Julie Callison
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View article: Immunological correlates of protection afforded by PHV02 live, attenuated recombinant vesicular stomatitis virus vector vaccine against Nipah virus disease
Immunological correlates of protection afforded by PHV02 live, attenuated recombinant vesicular stomatitis virus vector vaccine against Nipah virus disease Open
Introduction Immune correlates of protection afforded by PHV02, a recombinant vesicular stomatitis (rVSV) vector vaccine against Nipah virus (NiV) disease, were investigated in the African green monkey (AGM) model. Neutralizing antibody to…
View article: Single-Dose Treatment With Vesicular Stomatitis Virus–Based Ebola Virus Vaccine Expressing Ebola Virus–Specific Artificial Micro-RNA Does Not Protect Mice From Lethal Disease
Single-Dose Treatment With Vesicular Stomatitis Virus–Based Ebola Virus Vaccine Expressing Ebola Virus–Specific Artificial Micro-RNA Does Not Protect Mice From Lethal Disease Open
Although significant progress has been made in the development of therapeutics against Ebola virus (EBOV), we sought to expand upon existing strategies and combine an RNA interference–based intervention with the approved vesicular stomatit…
View article: Combined molnupiravir-nirmatrelvir treatment improves the inhibitory effect on SARS-CoV-2 in macaques
Combined molnupiravir-nirmatrelvir treatment improves the inhibitory effect on SARS-CoV-2 in macaques Open
The periodic emergence of SARS-CoV-2 variants of concern (VOCs) with unpredictable clinical severity and ability to escape preexisting immunity emphasizes the continued need for antiviral interventions. Two small molecule inhibitors, molnu…
View article: Distinct VSV-based Nipah virus vaccines expressing either glycoprotein G or fusion protein F provide homologous and heterologous protection in a nonhuman primate model
Distinct VSV-based Nipah virus vaccines expressing either glycoprotein G or fusion protein F provide homologous and heterologous protection in a nonhuman primate model Open
This study was supported by the Intramural Research Program, NIAID, NIH.
View article: Combined Molnupiravir and Nirmatrelvir Treatment Improves the Inhibitory Effect on SARS-CoV-2 in Rhesus Macaques
Combined Molnupiravir and Nirmatrelvir Treatment Improves the Inhibitory Effect on SARS-CoV-2 in Rhesus Macaques Open
The periodic emergence of SARS-CoV-2 variants of concern (VOCs) with unpredictable clinical severity and ability to escape preexisting immunity emphasizes the continued need for antiviral interventions. Two small molecule inhibitors, molnu…
View article: Development of a nonhuman primate model for mammalian bornavirus infection
Development of a nonhuman primate model for mammalian bornavirus infection Open
Until recently, it was assumed that members of the family Bornaviridae could not induce severe disease in humans. Today, however, Borna disease virus 1 (BoDV-1), as well as the more recently emerged variegated squirrel bornavirus 1 (VSBV-1…
View article: Three-Week Old Pigs Are Not Susceptible to Productive Infection with SARS-COV-2
Three-Week Old Pigs Are Not Susceptible to Productive Infection with SARS-COV-2 Open
As the COVID-19 pandemic moves into its third year, there remains a need for additional animal models better recapitulating severe COVID to study SARS-CoV-2 pathogenesis and develop countermeasures, especially treatment options. Pigs are k…
View article: Single Dose of a VSV-Based Vaccine Rapidly Protects Macaques From Marburg Virus Disease
Single Dose of a VSV-Based Vaccine Rapidly Protects Macaques From Marburg Virus Disease Open
Marburg virus (MARV) is a member of the filovirus family that causes hemorrhagic disease with high case fatality rates. MARV is on the priority list of the World Health Organization for countermeasure development highlighting its potential…
View article: Favipiravir (T-705) Protects IFNAR−/− Mice against Lethal Zika Virus Infection in a Sex-Dependent Manner
Favipiravir (T-705) Protects IFNAR−/− Mice against Lethal Zika Virus Infection in a Sex-Dependent Manner Open
Zika virus (ZIKV), a member of the Flaviviridae family, is an important human pathogen that has caused epidemics in Africa, Southeast Asia, and the Americas. No licensed treatments for ZIKV disease are currently available. Favipiravir (T-7…
View article: Ebola Virus IgG Seroprevalence in Southern Mali
Ebola Virus IgG Seroprevalence in Southern Mali Open
Mali had 2 reported introductions of Ebola virus (EBOV) during the 2013-2016 West Africa epidemic. Previously, no evidence for EBOV circulation was reported in Mali. We performed an EBOV serosurvey study in southern Mali. We found low sero…
View article: A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques
A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques Open
SUMMARY The deployment of a vaccine that limits transmission and disease likely will be required to end the Coronavirus Disease 2019 (COVID-19) pandemic. We recently described the protective activity of an intranasally-administered chimpan…
View article: UK B.1.1.7 (Alpha) variant exhibits increased respiratory replication and shedding in nonhuman primates
UK B.1.1.7 (Alpha) variant exhibits increased respiratory replication and shedding in nonhuman primates Open
The continuing emergence of SARS-CoV-2 variants calls for regular assessment to identify differences in viral replication, shedding and associated disease. In this study, we compared African green monkeys infected intranasally with either …
View article: Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models
Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models Open
We remain largely without effective prophylactic/therapeutic interventions for COVID-19. Although many human COVID-19 clinical trials are ongoing, there remains a deficiency of supportive preclinical drug efficacy studies to help guide dec…
View article: Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2
Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2 Open
We remain largely without effective prophylactic/therapeutic interventions for COVID-19. Although many human clinical trials are ongoing, there remains a deficiency of supportive preclinical drug efficacy studies. Here we assessed the prop…
View article: Respiratory disease and virus shedding in rhesus macaques inoculated with SARS-CoV-2
Respiratory disease and virus shedding in rhesus macaques inoculated with SARS-CoV-2 Open
An outbreak of a novel coronavirus, now named SARS-CoV-2, causing respiratory disease and a ∼2% case fatality rate started in Wuhan, China in December 2019. Following unprecedented rapid global spread, the World Health Organization declare…
View article: Protection Against Marburg Virus Using a Recombinant VSV-Vaccine Depends on T and B Cell Activation
Protection Against Marburg Virus Using a Recombinant VSV-Vaccine Depends on T and B Cell Activation Open
Marburg virus (MARV) is the causative agent of hemorrhagic fever outbreaks with high case fatality rates. Closely related to Ebola virus, MARV is a filamentous virus with a negative-sense, single-stranded RNA genome. Although extensive stu…
View article: A VSV-based Zika virus vaccine protects mice from lethal challenge
A VSV-based Zika virus vaccine protects mice from lethal challenge Open
Infection with Zika virus (ZIKV) is commonly mild in humans but has been associated with alarming negative health outcomes including Guillain-Barré syndrome in adults and microcephaly in fetuses. As such, developing a vaccine for ZIKV is a…
View article: Lethal Zika Virus Disease Models in Young and Older Interferon α/β Receptor Knock Out Mice
Lethal Zika Virus Disease Models in Young and Older Interferon α/β Receptor Knock Out Mice Open
The common small animal disease models for Zika virus (ZIKV) are mice lacking the interferon responses, but infection of interferon receptor α/β knock out (IFNAR-/-) mice is not uniformly lethal particularly in older animals. Here we sough…