Juliane Grimm
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View article: Quantifying <i>NPM1</i> MRD in AML patients prior to allogeneic stem cell transplantation: Where to draw the line?
Quantifying <i>NPM1</i> MRD in AML patients prior to allogeneic stem cell transplantation: Where to draw the line? Open
Today, assessment of measurable residual disease (MRD) increasingly allows a dynamic risk stratification and informs treatment decisions in acute myeloid leukemia (AML).1 For AML patients with NPM1 gene mutations quantitative PCR methods h…
View article: An iron rheostat controls hematopoietic stem cell fate
An iron rheostat controls hematopoietic stem cell fate Open
Mechanisms governing the maintenance of blood-producing hematopoietic stem and multipotent progenitor cells (HSPCs) are incompletely understood, particularly those regulating fate, ensuring long-term maintenance, and preventing aging-assoc…
View article: Prognostic impact of measurable residual clonal hematopoiesis in acute myeloid leukemia patients after allogeneic hematopoietic stem cell transplantation
Prognostic impact of measurable residual clonal hematopoiesis in acute myeloid leukemia patients after allogeneic hematopoietic stem cell transplantation Open
Graphical Abstract
View article: Evolving trends in the surgical therapy of patients with endometrial cancer in Germany: analysis of a nationwide registry with special emphasis on perioperative outcomes
Evolving trends in the surgical therapy of patients with endometrial cancer in Germany: analysis of a nationwide registry with special emphasis on perioperative outcomes Open
Purpose Endometrial cancer (EC) is the most common gynecological malignancy in women, with increasing incidence in the last decades. Surgical therapy is the mainstay of the initial management. The present study analyzed the evolving trends…
View article: Evolving Trends in the Surgical Therapy of Patients with Endometrial Cancer in Germany: Analysis of a Nationwide Registry with Special Emphasis on Perioperative Outcomes
Evolving Trends in the Surgical Therapy of Patients with Endometrial Cancer in Germany: Analysis of a Nationwide Registry with Special Emphasis on Perioperative Outcomes Open
Purpose Endometrial cancer (EC) is the most common gynecological malignancy in women, with increasing incidence in the last decades. Surgical therapy is the mainstay of the initial management. The present study analyzed the evolving trends…
View article: Impact of<i>IDH1</i>and<i>IDH2</i>mutation detection at diagnosis and in remission in patients with AML receiving allogeneic transplantation
Impact of<i>IDH1</i>and<i>IDH2</i>mutation detection at diagnosis and in remission in patients with AML receiving allogeneic transplantation Open
Somatic mutations in the isocitrate dehydrogenase 1 and 2 genes (IDH1 and IDH2) are common in acute myeloid leukemia (AML). The prognostic impact of the presence of IDH mutations may be influenced by the comutational status, the specific l…
View article: Combining LSD1 and JAK-STAT inhibition targets Down syndrome-associated myeloid leukemia at its core
Combining LSD1 and JAK-STAT inhibition targets Down syndrome-associated myeloid leukemia at its core Open
Children with Down syndrome (DS) are predisposed to developing megakaryoblastic leukemia (ML-DS) and often experience severe toxicities from chemotherapy, highlighting the need for targeted therapies with beneficial risk profiles. The geno…
View article: Clinical implications of <scp><i>SRSF2</i></scp> mutations in <scp>AML</scp> patients undergoing allogeneic stem cell transplantation
Clinical implications of <span><i>SRSF2</i></span> mutations in <span>AML</span> patients undergoing allogeneic stem cell transplantation Open
The SRSF2 mutations are frequently found in acute myeloid leukemia (AML) and mostly affect the P95 residue. Mutations in this splicing factor mediate abnormal splicing associated with exon skipping events, including EZH2 as a crucial targe…
View article: Peritoneal inclusion cyst in a patient with glycogen storage disease type Ib and Crohn’s like disease
Peritoneal inclusion cyst in a patient with glycogen storage disease type Ib and Crohn’s like disease Open
Background Glycogen storage disease type Ib (GSD Ib) due to biallelic mutations in SLC37A4 is often associated with inflammatory bowel disease. Peritoneal inclusion cysts (PICs) are variable sized, fluid-filled, mesothelial-lined cysts tha…
View article: Clinical value of the measurable residual disease status within the <scp>ELN2017</scp> risk groups in <scp>AML</scp> patients undergoing allogeneic stem cell transplantation
Clinical value of the measurable residual disease status within the <span>ELN2017</span> risk groups in <span>AML</span> patients undergoing allogeneic stem cell transplantation Open
To the Editor: Over recent years, the clinical value of measurable residual disease (MRD) status in acute myeloid leukemia (AML) for informed treatment decisions became increasingly evident.1 Even though several aspects with respect to MRD…
View article: Molecular Mechanisms of the Genetic Predisposition to Acute Megakaryoblastic Leukemia in Infants With Down Syndrome
Molecular Mechanisms of the Genetic Predisposition to Acute Megakaryoblastic Leukemia in Infants With Down Syndrome Open
Individuals with Down syndrome are genetically predisposed to developing acute megakaryoblastic leukemia. This myeloid leukemia associated with Down syndrome (ML–DS) demonstrates a model of step-wise leukemogenesis with perturbed hematopoi…
View article: Prognostic impact of rapid reduction of involved free light chains in multiple myeloma patients under first-line treatment with Bendamustine, Prednisone, and Bortezomib (BPV)
Prognostic impact of rapid reduction of involved free light chains in multiple myeloma patients under first-line treatment with Bendamustine, Prednisone, and Bortezomib (BPV) Open
Introduction Light chain involvement is observed in almost every patient (pt) with newly diagnosed multiple myeloma (MM). Owing to a relatively short half-life, rapid reduction in the involved free light chain (iFLC) is of potential progno…
View article: Prognostic impact of the ELN2017 risk classification in patients with AML receiving allogeneic transplantation
Prognostic impact of the ELN2017 risk classification in patients with AML receiving allogeneic transplantation Open
In 2017, an updated European LeukemiaNet (ELN) risk classification was published allocating patients with acute myeloid leukemia (AML) to 3 risk groups on the basis of certain cytogenetic and molecular aberrations. To date, studies of the …
View article: Outcomes of Older Patients with <i>NPM1</i> Mutated and <i>FLT3</i>‐ITD Negative Acute Myeloid Leukemia Receiving Allogeneic Transplantation
Outcomes of Older Patients with <i>NPM1</i> Mutated and <i>FLT3</i>‐ITD Negative Acute Myeloid Leukemia Receiving Allogeneic Transplantation Open
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View article: Comparison of non‐myeloablative and reduced‐intensity allogeneic stem cell transplantation in older patients with myelodysplastic syndromes
Comparison of non‐myeloablative and reduced‐intensity allogeneic stem cell transplantation in older patients with myelodysplastic syndromes Open
Allogeneic stem cell transplantation (HSCT) remains the only curative treatment for myelodysplastic syndromes (MDS) or myelodysplastic/myeloproliferative neoplasms (MDS/MPN) patients. The introduction of reduced intensity (RIC) and non‐mye…
View article: Pretreatment CD34+/CD38– Cell Burden as Prognostic Factor in Myelodysplastic Syndrome Patients Receiving Allogeneic Stem Cell Transplantation
Pretreatment CD34+/CD38– Cell Burden as Prognostic Factor in Myelodysplastic Syndrome Patients Receiving Allogeneic Stem Cell Transplantation Open
Myelodysplastic syndrome (MDS) is a highly heterogeneous clonal hematopoietic disorder. Allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative treatment and is of particular interest in patients at high risk fo…
View article: Prognostic Impact of Blood <i>MN1</i> Copy Numbers Before Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia
Prognostic Impact of Blood <i>MN1</i> Copy Numbers Before Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia Open
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View article: High <i>BAALC</i> copy numbers in peripheral blood prior to allogeneic transplantation predict early relapse in acute myeloid leukemia patients
High <i>BAALC</i> copy numbers in peripheral blood prior to allogeneic transplantation predict early relapse in acute myeloid leukemia patients Open
High BAALC expression levels at acute myeloid leukemia diagnosis have been linked to adverse outcomes. Recent data indicate that high BAALC expression levels may also be used as marker for residual disease following acute myeloid leukemia …