Julie A. Farley
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View article: Progressive cognitive impairment after recovery from neuroinvasive and non-neuroinvasive Listeria monocytogenes infection
Progressive cognitive impairment after recovery from neuroinvasive and non-neuroinvasive Listeria monocytogenes infection Open
Background Neuro-cognitive impairment is a deleterious complication of bacterial infections that is difficult to treat or prevent. Listeria monocytogenes ( Lm ) is a neuroinvasive bacterial pathogen and commonly used model organism for stu…
View article: Systemic infection of mice with neuroinvasive Listeria monocytogenes triggers cognitive decline and persistent increases in brain CD8+ T-lymphocyte populations
Systemic infection of mice with neuroinvasive Listeria monocytogenes triggers cognitive decline and persistent increases in brain CD8+ T-lymphocyte populations Open
Background: Leukocytes recruited into the central nervous system after infection help clear pathogens and provide long-lasting immune surveillance, but also can contribute to harmful post-infectious neuroinflammation. Listeria monocytogene…
View article: Adulthood Deficiency of the Insulin-like Growth Factor-1 Receptor in Hippocampal Neurons Impairs Cell Structure and Spatial Learning and Memory in Male and Not Female Mice
Adulthood Deficiency of the Insulin-like Growth Factor-1 Receptor in Hippocampal Neurons Impairs Cell Structure and Spatial Learning and Memory in Male and Not Female Mice Open
Reductions in insulin-like growth factor-1 (IGF-1) are associated with cognitive impairment and increased risk of neurodegenerative disease in advanced age. In mouse models, reduced IGF-1 early-in-life leads to memory impairments and synap…
View article: Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice
Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice Open
Cognitive decline with age is a harmful process that can reduce quality of life. Multiple factors have been established to contribute to cognitive decline, but the overall etiology remains unknown. Here, we hypothesized that cognitive dysf…
View article: Disparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function
Disparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function Open
Age-related decline in circulating levels of insulin-like growth factor (IGF)-1 is associated with reduced cognitive function, neuronal aging, and neurodegeneration. Decreased mitochondrial function along with increased reactive oxygen spe…
View article: Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes
Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes Open
Regulation of astrocytic mitochondrial function and redox status by IGF-1 is essential to maintain astrocytic function and coordinate hippocampal-dependent spatial learning. Age-related astrocytic dysfunction caused by diminished IGF-1 sig…