Julie Helms
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View article: Hemostasis disorders: from bleeding to thrombosis
Hemostasis disorders: from bleeding to thrombosis Open
View article: Heat stress-induced mitochondrial damage and its impact on leukocyte function
Heat stress-induced mitochondrial damage and its impact on leukocyte function Open
Heatstroke is characterized by systemic inflammation, immune dysregulation, and multiorgan failure, in which mitochondrial damage in leukocytes plays a pivotal role. This review examines the mechanisms by which heat stress induces leukocyt…
View article: Long-term cardiovascular complications in COVID-19 survivors according to disease severity
Long-term cardiovascular complications in COVID-19 survivors according to disease severity Open
Post-sepsis syndrome is a major concern affecting sepsis survivors. COVID-19 increases the risk of long-term complications, but existing data lack detail on patient-specific factors and long-term cardiovascular complications, namely major …
View article: Corticosteroids in non-viral community-acquired pneumonia: edging closer to “yes”
Corticosteroids in non-viral community-acquired pneumonia: edging closer to “yes” Open
View article: Association between mean hemodynamic variables during the first 24 h and outcomes in cardiogenic shock: identification of clinically relevant thresholds
Association between mean hemodynamic variables during the first 24 h and outcomes in cardiogenic shock: identification of clinically relevant thresholds Open
View article: The role of viscoelastic tests in the diagnosis of sepsis-induced coagulopathy (SIC)
The role of viscoelastic tests in the diagnosis of sepsis-induced coagulopathy (SIC) Open
View article: Biomarkers of sepsis-induced coagulopathy: diagnostic insights and potential therapeutic implications
Biomarkers of sepsis-induced coagulopathy: diagnostic insights and potential therapeutic implications Open
Diagnosing coagulopathy in septic patients remains challenging in intensive care. Disseminated intravascular coagulation (DIC) indeed presents with complex pathophysiology, complicating timely diagnosis. Epidemiological data indicate a sig…
View article: Impact of hyper- and hypothermia on cellular and whole-body physiology
Impact of hyper- and hypothermia on cellular and whole-body physiology Open
View article: Alteplase in COVID-19 severe hypoxemic respiratory failure: the TRISTARDS multicenter randomized trial
Alteplase in COVID-19 severe hypoxemic respiratory failure: the TRISTARDS multicenter randomized trial Open
View article: Autophagy and autophagic cell death in sepsis: friend or foe?
Autophagy and autophagic cell death in sepsis: friend or foe? Open
In sepsis, inflammation, and nutrient deficiencies endanger cellular homeostasis and survival. Autophagy is primarily a mechanism of cellular survival under fasting conditions. However, autophagy-dependent cell death, known as autophagic c…
View article: Sepsis-induced coagulopathy (SIC) in the management of sepsis
Sepsis-induced coagulopathy (SIC) in the management of sepsis Open
The mortality rate of sepsis remains high and further increases when complicated by disseminated intravascular coagulation (DIC). Consequently, early detection and appropriate management of DIC will be helpful for the management of sepsis.…
View article: Oxygen therapy in acute hypoxemic respiratory failure: guidelines from the SRLF-SFMU consensus conference
Oxygen therapy in acute hypoxemic respiratory failure: guidelines from the SRLF-SFMU consensus conference Open
View article: Barriers to female leadership in intensive care medicine: insights from an ESICM NEXT & Diversity Monitoring Group Survey
Barriers to female leadership in intensive care medicine: insights from an ESICM NEXT & Diversity Monitoring Group Survey Open
View article: Sex differences in the SOFA score of ICU patients with sepsis or septic shock: a nationwide analysis
Sex differences in the SOFA score of ICU patients with sepsis or septic shock: a nationwide analysis Open
Background The Sequential Organ Failure Assessment (SOFA) score is an important tool in diagnosing sepsis and quantifying organ dysfunction. However, despite emerging evidence of differences in sepsis pathophysiology between women and men,…
View article: Refining trial design in sepsis management: balancing realism with ideal outcomes
Refining trial design in sepsis management: balancing realism with ideal outcomes Open
View article: Determining prognostic indicator for anticoagulant therapy in sepsis-induced disseminated intravascular coagulation
Determining prognostic indicator for anticoagulant therapy in sepsis-induced disseminated intravascular coagulation Open
Background There is no reliable indicator that can assess the treatment effect of anticoagulant therapy for sepsis-associated disseminated intravascular coagulation (DIC) in the short term. The aim of this study is to develop and validate …
View article: Correction: Management of hematological patients requiring emergency chemotherapy in the intensive care unit
Correction: Management of hematological patients requiring emergency chemotherapy in the intensive care unit Open
View article: Management of hematological patients requiring emergency chemotherapy in the intensive care unit
Management of hematological patients requiring emergency chemotherapy in the intensive care unit Open
View article: Managing sepsis and septic shock in an endothelial glycocalyx-friendly way: from the viewpoint of surviving sepsis campaign guidelines
Managing sepsis and septic shock in an endothelial glycocalyx-friendly way: from the viewpoint of surviving sepsis campaign guidelines Open
View article: Correction: Contemporary management of major haemorrhage in critical care
Correction: Contemporary management of major haemorrhage in critical care Open
View article: The Detection of Neutrophil Activation by Automated Blood Cell Counter in Sepsis
The Detection of Neutrophil Activation by Automated Blood Cell Counter in Sepsis Open
Neutrophils serve as the frontline defenders in the host's response to infections. However, the available methods for assessing the activated status of neutrophils are still limited. The immature cells that appear during sepsis are large w…
View article: TLRs1-10 Protein Expression in Circulating Human White Blood Cells during Bacterial and COVID-19 Infections
TLRs1-10 Protein Expression in Circulating Human White Blood Cells during Bacterial and COVID-19 Infections Open
Introduction: Toll-like receptors play crucial roles in the sepsis-induced systemic inflammatory response. Septic shock mortality correlates with overexpression of neutrophilic TLR2 and TLR9, while the role of TLR4 overexpression remains a…
View article: Disseminated intravascular coagulation is strongly associated with severe acute kidney injury in patients with septic shock
Disseminated intravascular coagulation is strongly associated with severe acute kidney injury in patients with septic shock Open
View article: Mechanisms and management of the coagulopathy of trauma and sepsis: trauma-induced coagulopathy, sepsis-induced coagulopathy, and disseminated intravascular coagulation
Mechanisms and management of the coagulopathy of trauma and sepsis: trauma-induced coagulopathy, sepsis-induced coagulopathy, and disseminated intravascular coagulation Open
View article: Sex and gender differences in intensive care medicine
Sex and gender differences in intensive care medicine Open
View article: Defining heparin resistance: communication from the ISTH SSC Subcommittee of Perioperative and Critical Care Thrombosis and Hemostasis
Defining heparin resistance: communication from the ISTH SSC Subcommittee of Perioperative and Critical Care Thrombosis and Hemostasis Open
View article: Differential effect on mortality of the timing of initiation of renal replacement therapy according to the criteria used to diagnose acute kidney injury: an IDEAL-ICU substudy
Differential effect on mortality of the timing of initiation of renal replacement therapy according to the criteria used to diagnose acute kidney injury: an IDEAL-ICU substudy Open
View article: Extracranial anticoagulant related bleedings admitted to intensive care units: a French multicenter retrospective study
Extracranial anticoagulant related bleedings admitted to intensive care units: a French multicenter retrospective study Open
Background Anticoagulants are widely used but can lead to iatrogenic events such as bleeding. Limited data exists regarding the characteristics and management of patients admitted to intensive care units (ICU) for severe anticoagulant-rela…
View article: Staphylococcus epidermidis bloodstream infections are a cause of septic shock in intensive care unit patients
Staphylococcus epidermidis bloodstream infections are a cause of septic shock in intensive care unit patients Open
View article: Treatment of immunothrombosis dysregulation: high-dose corticosteroids is not the good option
Treatment of immunothrombosis dysregulation: high-dose corticosteroids is not the good option Open