Juliane Schulze
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View article: Lack of Negative Feedback Loops of CTLA-4 and PD-L1 as Key Mechanisms for Post-Acute T Cell Activation Until 3 Months After Ischemic Stroke
Lack of Negative Feedback Loops of CTLA-4 and PD-L1 as Key Mechanisms for Post-Acute T Cell Activation Until 3 Months After Ischemic Stroke Open
Post-stroke T lymphocytes exert differential effects both at the infarction site and systemically; these are pro-inflammatory cascades, subsequent T cell infiltration into the brain, and persisting interaction of infiltrating T lymphocytes…
View article: Antigen-Specifically Activated CD8+ and Double-Negative T Cells Accumulate in the Brain of Alzheimer’s Disease Mice
Antigen-Specifically Activated CD8+ and Double-Negative T Cells Accumulate in the Brain of Alzheimer’s Disease Mice Open
Emerging evidence suggests adaptive immunity plays a key role in cognitive function and neurodegenerative diseases. However, the specific contribution of T cells in Alzheimer's disease (AD) remains poorly understood. Despite successful T c…
View article: Discrete state-dependent profiles of increased CX3CL1 in cerebrospinal fluid and serum t-Tau elevations in migraine: results from a cross-sectional case-control study
Discrete state-dependent profiles of increased CX3CL1 in cerebrospinal fluid and serum t-Tau elevations in migraine: results from a cross-sectional case-control study Open
Background & Objectives: T o date, migraine is diagnosed exclusively based on clinical criteria, but fluid biomarkers are desirable to gain insight into pathophysiological processes and inform clinical management. We investigated the state…
View article: Effects of body mass index on the immune response within the first days after major stroke in humans
Effects of body mass index on the immune response within the first days after major stroke in humans Open
Introduction Immunological alterations associated with increased susceptibility to infection are an essential aspect of stroke pathophysiology. Several immunological functions of adipose tissue are altered by obesity and are accompanied by…
View article: Neurotrophin-3 attenuates human peripheral blood T cell and monocyte activation status and cytokine production post stroke
Neurotrophin-3 attenuates human peripheral blood T cell and monocyte activation status and cytokine production post stroke Open
NT-3 attenuated immune responses in cells from stroke patients and controls. The mechanism whereby human immune cells respond to NT-3 may be via TrkC receptors whose levels are regulated by stimulation. Further work is required to determin…
View article: Central Nervous System-Infiltrating T Lymphocytes in Stroke Are Activated via Their TCR (T-Cell Receptor) but Lack CD25 Expression
Central Nervous System-Infiltrating T Lymphocytes in Stroke Are Activated via Their TCR (T-Cell Receptor) but Lack CD25 Expression Open
Background and Purpose: T lymphocytes contribute to secondary brain damage after stroke. It has not been fully investigated whether this contribution is caused by antigen-specific or antigen-nonspecific activation of T lymphocytes. Lymphoc…
View article: Stroke-Induced Modulation of Myeloid-Derived Suppressor Cells (MDSCs) and IL-10-Producing Regulatory Monocytes
Stroke-Induced Modulation of Myeloid-Derived Suppressor Cells (MDSCs) and IL-10-Producing Regulatory Monocytes Open
Background: Stroke patients are at risk of acquiring secondary infections due to stroke-induced immune suppression (SIIS). Immunosuppressive cells comprise myeloid-derived suppressor cells (MDSCs) and immunosuppressive interleukin 10 (IL-1…
View article: Corrigendum: Clinical Improvement Following Stroke Promptly Reverses Post-stroke Cellular Immune Alterations
Corrigendum: Clinical Improvement Following Stroke Promptly Reverses Post-stroke Cellular Immune Alterations Open
[This corrects the article DOI: 10.3389/fneur.2019.00414.].
View article: Spermine and spermidine modulate T-cell function in older adults with and without cognitive decline ex vivo
Spermine and spermidine modulate T-cell function in older adults with and without cognitive decline ex vivo Open
The global increase in neurodegenerative disorders is one of the most crucial public health issues. Oral polyamine intake was shown to improve memory performance which is thought to be mediated at least in part via increased autophagy indu…
View article: Clinical Improvement Following Stroke Promptly Reverses Post-stroke Cellular Immune Alterations
Clinical Improvement Following Stroke Promptly Reverses Post-stroke Cellular Immune Alterations Open
Background and Purpose: Stroke induces immediate profound alterations of the peripheral immune system rendering patients more susceptible to post-stroke infections. The precise mechanisms maintaining stroke-induced immune alterations (SIIA…
View article: Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke
Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke Open
Immune cells can significantly predict and affect the clinical outcome of stroke. In particular, the neutrophil-to-lymphocyte ratio was shown to predict hemorrhagic transformation and the clinical outcome of stroke; however, the immunologi…
View article: Reduced Numbers and Impaired Function of Regulatory T Cells in Peripheral Blood of Ischemic Stroke Patients
Reduced Numbers and Impaired Function of Regulatory T Cells in Peripheral Blood of Ischemic Stroke Patients Open
Background and Purpose . Regulatory T cells (Tregs) have been suggested to modulate stroke-induced immune responses. However, analyses of Tregs in patients and in experimental stroke have yielded contradictory findings. We performed the cu…
View article: A comparative analysis of the creative ecology of cultural and creative Industries in UK and the Southern European countries: lace market versus Portugal, Spain and Greece
A comparative analysis of the creative ecology of cultural and creative Industries in UK and the Southern European countries: lace market versus Portugal, Spain and Greece Open
The unique ecology of Nottingham’s creative industry sector was the inspiration for CINET, the creative industries network funded by the EU’s Leonardo programme. CINET is a Leonardo da Vinci Transfer of Innovation Project funded by the Eur…