Julie A. Johnson
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View article: Graduate Student Features: Research Report by Joseph Johnson
Graduate Student Features: Research Report by Joseph Johnson Open
Research Report by Joseph Johnson
View article: Healthcare access and utilization of deep brain stimulation and supplementary care in black and white patients with Parkinson's disease
Healthcare access and utilization of deep brain stimulation and supplementary care in black and white patients with Parkinson's disease Open
Black patients are less likely to have DBS implantation, evaluation, and acceptance but more likely to have supplementary care compared to White patients. These new findings could help improve healthcare.
View article: Recipient Versus Donor <i>CYP3A4/5</i> Genotypes in Adult Liver Transplant Recipients to Achieve Therapeutic Tacrolimus Concentrations Early Post‐Transplant
Recipient Versus Donor <i>CYP3A4/5</i> Genotypes in Adult Liver Transplant Recipients to Achieve Therapeutic Tacrolimus Concentrations Early Post‐Transplant Open
Tacrolimus is an immunosuppressive agent with difficult dosing due to a narrow therapeutic index and large interpatient pharmacokinetic variability, for which CYP3A5 variation plays a role. Tacrolimus/ CYP3A5 pharmacogenetic guidelines exc…
View article: Scoping review of associations between cytochrome P450 3A4/5 single nucleotide polymorphisms and risk factors for fentanyl overdose
Scoping review of associations between cytochrome P450 3A4/5 single nucleotide polymorphisms and risk factors for fentanyl overdose Open
Evidence from 64 studies suggested that the no-function CYP3A5 * 3 (rs776746) allele contributes to increased fentanyl overdose risk, with strongest support coming from studies of fentanyl pharmacokinetics in clinical settings. Ther…
View article: <i>CYP2D6</i> Phenotypes and Emergency Department Visits Among Patients Receiving Opioid Treatment
<i>CYP2D6</i> Phenotypes and Emergency Department Visits Among Patients Receiving Opioid Treatment Open
Importance Cytochrome P450 2D6 ( CYP2D6 ) bioactivates hydrocodone, tramadol, codeine, and oxycodone to active metabolites that primarily provide analgesic activity. Reduced CYP2D6 activity may be associated with poor pain control. Objecti…
View article: Evaluation of Potential Racial Disparities in CYP2C19‐Guided P2Y12 Inhibitor Prescribing After Percutaneous Coronary Intervention
Evaluation of Potential Racial Disparities in CYP2C19‐Guided P2Y12 Inhibitor Prescribing After Percutaneous Coronary Intervention Open
Black patients suffer worse outcomes after percutaneous coronary intervention (PCI) than White patients. Inequities in antiplatelet prescribing may contribute to this health disparity. We compared P2Y12 inhibitor prescribing by …
View article: In vitro comparative analysis of metabolic capabilities and inhibitory profiles of selected CYP2D6 alleles on tramadol metabolism
In vitro comparative analysis of metabolic capabilities and inhibitory profiles of selected CYP2D6 alleles on tramadol metabolism Open
Tramadol, the 41st most prescribed drug in the United States in 2021 is a prodrug activated by CYP2D6, which is highly polymorphic. Previous studies showed enzyme‐inhibitor affinity varied between different CYP2D6 allelic variants with dex…
View article: Pharmacogenetics: Opportunities for the All of Us Research Program and Other Large Data Sets to Advance the Field
Pharmacogenetics: Opportunities for the All of Us Research Program and Other Large Data Sets to Advance the Field Open
Pharmacogenetic variation is common and an established driver of response for many drugs. There has been tremendous progress in pharmacogenetics knowledge over the last 30 years and in clinical implementation of that knowledge over the las…
View article: Meta-analysis of genome-wide association studies of stable warfarin dose in patients of African ancestry
Meta-analysis of genome-wide association studies of stable warfarin dose in patients of African ancestry Open
Warfarin dose requirements are highly variable because of clinical and genetic factors. Although genetic variants influencing warfarin dose have been identified in European and East Asian populations, more work is needed to identify Africa…
View article: Implementing a pragmatic clinical trial to tailor opioids for chronic pain on behalf of the <scp>IGNITE ADOPT PGx</scp> investigators
Implementing a pragmatic clinical trial to tailor opioids for chronic pain on behalf of the <span>IGNITE ADOPT PGx</span> investigators Open
Chronic pain is a prevalent condition with enormous economic burden. Opioids such as tramadol, codeine, and hydrocodone are commonly used to treat chronic pain; these drugs are activated to more potent opioid receptor agonists by the hepat…
View article: <i>CYP2C19</i> Genotype Is Associated With Adverse Cardiovascular Outcomes in Black Patients Treated With Clopidogrel Undergoing Percutaneous Coronary Intervention
<i>CYP2C19</i> Genotype Is Associated With Adverse Cardiovascular Outcomes in Black Patients Treated With Clopidogrel Undergoing Percutaneous Coronary Intervention Open
Background Cytochrome P450 2C19 (CYP2C19) intermediate and poor metabolizer patients exhibit diminished clopidogrel clinical effectiveness after percutaneous coronary intervention (PCI). However, outcome studies to date have lacked racial …
View article: Rationale and design for a pragmatic randomized trial to assess <scp>gene‐based</scp> prescribing for <scp>SSRIs</scp> in the treatment of depression
Rationale and design for a pragmatic randomized trial to assess <span>gene‐based</span> prescribing for <span>SSRIs</span> in the treatment of depression Open
Specific selective serotonin reuptake inhibitors (SSRIs) metabolism is strongly influenced by two pharmacogenes, CYP2D6 and CYP2C19 . However, the effectiveness of prospectively using pharmacogenetic variants to select or dose SSRIs for de…
View article: Integrated metabolomics analysis reveals mechanistic insights into variability in blood pressure response to thiazide diuretics and beta blockers
Integrated metabolomics analysis reveals mechanistic insights into variability in blood pressure response to thiazide diuretics and beta blockers Open
Hypertensive patients with a higher proportion of genetic West African ancestry (%GWAA) have better blood pressure (BP) response to thiazide diuretics (TDs) and worse response to β‐blockers (BBs) than those with lower %GWAA, associated wit…
View article: Effectiveness of Clopidogrel vs Alternative P2Y12 Inhibitors Based on the ABCD-GENE Score
Effectiveness of Clopidogrel vs Alternative P2Y12 Inhibitors Based on the ABCD-GENE Score Open
View article: Circulating microRNA Biomarkers of Thiazide Response in Hypertension
Circulating microRNA Biomarkers of Thiazide Response in Hypertension Open
Background Thiazide diuretics are the second most frequently prescribed class of antihypertensives, but up to 50% of patients with hypertension have minimal antihypertensive response to thiazides. We explored circulating microRNAs (miRNAs)…
View article: Evaluating the impact of sickle cell disease on COVID-19 susceptibility and severity: a retrospective cohort study based on electronic health record
Evaluating the impact of sickle cell disease on COVID-19 susceptibility and severity: a retrospective cohort study based on electronic health record Open
Background Sickle cell trait/disease (SCT/SCD) are enriched among Black people and associated with various comorbidities. The overrepresentation of these characteristics prevents traditional regression approach obtaining convincing evidenc…
View article: A Pharmacogenetics-Based Approach to Managing Gastroesophageal Reflux Disease: Current Perspectives and Future Steps
A Pharmacogenetics-Based Approach to Managing Gastroesophageal Reflux Disease: Current Perspectives and Future Steps Open
Proton pump inhibitors (PPIs) are commonly used medications to treat acid-related conditions, including gastro-esophageal reflux disease (GERD). Gastroenterology guidelines mention the importance of CYP2C19 in PPI metabolism and the influe…
View article: Use of a multi-gene pharmacogenetic panel reduces adverse drug effects
Use of a multi-gene pharmacogenetic panel reduces adverse drug effects Open
View article: Sociome Data Commons: A scalable and sustainable platform for investigating the full social context and determinants of health
Sociome Data Commons: A scalable and sustainable platform for investigating the full social context and determinants of health Open
Background/Objective: Non-clinical aspects of life, such as social, environmental, behavioral, psychological, and economic factors, what we call the sociome, play significant roles in shaping patient health and health outcomes. This paper …
View article: CYP2D6 pharmacogenetics and phenoconversion in personalized medicine
CYP2D6 pharmacogenetics and phenoconversion in personalized medicine Open
Considering the extent and impact of genetic polymorphisms of CYP2D6, phenoconversion by the comedications, and contribution of CYP2D6 in drug metabolism, CYP2D6 pharmacogenetics is essential to ensure drug safety and efficac…
View article: 12 The potential for eye donationfrom hospice and palliative care clinical settings in England – a retrospective case notes review of deceased patient records
12 The potential for eye donationfrom hospice and palliative care clinical settings in England – a retrospective case notes review of deceased patient records Open
Significant potential exists for eye donation from the clinical sites in this study. This potential is not currently being realised. In view of the predicted increase in need for ophthalmic tissue it is essential that the potential route t…
View article: Body Mass Index and Overall Survival of Patients with Newly Diagnosed Multiple Myeloma
Body Mass Index and Overall Survival of Patients with Newly Diagnosed Multiple Myeloma Open
Obesity is associated with survival in several solid tumors and non-Hodgkin lymphoma, but its impact on multiple myeloma (MM) survival is unclear. We examined the associations between body mass index (BMI) at different periods of life up t…
View article: Evaluation of Potential Racial Disparities in<i>CYP2C19</i>‐Guided P2Y<sub>12</sub>Inhibitor Prescribing After Percutaneous Coronary Intervention
Evaluation of Potential Racial Disparities in<i>CYP2C19</i>‐Guided P2Y<sub>12</sub>Inhibitor Prescribing After Percutaneous Coronary Intervention Open
Black patients suffer worse outcomes after percutaneous coronary intervention (PCI) than White patients. Inequities in antiplatelet prescribing may contribute to this health disparity. We compared P2Y 12 inhibitor prescribing by race follo…
View article: Pairwise comparison of hydrochlorothiazide and chlorthalidone responses among hypertensive patients
Pairwise comparison of hydrochlorothiazide and chlorthalidone responses among hypertensive patients Open
This study conducted a pairwise comparison of antihypertensive and metabolic effects of hydrochlorothiazide (HCTZ) and chlorthalidone (CTD) at 25 mg/day in the same individuals to address the clinical dilemma on preferred thiazide for hype…
View article: Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke
Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke Open
The ABO locus, genetically predicted blood group A, and higher genetic propensity for venous thrombosis are more strongly associated with EOS than with LOS, supporting a stronger role of prothrombotic factors in EOS.
View article: Influence of Genetic West African Ancestry on Metabolomics among Hypertensive Patients
Influence of Genetic West African Ancestry on Metabolomics among Hypertensive Patients Open
Patients with higher genetic West African ancestry (GWAA) have hypertension (HTN) that is more difficult to treat and have higher rates of cardiovascular diseases (CVD) and differential responses to antihypertensive drugs than those with l…
View article: Implementing a pragmatic clinical trial to tailor opioids for acute pain on behalf of the <scp>IGNITE ADOPT PGx</scp> investigators
Implementing a pragmatic clinical trial to tailor opioids for acute pain on behalf of the <span>IGNITE ADOPT PGx</span> investigators Open
Opioid prescribing for postoperative pain management is challenging because of inter‐patient variability in opioid response and concern about opioid addiction. Tramadol, hydrocodone, and codeine depend on the cytochrome P450 2D6 (CYP2D6) e…
View article: Genetic Contributors of Efficacy and Adverse Metabolic Effects of Chlorthalidone in African Americans from the Genetics of Hypertension Associated Treatments (GenHAT) Study
Genetic Contributors of Efficacy and Adverse Metabolic Effects of Chlorthalidone in African Americans from the Genetics of Hypertension Associated Treatments (GenHAT) Study Open
Hypertension is a leading risk factor for cardiovascular disease mortality. African Americans (AAs) have the highest prevalence of hypertension in the United States, and to alleviate the burden of hypertension in this population, better co…
View article: Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis
Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis Open
Background: The knowledge of factors influencing disease progression in patients with established coronary heart disease (CHD) is still relatively limited. One potential pathway is related to peroxisome proliferator–activated receptor gamm…
View article: Design and rationale of GUARDD-US: A pragmatic, randomized trial of genetic testing for APOL1 and pharmacogenomic predictors of antihypertensive efficacy in patients with hypertension
Design and rationale of GUARDD-US: A pragmatic, randomized trial of genetic testing for APOL1 and pharmacogenomic predictors of antihypertensive efficacy in patients with hypertension Open