Explanipedia

Dokumentationspflicht in der Zahnarztpraxis Open

Heinz-Theo Lübbers, Torsten Bergau, Julian T. Hoff, Jeannette von Jackowski · 2012

Früher war die ärztliche Dokumentation „Gedächtnisstütze“ für den Arzt oder Zahnarzt. Heute dient sie neben der zentralen Aufgabe als Stütze von Diagnostik und Therapie auch wesentlich der Absicherung gegen etwaige Haftungsansprüche sowie …

Brain edema Open

Julian T. Hoff, Richard F. Keep, Guohua Xi · 2007

Brain Injury After Intracerebral Hemorrhage Open

Ya Hua, Richard F. Keep, Julian T. Hoff, Guohua Xi · 2007

Intracerebral hemorrhage (ICH) is a subtype of stroke with high morbidity and mortality. The mechanisms underlying ICH-induced brain injury have become better understood during the past decade. Experimental investigations have indicated th…

The Deleterious or Beneficial Effects of Different Agents in Intracerebral Hemorrhage Open

Richard F. Keep, Guohua Xi, Ya Hua, Julian T. Hoff · 2005

Background and Purpose— Thrombin, heme oxygenase, complement, microglia activation, and leukocyte infiltration are all actively upregulated in intracerebral hemorrhage (ICH). Experimental evidence suggests that all these factors are involv…

Holo-Transferrin and Thrombin Can Interact to Cause Brain Damage Open

Takehiro Nakamura, Guohua Xi, Jung-Weon Park, Ya Hua, Julian T. Hoff , et al. · 2005

Background and Purpose— Previous studies have suggested that delayed release of hemoglobin degradation products, particularly iron, is involved in intracerebral hemorrhage (ICH)–induced brain injury. However, a recent study found evidence …

Intracerebral Hemorrhage Open

Ye Gong, Ya Hua, Richard F. Keep, Julian T. Hoff, Guohua Xi · 2004

Background and Purpose— Intracerebral hemorrhage (ICH) is mostly a disease of the elderly, but most current experimental ICH models have used young animals. Age is an important factor in other forms of brain injury, affecting microglia and…

Editorial Comment—International Variations in Surgical Practice for Spontaneous Intracerebral Hemorrhage Open

Julian T. Hoff · 2003

Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage Open

Takehiro Nakamura, Richard F. Keep, Ya Hua, Timothy Schallert, Julian T. Hoff , et al. · 2003

Object In the authors' previous studies they found that brain iron accumulation and oxidative stress contribute to secondary brain damage after intracerebral hemorrhage (ICH). In the present study they investigated whether deferoxamine, an…

Spontaneous intracerebral hemorrhage: a review Open

Matthew E. Fewel, B. Gregory Thompson, Julian T. Hoff · 2003

Spontaneous intracerebral hemorrhage (SICH) is a blood clot that arises in the brain parenchyma in the absence of trauma or surgery. This entity accounts for 10 to 15% of all strokes and is associated with a higher mortality rate than eith…

Donald J. Reis, MD: Research Mentor Extraordinaire Open

Julian T. Hoff · 2003

Delayed Argatroban Treatment Reduces Edema in a Rat Model of Intracerebral Hemorrhage Open

Takuji Kitaoka, Ya Hua, Guohua Xi, Julian T. Hoff, Richard F. Keep · 2002

Background and Purpose— Studies indicate that thrombin plays an important role in intracerebral hemorrhage (ICH)–induced edema formation. Although thrombin is produced as the blood clots, it may be bound to fibrin and only gradually releas…

Hypoxia-Inducible Factor-1α Accumulation in the Brain after Experimental Intracerebral Hemorrhage Open

Yajun Jiang, Jimin Wu, Richard F. Keep, Ya Hua, Julian T. Hoff , et al. · 2002

Hypoxia-inducible factor-1 (HIF-1), a transcription factor composed of HIF-1α and HIF-1β protein subunits, has been implicated in cellular protection and cell death in cerebral ischemia. The extent to which HIF-1 plays a role in brain path…

Thrombin-Receptor Activation and Thrombin-Induced Brain Tolerance Open

Yajun Jiang, Jimin Wu, Ya Hua, Richard F. Keep, Jianming Xiang , et al. · 2002

The authors previously found that pretreatment with a low dose of thrombin attenuates the brain edema induced by a large dose of thrombin or an intracerebral hemorrhage, and reduces infarct volume after focal cerebral ischemia (i.e., throm…

Plasminogen Activator Inhibitor-1 Induction after Experimental Intracerebral Hemorrhage Open

Ya Hua, Guohua Xi, Richard F. Keep, Jimin Wu, Yajun Jiang , et al. · 2002

Serine proteases, such as thrombin and tissue-type plasminogen activator, play an important role in brain injury after intracerebral hemorrhage and other neurologic disorders. Plasminogen activator inhibitor-1 is one of the serine protease…

Systemic Complement Depletion Diminishes Perihematomal Brain Edema in Rats Open

Guohua Xi, Ya Hua, Richard F. Keep, John G. Younger, Julian T. Hoff · 2001

Background and Purpose —The complement cascade is activated after experimental intracerebral hemorrhage (ICH). It remains unclear, however, whether depleting the complement system will improve injury resulting from ICH. This study investig…

Four Early Contributors to Neurosurgery in North America Open

Julian T. Hoff · 2000

The lives of four physicians of the past are described, focusing on their unique contributions to the early development of neurosurgery in the United States and Canada. Each influenced the others during these formative years, and each play…

Attenuation of Thrombin-Induced Brain Edema by Cerebral Thrombin Preconditioning Open

Guohua Xi, Richard F. Keep, Ya Hua, Jianming Xiang, Julian T. Hoff · 1999

Background and Purpose —Edema formation after intracerebral hemorrhage has been linked to thrombin toxicity induced by the clot. However, thrombin at low concentrations actually protects neurons and astrocytes in culture from hypoglycemic …

Role of Blood Clot Formation on Early Edema Development After Experimental Intracerebral Hemorrhage Open

Guohua Xi, Kenneth R. Wagner, Richard F. Keep, Ya Hua, Gabrielle M. de Courten‐Myers , et al. · 1998

Background and Purpose —Blood “toxicity” is hypothesized to induce edema and brain tissue injury following intracerebral hemorrhage (ICH). Lobar ICH in pigs produces rapidly developing, marked perihematomal edema (>10% increase in water co…

Plasminogen Activators Potentiate Thrombin-Induced Brain Injury Open

Bryan E. Figueroa, Richard F. Keep, A. Lorris Betz, Julian T. Hoff · 1998

Background and Purpose —Evidence suggests that cerebral edema following intracerebral hemorrhage (ICH) results from a mass effect in combination with neurotoxic injury from clot-derived substrates such as thrombin. Thrombolytics can compet…

CJN volume 23 issue 4 Cover and Front matter Open

Sumeer Lai, V Rajala, Robert Raju, Rajendra Macaulay, C Lee , et al. · 1996

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

EDITOR'S PERSPECTIVE ON ARTICLE 1 Open

Kevin R. Lee, Nobuyuki Kawai, Seoung Kim, Oren Sagher, Julian T. Hoff · 1996

The authors use a highly reproducible model to simulate spontaneous intracerebral hemorrhage in rats.The progressive mass effect that develops over several days after hemorrhage is largely due to edema formation in brain parenchyma adjacen…

EDITOR'S INTRODUCTION TO INTRACEREBRAL HEMORRHAGE: TREATMENT OPTIONS AND OUTCOME Open

Julian T. Hoff · 1996

The papers in this month's edition of Neurosurgical Focus concern intracerebral hemorrhage, a common problem for all neurosurgeons.Intracerebral hemorrhage from a variety of sources continues to be a major cause of morbidity and mortality …

Mechanisms of edema formation after intracerebral hemorrhage: effects of thrombin on cerebral blood flow, blood-brain barrier permeability, and cell survival in a rat model Open

Kevin R. Lee, Nobuyuki Kawai, Seoung Kim, Oren Sagher, Julian T. Hoff · 1996

Recently, the authors showed that thrombin contributes to the formation of brain edema following intracerebral hemorrhage. The current study examines whether the action of thrombin is due to an effect on cerebral blood flow (CBF), vasoreac…

CJN volume 23 issue 2 Cover and Front matter Open

Robert A. Hauser, Theresa A. Zesiewicz, Carlos R. Martinez, Alexander Rosemurgy, C.W. Olanow , et al. · 1996

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

CJN volume 22 issue 3 Cover and Front matter Open

Gary Dix, William J. Gordon, Anthony M. Kaufmann, Ian Sutherland, Garnette R. Sutherland , et al. · 1995

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

CJN volume 21 issue 3 Cover and Front matter Open

Atilano Lacson, Shashi S. Seshia, Harvey B. Sarnat, Jocelyn Anderson, William J. deGroot , et al. · 1994

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

CJN volume 21 issue S2 Cover and Front matter Open

James Toronto, Laurence E. Becker, John London, Terry Ottawa, R. Lee , et al. · 1994

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

CJN volume 21 issue 2 Cover and Front Matter Open

Alicia Osimani, Masanori Ichise, Dae-Gyun Chung, Janice Pogue, Morris Freedman , et al. · 1994

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

CJN volume 21 issue 1 Cover and Front matter Open

Jane E. Francis, S. John Mihic, W. Bruce Sneddon, W. Dean Burnham, John D. Fisk , et al. · 1994

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

CJN Volume 20 issue 4 Cover and Front matter Open

Robert Chen, P. Ashby, Michael McKenzie, Luís Souhami, Jean‐Louis Caron , et al. · 1993

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Julian T. Hoff YOU? Author Swipe