Julie Leca YOU? Author Swipe

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Mutant <i>IDH1</i> cooperates with <i>NPM1c</i> or <i>FLT3</i> <sup>ITD</sup> to drive distinct myeloid diseases and molecular outcomes Open

Tetsunori Sakamoto, Julie Leca, Xin Zhang, Cem Meydan, Jonathan Foox , et al. · 2025

In human acute myeloid leukemia (AML), mutations of isocitrate dehydrogenase-1 ( IDH1 ) often co-occur with NPM1 mutations, and less frequently with FLT3 mutations. To investigate whether the effects of IDH1 mutation differ according to th…

Figure S1 from LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker Open

Christian Bressy, Sophie Lac, Jérémy Nigri, Julie Leca, Julie Roques , et al. · 2023

Measurement of LIF mRNA level in normal and tumoral human fibroblasts by RT-QPCRs.

Figure S2 from LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker Open

Christian Bressy, Sophie Lac, Jérémy Nigri, Julie Leca, Julie Roques , et al. · 2023

Schematic representation of experimental protocols for (A) the co-culture method in order to produce specific conditioned media used in following migration assay or ELISA tittering as for (B) the migration assay method for the measurement …

Data from LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker Open

Christian Bressy, Sophie Lac, Jérémy Nigri, Julie Leca, Julie Roques , et al. · 2023

Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive stroma and pathogenic modifications to the peripheral nervous system that elevate metastatic capacity. In this study, we show that the IL6-related stem cell–promoting fa…

Figure S1 from LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker Open

Christian Bressy, Sophie Lac, Jérémy Nigri, Julie Leca, Julie Roques , et al. · 2023

Measurement of LIF mRNA level in normal and tumoral human fibroblasts by RT-QPCRs.

Figure S4 from LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker Open

Christian Bressy, Sophie Lac, Jérémy Nigri, Julie Leca, Julie Roques , et al. · 2023

We analyzed the impact of LIF (A) or conditioned media (B) on sNF96.2 cell survival using caspase-3 positive cell measurement.

Figure S4 from LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker Open

Christian Bressy, Sophie Lac, Jérémy Nigri, Julie Leca, Julie Roques , et al. · 2023

We analyzed the impact of LIF (A) or conditioned media (B) on sNF96.2 cell survival using caspase-3 positive cell measurement.

Figure S2 from LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker Open

Christian Bressy, Sophie Lac, Jérémy Nigri, Julie Leca, Julie Roques , et al. · 2023

Schematic representation of experimental protocols for (A) the co-culture method in order to produce specific conditioned media used in following migration assay or ELISA tittering as for (B) the migration assay method for the measurement …

Data from LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker Open

Christian Bressy, Sophie Lac, Jérémy Nigri, Julie Leca, Julie Roques , et al. · 2023

Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive stroma and pathogenic modifications to the peripheral nervous system that elevate metastatic capacity. In this study, we show that the IL6-related stem cell–promoting fa…

Figure S3 from LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker Open

Christian Bressy, Sophie Lac, Jérémy Nigri, Julie Leca, Julie Roques , et al. · 2023

Amalysis of Akt/Stat3 signaling induction following LIF stimulation. We measured the induction of STAT3 (A) and Akt (B) phosphorylation by western blot in sNF96.2 after incubation with LIF recombinant protein. We confirmed the specificity …

Figure S3 from LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker Open

Christian Bressy, Sophie Lac, Jérémy Nigri, Julie Leca, Julie Roques , et al. · 2023

Amalysis of Akt/Stat3 signaling induction following LIF stimulation. We measured the induction of STAT3 (A) and Akt (B) phosphorylation by western blot in sNF96.2 after incubation with LIF recombinant protein. We confirmed the specificity …

Figure S5 from LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker Open

Christian Bressy, Sophie Lac, Jérémy Nigri, Julie Leca, Julie Roques , et al. · 2023

Measurement of Schwann cell differentiation through JAK/STAT pathway following LIF induction. The staining of 2 differentiation markers (S100 and Pou3F2) were validated in human PDA samples (A) then used on sNF96.2 cells following conditio…

Supplementary data from LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker Open

Christian Bressy, Sophie Lac, Jérémy Nigri, Julie Leca, Julie Roques , et al. · 2023

Supplementary methods and Figure legends

Figure S5 from LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker Open

Christian Bressy, Sophie Lac, Jérémy Nigri, Julie Leca, Julie Roques , et al. · 2023

Measurement of Schwann cell differentiation through JAK/STAT pathway following LIF induction. The staining of 2 differentiation markers (S100 and Pou3F2) were validated in human PDA samples (A) then used on sNF96.2 cells following conditio…

Supplementary data from LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker Open

Christian Bressy, Sophie Lac, Jérémy Nigri, Julie Leca, Julie Roques , et al. · 2023

Supplementary methods and Figure legends

IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment Open

Julie Leca, François Lemonnier, Cem Meydan, Jonathan Foox, Samah El Ghamrasni , et al. · 2023

Distinct and opposite effects of leukemogenic <i>Idh</i> and <i>Tet2</i> mutations in hematopoietic stem and progenitor cells Open

Jérôme Fortin, Ming-Feng Chiang, Cem Meydan, Jonathan Foox, Parameswaran Ramachandran , et al. · 2023

Mutations in IDH1, IDH2 , and TET2 are recurrently observed in myeloid neoplasms. IDH1 and IDH2 encode isocitrate dehydrogenase isoforms, which normally catalyze the conversion of isocitrate to α-ketoglutarate (α-KG). Oncogenic IDH1/2 muta…

Ketogenic HMG‐CoA lyase and its product β‐hydroxybutyrate promote pancreatic cancer progression Open

Victoire Gouirand, Tristan Gicquel, Evan C. Lien, Emilie Jaune, Quentin Da Costa , et al. · 2022

<i>IDH1</i> mutation contributes to myeloid dysplasia in mice by disturbing heme biosynthesis and erythropoiesis Open

Yu Gu, Risheng Yang, Ying Yang, Yuanlin Zhao, Andrew Wakeham , et al. · 2020

Isocitrate dehydrogenase (IDH) mutations are common genetic alterations in myeloid disorders, including acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Epigenetic changes, including abnormal histone and DNA methylation, ha…

Parasitic Behavior of Leukemic Cells in Systemic Host Metabolism Open

Julie Leca, Thorsten Berger, Tak W. Mak · 2018

LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker Open

Christian Bressy, Sophie Lac, Jérémy Nigri, Julie Leca, Julie Roques , et al. · 2017

Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive stroma and pathogenic modifications to the peripheral nervous system that elevate metastatic capacity. In this study, we show that the IL6-related stem cell–promoting fa…

Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness Open

Julie Leca, Sébastien Martinez, Sophie Lac, Jérémy Nigri, Véronique Secq , et al. · 2016

The intratumoral microenvironment, or stroma, is of major importance in the pathobiology of pancreatic ductal adenocarcinoma (PDA), and specific conditions in the stroma may promote increased cancer aggressiveness. We hypothesized that thi…

TAp73 loss favors Smad-independent TGF-β signaling that drives EMT in pancreatic ductal adenocarcinoma Open

A K Thakur, Jérémy Nigri, Sophie Lac, Julie Leca, Christian Bressy , et al. · 2016

Stromal SLIT2 impacts on pancreatic cancer-associated neural remodeling Open

Véronique Secq, Julie Leca, Christian Bressy, Fabienne Guillaumond, P Skrobuk , et al. · 2015

Pancreatic ductal adenocarcinoma (PDA) is a critical health issue in the field of cancer, with few therapeutic options. Evidence supports an implication of the intratumoral microenvironment (stroma) on PDA progression. However, its contrib…

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