Julie Bakker
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View article: Ventromedial hypothalamus (VMHvl) nNOS neurons regulate social behaviors in a sex-specific manner
Ventromedial hypothalamus (VMHvl) nNOS neurons regulate social behaviors in a sex-specific manner Open
Neuronal nitric oxide synthase (nNOS) neurons are ubiquitously spread in the mouse brain. Data using knockouts and pharmacology have revealed that nNOS is essential for the display of sexual and aggressive behavior. Yet, the specific neuro…
View article: EndoCompass Project: Research Roadmap for Reproductive and Developmental Endocrinology
EndoCompass Project: Research Roadmap for Reproductive and Developmental Endocrinology Open
Background: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal im…
View article: EndoCompass project: research roadmap for reproductive and developmental endocrinology
EndoCompass project: research roadmap for reproductive and developmental endocrinology Open
Background Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impa…
View article: Ventromedial hypothalamus (VMHvl) nNOS neurons regulate social behaviors in a sex-specific manner
Ventromedial hypothalamus (VMHvl) nNOS neurons regulate social behaviors in a sex-specific manner Open
Neuronal nitric oxide synthase (nNOS) neurons are ubiquitously spread in the rodent brain. Data using knockouts and pharmacology have revealed that nNOS is essential for the display of sexual and aggressive behavior. Yet, the specific neur…
View article: Mapping hypothalamic development in transgender and cisgender youth
Mapping hypothalamic development in transgender and cisgender youth Open
The neurodevelopmental basis of gender incongruence is poorly understood. Histological studies have suggested sex-atypical hypothalamic structures in transgender individuals, forming the basis for the brain sexual differentiation hypothesi…
View article: Enhanced identification of endocrine disruptors through integration of science-based regulatory practices and innovative methodologies: The MERLON Project
Enhanced identification of endocrine disruptors through integration of science-based regulatory practices and innovative methodologies: The MERLON Project Open
The prevalence of hormone-related health issues caused by exposure to endocrine disrupting chemicals (EDCs) is a significant, and increasing, societal challenge. Declining fertility rates together with rising incidence rates of reproductiv…
View article: NPRC-Social isolation and aggression training lead to escalated aggression and hypothalamus-pituitary-gonad axis hyperfunction in mice
NPRC-Social isolation and aggression training lead to escalated aggression and hypothalamus-pituitary-gonad axis hyperfunction in mice Open
Although the participation of sex hormones and sex hormone-responsive neurons in aggressive behavior has been extensively studied, the role of other systems within the hypothalamus-pituitary-gonadal (HPG) axis remains elusive. Here we asse…
View article: HYPOTHALAMIC NNOS NEURONS REGULATE SOCIAL BEHAVIORS IN A SEX-SPECIFIC MANNER
HYPOTHALAMIC NNOS NEURONS REGULATE SOCIAL BEHAVIORS IN A SEX-SPECIFIC MANNER Open
Estrogen receptor alpha (Erα)-positive neurons within the ventrolateral part of the ventromedial nucleus of the hypothalamus (VMHvl) are essential for the display of mating and fighting in mice, regardless of sex. Yet, the role of other VM…
View article: Neuroendocrine regulation of female aggression
Neuroendocrine regulation of female aggression Open
Classically the neurobiology of aggression has been studied exclusively in males. Thus, females have been considered mildly aggressive except during lactation. Interestingly, recent studies in rodents and humans have revealed that non-lact…
View article: The role of steroid hormones in the sexual differentiation of the human brain
The role of steroid hormones in the sexual differentiation of the human brain Open
Widespread sex differences in human brain structure and function have been reported. Research on animal models has demonstrated that sex differences in brain and behavior are induced by steroid hormones during specific, hormone sensitive, …
View article: Consensus Parameter: Research Methodologies to Evaluate Neurodevelopmental Effects of Pubertal Suppression in Transgender Youth
Consensus Parameter: Research Methodologies to Evaluate Neurodevelopmental Effects of Pubertal Suppression in Transgender Youth Open
Purpose: Pubertal suppression is standard of care for early pubertal transgender youth to prevent the development of undesired and distressing secondary sex characteristics incongruent with gender identity. Preliminary evidence suggests pu…
View article: The Role of Kisspeptin in Sexual Behavior
The Role of Kisspeptin in Sexual Behavior Open
Sexual behavior is essential for the perpetuation of a species. In female rodents, mate preference and lordosis behavior depend heavily on the integration of olfactory cues into the neuroendocrine brain, yet its underlying neural circuits …
View article: Age‐related changes in the morphology of tanycytes in the human female infundibular nucleus/median eminence
Age‐related changes in the morphology of tanycytes in the human female infundibular nucleus/median eminence Open
Tanycytes are emerging as key players in the neuroendocrine control of gonadotrophin‐releasing hormone (Gn RH ) release. Rodent studies have demonstrated that the structural relationship between tanycytes and Gn RH terminals in the median …
View article: The influence of sex hormones and sex chromosomes on the sexual differentiation of human brain structure: analysis of regional gray matter in women with complete androgen insensitivity syndrome
The influence of sex hormones and sex chromosomes on the sexual differentiation of human brain structure: analysis of regional gray matter in women with complete androgen insensitivity syndrome Open
Event Abstract Back to Event The influence of sex hormones and sex chromosomes on the sexual differentiation of human brain structure: analysis of regional gray matter in women with complete androgen insensitivity syndrome Marine Manard1*,…
View article: Male-typical visuospatial functioning in gynephilic girls with gender dysphoria — organizational and activational effects of testosterone
Male-typical visuospatial functioning in gynephilic girls with gender dysphoria — organizational and activational effects of testosterone Open
Background: Sex differences in performance and regional brain activity during mental rotation have been reported repeatedly and reflect organizational and activational effects of sex hormones. We investigated whether adolescent girls with …
View article: Estradiol‐induced neurogenesis in the female accessory olfactory bulb is required for the learning of the male odor
Estradiol‐induced neurogenesis in the female accessory olfactory bulb is required for the learning of the male odor Open
Odors processed by the main and accessory olfactory bulbs ( MOB , AOB ) are important for sexual behavior. Interestingly, both structures continue to receive new neurons during adulthood. A role for olfactory neurogenesis in sexual behavio…
View article: Kisspeptin Expression in the Human Infundibular Nucleus in Relation to Sex, Gender Identity, and Sexual Orientation
Kisspeptin Expression in the Human Infundibular Nucleus in Relation to Sex, Gender Identity, and Sexual Orientation Open
Context: Since the discovery of its central role in reproduction, our functional neuroanatomical knowledge of the hypothalamic kisspeptin system is predominantly based on animal studies. Although sex differences in kisspeptin expression ha…