICIs) present clinical benefits in many cancer patients but invariably fail in glioblastoma (GBM), the most common and deadly primary brain tumor. The lack of ICIs efficacy in GBM is attributed to t…
View article: Identification of mutation-independent BRCA2 protein deficiency expands diagnostics and selection of pancreatic cancer patients for personalized therapy with PARP1 inhibitors
Identification of mutation-independent BRCA2 protein deficiency expands diagnostics and selection of pancreatic cancer patients for personalized therapy with PARP1 inhibitors Open
Background: Recently, therapies involving poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP1) inhibitors have been approved for metastatic BRCA1/2-mutated pancreatic ductal adenocarcinoma (PDAC). The current scheme of identificatio…
View article: Integrin blocking peptide reverses immunosuppression in experimental gliomas and improves anti-PD-1 therapy outcome
Integrin blocking peptide reverses immunosuppression in experimental gliomas and improves anti-PD-1 therapy outcome Open
Immune checkpoint inhibitors (ICI) presented clinical benefits in many cancer patients but invariably fail in glioblastoma (GBM), the most common and deadly primary brain tumor. Lack of ICI efficacy in GBM is attributed to the accumulation…
View article: Protocol for isolation of tumor-derived extracellular vesicles and functional studies on human T cell subsets
Protocol for isolation of tumor-derived extracellular vesicles and functional studies on human T cell subsets Open
View article: Tumors recycle glucocorticoids to drive Treg-mediated immunosuppression
Tumors recycle glucocorticoids to drive Treg-mediated immunosuppression Open
Suppression of antitumor immunity is a prominent feature of the tumor microenvironment. In this issue of the JCI, Taves, Otsuka, and authors show that glucocorticoids (GCs), which are potent immunosuppressive hormones mainly produced by th…
View article: Depletion of chitinase-3-like protein 1 (CHI3L1) in glioma cells restraints tumor growth and affects neovasculature in intracranial murine gliomas
Depletion of chitinase-3-like protein 1 (CHI3L1) in glioma cells restraints tumor growth and affects neovasculature in intracranial murine gliomas Open
Chitinase-3-like protein 1 (CHI3L1) is a secreted, non-enzymatic glycoprotein that binds proteins and carbohydrates and interacts with cell-surface and extracellular-matrix proteins, proteoglycans, and polysaccharides. Multiple interacting…
View article: Detailed characterization of SARS-CoV-2-specific T and B cells after infection or heterologous vaccination
Detailed characterization of SARS-CoV-2-specific T and B cells after infection or heterologous vaccination Open
The formation of a robust long-term antigen (Ag)-specific memory, both humoral and cell-mediated, is created following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or vaccination. Here, by using polychromatic flow…
View article: Specialized functions and sexual dimorphism explain the functional diversity of the myeloid populations during glioma progression
Specialized functions and sexual dimorphism explain the functional diversity of the myeloid populations during glioma progression Open
Malignant gliomas are aggressive, hard-to-treat brain tumors. Their tumor microenvironment is massively infiltrated by myeloid cells, mostly brain-resident microglia, bone marrow (BM)-derived monocytes/macrophages, and dendritic cells that…
View article: Targeting integrated stress response with ISRIB combined with imatinib treatment attenuates RAS/RAF/MAPK and STAT5 signaling and eradicates chronic myeloid leukemia cells
Targeting integrated stress response with ISRIB combined with imatinib treatment attenuates RAS/RAF/MAPK and STAT5 signaling and eradicates chronic myeloid leukemia cells Open
View article: Dysfunctional subsets of CD39+ T cells, distinct from PD-1+, driven by leukemic extracellular vesicles in myeloid leukemias
Dysfunctional subsets of CD39+ T cells, distinct from PD-1+, driven by leukemic extracellular vesicles in myeloid leukemias Open
Not available.
View article: ANGI-04. DEPLETION OF CHITINASE-3-LIKE PROTEIN 1 (CHI3L1) IN HUMAN U87-MG GLIOMA CELLS AFFECTS TUMOUR GROWTH AND NEOVASCULATURE IN INTRACRANIAL MOUSE MODEL
ANGI-04. DEPLETION OF CHITINASE-3-LIKE PROTEIN 1 (CHI3L1) IN HUMAN U87-MG GLIOMA CELLS AFFECTS TUMOUR GROWTH AND NEOVASCULATURE IN INTRACRANIAL MOUSE MODEL Open
Chitinase-3-like protein 1 (CHI3L1) plays multiple roles in inflammation, tissue remodelling, and wound healing. It is a new, potentially druggable target for the treatment of cancer due to its association with both extracellular matrix (E…
View article: Remodeling of T Cell Dynamics During Long COVID Is Dependent on Severity of SARS-CoV-2 Infection
Remodeling of T Cell Dynamics During Long COVID Is Dependent on Severity of SARS-CoV-2 Infection Open
Several COVID-19 convalescents suffer from the post-acute COVID-syndrome (PACS)/long COVID, with symptoms that include fatigue, dyspnea, pulmonary fibrosis, cognitive dysfunctions or even stroke. Given the scale of the worldwide infections…
View article: 4-1BBL–containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells
4-1BBL–containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells Open
Chronic and acute myeloid leukemia evade immune system surveillance and induce immunosuppression by expanding proleukemic Foxp3+ regulatory T cells (Tregs). High levels of immunosuppressive Tregs predict inferior response to chemotherapy, …
View article: 615 Reactivating antitumor immunity in gliomas with osteopontin/integrin blocking peptide
615 Reactivating antitumor immunity in gliomas with osteopontin/integrin blocking peptide Open
Background Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. Despite improvements in imaging, surgical techniques, radiotherapy and chemotherapy, the prognosis of patients with GBM remains poor with a medi…
View article: Targeting Integrated Stress Response by ISRIB combined with imatinib attenuates STAT5 signaling and eradicates therapy-resistant Chronic Myeloid Leukemia cells
Targeting Integrated Stress Response by ISRIB combined with imatinib attenuates STAT5 signaling and eradicates therapy-resistant Chronic Myeloid Leukemia cells Open
Integrated Stress Response (ISR) facilitates cellular adaptation to variable environmental conditions by reprogramming cellular response. Activation of ISR was reported in neurological disorders and solid tumours, but its function in hemat…
View article: Immunosuppressive Cell Subsets and Factors in Myeloid Leukemias
Immunosuppressive Cell Subsets and Factors in Myeloid Leukemias Open
Both chronic myeloid leukemia and acute myeloid leukemia evade the immune response during their development and disease progression. As myeloid leukemia cells modify their bone marrow microenvironment, they lead to dysfunction of cytotoxic…
View article: Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages
Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages Open
Microglia are resident myeloid cells in the central nervous system (CNS) that control homeostasis and protect CNS from damage and infections. Microglia and peripheral myeloid cells accumulate and adapt tumor supporting roles in human gliob…
View article: TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment
TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment Open
Synthetic lethality triggered by PARP inhibitor (PARPi) yields promising therapeutic results. Unfortunately, tumor cells acquire PARPi resistance, which is usually associated with the restoration of homologous recombination, loss of PARP1 …
View article: Chronic myeloid leukemia‐derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic regulatory T cells
Chronic myeloid leukemia‐derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic regulatory T cells Open
Mechanisms driving immunosuppression in chronic myeloid leukemia are mostly unknown. We show that leukemic extracellular vesicles (EVs) target lymphocytes and amplify suppressive function of thymic regulatory T cells, by driving expression…
View article: Not only gene mutation matters: Development of flow cytometry panel to determine BRCA2 deficiency for personalised therapy by PARP inhibitors in pancreatic cancers
Not only gene mutation matters: Development of flow cytometry panel to determine BRCA2 deficiency for personalised therapy by PARP inhibitors in pancreatic cancers Open
View article: Single-cell RNA sequencing reveals functional heterogeneity and sex differences of glioma-associated brain macrophages
Single-cell RNA sequencing reveals functional heterogeneity and sex differences of glioma-associated brain macrophages Open
Microglia are resident myeloid cells in the central nervous system (CNS) that control homeostasis and protect CNS from damage and infections. Microglia and peripheral myeloid cells accumulate and adapt tumor supporting roles in human gliob…
View article: Characteristics of live parameters of the HS‐5 human bone marrow stromal cell line cocultured with the leukemia cells in hypoxia, for the studies of leukemia–stroma cross‐talk
Characteristics of live parameters of the HS‐5 human bone marrow stromal cell line cocultured with the leukemia cells in hypoxia, for the studies of leukemia–stroma cross‐talk Open
The unique bone marrow microenvironment is created by stromal cells and such physical conditions as hypoxia. Both hypoxia and interactions with stromal cells have a significant impact on the biology of leukemia cells, changing their sensit…
View article: Insight into the Leukemia Microenvironment and Cell-cell Interactions Using Flow Cytometry
Insight into the Leukemia Microenvironment and Cell-cell Interactions Using Flow Cytometry Open
Cancer cells, including leukemia cells, reside in a complex microenvironment, which influences biology and activity of the cells. The protective role of bone marrow stromal cells is already commonly recognized. Remodeling of stroma cell fu…
View article: Immune checkpoint‑targeted cancer immunotherapies
Immune checkpoint‑targeted cancer immunotherapies Open
Tumor cells may express on their surface various characteristic antigens that can induce antitumor immunity. However, cancer in human body may induce an immunosuppressive microenvironment that limits immune response to its antigens. For ma…