Julianne Jin
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View article: Characterizing and controlling CRISPR repair outcomes in nondividing human cells
Characterizing and controlling CRISPR repair outcomes in nondividing human cells Open
Genome editing is poised to revolutionize treatment of genetic diseases, but poor understanding and control of DNA repair outcomes hinders its therapeutic potential. DNA repair is especially understudied in nondividing cells like neurons, …
View article: Characterizing and controlling CRISPR repair outcomes in nondividing human cells
Characterizing and controlling CRISPR repair outcomes in nondividing human cells Open
Genome editing is poised to revolutionize treatment of genetic diseases, but poor understanding and control of DNA repair outcomes hinders its therapeutic potential. DNA repair is especially understudied in nondividing cells like neurons, …
View article: 66 QVT Score, a radiomic biomarker of tumor vascularity, enables immune checkpoint inhibitor (ICI) outcome prediction and early survival assessment in NSCLC
66 QVT Score, a radiomic biomarker of tumor vascularity, enables immune checkpoint inhibitor (ICI) outcome prediction and early survival assessment in NSCLC Open
View article: 33 Tumor-informed circulating tumor DNA assay as a prognostic tool for detecting relapse in patients with non-small cell lung cancer receiving curative treatment
33 Tumor-informed circulating tumor DNA assay as a prognostic tool for detecting relapse in patients with non-small cell lung cancer receiving curative treatment Open
View article: Neuronal DNA repair reveals strategies to influence CRISPR editing outcomes
Neuronal DNA repair reveals strategies to influence CRISPR editing outcomes Open
Genome editing is poised to revolutionize treatment of genetic diseases, but poor understanding and control of DNA repair outcomes hinders its therapeutic potential. DNA repair is especially understudied in nondividing cells like neurons, …
View article: Multi-omic phenotyping of iPSC-derived neurons harboring the <i>MAPT</i> V337M mutation reveals tau hypophosphorylation and perturbed axon morphology pathways
Multi-omic phenotyping of iPSC-derived neurons harboring the <i>MAPT</i> V337M mutation reveals tau hypophosphorylation and perturbed axon morphology pathways Open
Tau aggregation is a hallmark of several neurodegenerative diseases, including Alzheimer’s disease and frontotemporal dementia. There are disease-causing variants of the tau-encoding gene, MAPT , and the presence of tau aggregates is highl…