Juliane Nees
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View article: Can the organic coating of breast tissue markers be sampled by an ultrasound-guided core cut biopsy without removing the clip marker? A proof-of-concept evaluation of two coated clip marker types in turkey breast tissue to improve representativity of ultrasound-guided core cut biopsies
Can the organic coating of breast tissue markers be sampled by an ultrasound-guided core cut biopsy without removing the clip marker? A proof-of-concept evaluation of two coated clip marker types in turkey breast tissue to improve representativity of ultrasound-guided core cut biopsies Open
Purpose: The aim of this preclinical study was to test if the organic coating of two breast tissue clip markers (HydroMARK and UltraClip) can be sampled selectively by an ultrasound-guided core cut biopsy. Methods: Ten clip markers of each…
View article: Cancer risk in carriers of <i>TP53</i> germline variants grouped into different functional categories
Cancer risk in carriers of <i>TP53</i> germline variants grouped into different functional categories Open
Li-Fraumeni syndrome is a cancer predisposition syndrome caused by pathogenic TP53 germline variants; it is associated with a high lifelong cancer risk. We analyzed the German Li-Fraumeni syndrome registry, which contains data on 304 indiv…
View article: Unmet Supportive Care Needs in Adults With Li–Fraumeni Syndrome: A Mixed‐Methods Study
Unmet Supportive Care Needs in Adults With Li–Fraumeni Syndrome: A Mixed‐Methods Study Open
Introduction: Individuals with Li–Fraumeni syndrome (LFS) face an increased risk for multiple cancers. LFS is caused by pathogenic variants in the TP53 gene and individuals with LFS are recommended intense cancer surveillance programs to i…
View article: Evaluation of Ex Vivo Shear Wave Elastography of Axillary Sentinel Lymph Nodes in Patients with Early Breast Cancer
Evaluation of Ex Vivo Shear Wave Elastography of Axillary Sentinel Lymph Nodes in Patients with Early Breast Cancer Open
Background: The pretherapeutic assessment of axillary lymph node status is crucial in staging early breast cancer patients, significantly influencing their further treatment and prognosis. According to current guidelines, patients with cli…
View article: Shear-wave elastography as a supplementary tool for axillary staging in patients undergoing breast cancer diagnosis
Shear-wave elastography as a supplementary tool for axillary staging in patients undergoing breast cancer diagnosis Open
View article: 147P Racial bias in pretreatment MRI radiomics features to predict response to neoadjuvant systemic treatment in breast cancer: A multicenter study in China, Germany, and the US
147P Racial bias in pretreatment MRI radiomics features to predict response to neoadjuvant systemic treatment in breast cancer: A multicenter study in China, Germany, and the US Open
Machine learning with radiomics showed great potential to predict response to neoadjuvant systemic treatment (NAST) for breast cancer. However, performance across different ethnicities and potential racial bias remain unclear. We aimed to …
View article: Health‐related quality of life and fear of progression in individuals with <scp>Li‐Fraumeni</scp> syndrome
Health‐related quality of life and fear of progression in individuals with <span>Li‐Fraumeni</span> syndrome Open
Li‐Fraumeni syndrome (LFS) is a rare autosomal dominant cancer predisposition syndrome associated with a highly elevated lifetime cancer risk. This and the recommended intense surveillance program represent a large psychological burden on …
View article: Ultrasound Radiomics Features to Identify Patients With Triple‐Negative Breast Cancer
Ultrasound Radiomics Features to Identify Patients With Triple‐Negative Breast Cancer Open
Objectives Patients with triple‐negative breast cancer (TNBC) exhibit a fast tumor growth rate and poor survival outcomes. In this study, we aimed to develop and compare intelligent algorithms using ultrasound radiomics features in additio…
View article: Medical students’ knowledge on cancer predisposition syndromes and attitude toward eHealth
Medical students’ knowledge on cancer predisposition syndromes and attitude toward eHealth Open
Purpose Individuals with cancer predisposition syndromes (CPS) inherit elevated cancer risks. Medical supply gaps for people at risk of CPS cause insufficient outreach and miss potential benefits of individualized care strategies. Increase…
View article: Intra‐ and Interobserver Reliability of Shear Wave Elastography in Breast Cancer Diagnosis
Intra‐ and Interobserver Reliability of Shear Wave Elastography in Breast Cancer Diagnosis Open
Objectives Shear wave elastography (SWE) is increasingly used in breast cancer diagnostics. However, large, prospective, multicenter data evaluating the reliability of SWE is missing. We evaluated the intra‐ and interobserver reliability o…
View article: Can multi-modal radiomics using pretreatment ultrasound and tomosynthesis predict response to neoadjuvant systemic treatment in breast cancer?
Can multi-modal radiomics using pretreatment ultrasound and tomosynthesis predict response to neoadjuvant systemic treatment in breast cancer? Open
View article: Liver stiffness in pregnant women with intrahepatic cholestasis of pregnancy: A case control study
Liver stiffness in pregnant women with intrahepatic cholestasis of pregnancy: A case control study Open
Metabolic-associated fatty liver disease (MAFLD) is one of the most common chronic liver diseases worldwide. In recent years, the occurrence rate of MAFLD has been on the rise, mainly due to lifestyle changes, high-calorie diets, and imbal…
View article: Conventional specimen radiography in breast-conserving therapy: a useful tool for intraoperative margin assessment after neoadjuvant therapy?
Conventional specimen radiography in breast-conserving therapy: a useful tool for intraoperative margin assessment after neoadjuvant therapy? Open
View article: Conventional specimen radiography in breast conserving therapy: A useful tool for intraoperative margin assessment after neoadjuvant chemotherapy?
Conventional specimen radiography in breast conserving therapy: A useful tool for intraoperative margin assessment after neoadjuvant chemotherapy? Open
Purpose A previous study in our breast unit showed that the diagnostic accuracy of intraoperative specimen radiography and its potential to reduce second surgeries in a cohort of patients treated with neoadjuvant chemotherapy were low, whi…
View article: Imaging of lumpectomy surface with large field-of-view confocal laser scanning microscopy ‘Histolog® scanner’ for breast margin assessment in comparison with conventional specimen radiography
Imaging of lumpectomy surface with large field-of-view confocal laser scanning microscopy ‘Histolog® scanner’ for breast margin assessment in comparison with conventional specimen radiography Open
View article: Potential of Lesion‐to‐Fat Elasticity Ratio Measured by Shear Wave Elastography to Reduce Benign Biopsies in <scp>BI‐RADS</scp> 4 Breast Lesions
Potential of Lesion‐to‐Fat Elasticity Ratio Measured by Shear Wave Elastography to Reduce Benign Biopsies in <span>BI‐RADS</span> 4 Breast Lesions Open
Objectives We evaluated whether lesion‐to‐fat ratio measured by shear wave elastography in patients with Breast Imaging Reporting and Data System (BI‐RADS) 3 or 4 lesions has the potential to further refine the assessment of B‐mode ultraso…
View article: Can the organic coating of breast tissue markers be sampled by an ultrasound-guided core cut biopsy without removing the clip marker? A proof-of-concept evaluation of two coated clip marker types in turkey breast tissue to improve representativity of ultrasound-guided core cut biopsies.
Can the organic coating of breast tissue markers be sampled by an ultrasound-guided core cut biopsy without removing the clip marker? A proof-of-concept evaluation of two coated clip marker types in turkey breast tissue to improve representativity of ultrasound-guided core cut biopsies. Open
The aim of this preclinical study was to test if the organic coating of two breast tissue clip markers (HydroMARK and UltraClip) can be sampled selectively by an ultrasound-guided core cut biopsy (CC). Ten clip markers of each type were in…
View article: Health Behavior and Cancer Prevention among Adults with Li-Fraumeni Syndrome and Relatives in Germany—A Cohort Description
Health Behavior and Cancer Prevention among Adults with Li-Fraumeni Syndrome and Relatives in Germany—A Cohort Description Open
Li-Fraumeni-syndrome (LFS) is a rare, highly penetrant cancer predisposition syndrome (CPS) caused by pathogenic variants (PVs) in TP53. Physical activity (PA) and a Mediterranean diet lead to cancer reduction or survival benefits and incr…
View article: Shear wave elastography as a supplemental tool in the assessment of unsuspicious axillary lymph nodes in patients undergoing breast ultrasound examination
Shear wave elastography as a supplemental tool in the assessment of unsuspicious axillary lymph nodes in patients undergoing breast ultrasound examination Open
Objectives: To define reference values for shear wave elastography (SWE) in unsuspicious axillary lymph nodes in patients undergoing breast ultrasound examination. Methods: In total, 177 clinically and sonographically unsuspicious axillary…
View article: Genotype–phenotype associations within the Li-Fraumeni spectrum: a report from the German Registry
Genotype–phenotype associations within the Li-Fraumeni spectrum: a report from the German Registry Open
View article: How previous treatment changes the metabolomic profile in patients with metastatic breast cancer
How previous treatment changes the metabolomic profile in patients with metastatic breast cancer Open
Purpose Metabolites are in the spotlight of attention as promising novel breast cancer biomarkers. However, no study has been conducted concerning changes in the metabolomics profile of metastatic breast cancer patients according to previo…
View article: Potential of blood-based biomarker approaches in endometrium and breast cancer: a case-control comparison study
Potential of blood-based biomarker approaches in endometrium and breast cancer: a case-control comparison study Open
View article: The importance of multi-modal imaging and clinical information for humans and AI-based algorithms to classify breast masses (INSPiRED 003): an international, multicenter analysis
The importance of multi-modal imaging and clinical information for humans and AI-based algorithms to classify breast masses (INSPiRED 003): an international, multicenter analysis Open
Objectives AI-based algorithms for medical image analysis showed comparable performance to human image readers. However, in practice, diagnoses are made using multiple imaging modalities alongside other data sources. We determined the impo…
View article: Additional file 1 of Genotype–phenotype associations within the Li-Fraumeni spectrum: a report from the German Registry
Additional file 1 of Genotype–phenotype associations within the Li-Fraumeni spectrum: a report from the German Registry Open
Additional file 1. TP53 (NM_000546.5) variants, functional data categories, and associated phenotypes. Abbreviations: Acute lymphatic leukemia (ALL), acute myeloid leukemia (AML), adrenocortical carcinoma (ACC), bilateral (bilat), breast c…
View article: Does conventional specimen radiography after neoadjuvant chemotherapy of breast cancer help to reduce the rate of second surgeries?
Does conventional specimen radiography after neoadjuvant chemotherapy of breast cancer help to reduce the rate of second surgeries? Open
Purpose This is the first study to systematically evaluate the diagnostic accuracy of intraoperative specimen radiography on margin level and its potential to reduce second surgeries in patients treated with neoadjuvant chemotherapy. Metho…
View article: Does Conventional Specimen Radiography After Neoadjuvant Chemotherapy of Breast Cancer Help To Reduce The Rate of Second Surgeries?
Does Conventional Specimen Radiography After Neoadjuvant Chemotherapy of Breast Cancer Help To Reduce The Rate of Second Surgeries? Open
PurposeThis is the first study to systematically evaluate the diagnostic accuracy of intraoperative specimen radiography on margin level and its potential to reduce second surgeries in patients treated with neoadjuvant chemotherapy. Method…
View article: A New Practical Decision Rule to Better Differentiate <scp>BI‐RADS</scp> 3 or 4 Breast Masses on Breast Ultrasound
A New Practical Decision Rule to Better Differentiate <span>BI‐RADS</span> 3 or 4 Breast Masses on Breast Ultrasound Open
Objectives The BI‐RADS classification provides a standardized way to describe ultrasound findings in breast cancer diagnostics. However, there is little information regarding which BI‐RADS descriptors are most strongly associated with mali…
View article: Evaluation of the FUSION-X-US-II prototype to combine automated breast ultrasound and tomosynthesis
Evaluation of the FUSION-X-US-II prototype to combine automated breast ultrasound and tomosynthesis Open
View article: Estrogen, progesterone, and human epidermal growth factor receptor 2 discordance between primary and metastatic breast cancer
Estrogen, progesterone, and human epidermal growth factor receptor 2 discordance between primary and metastatic breast cancer Open
View article: HER2-targeted therapy influences CTC status in metastatic breast cancer
HER2-targeted therapy influences CTC status in metastatic breast cancer Open