Julie Loebach Wetherell
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View article: Considering culture to optimise psychosocial treatments for caregivers of persons with Alzheimer's disease and related dementias
Considering culture to optimise psychosocial treatments for caregivers of persons with Alzheimer's disease and related dementias Open
View article: Brain resting state functional connectivity changes with aerobic exercise, and mindfulness: A narrative review
Brain resting state functional connectivity changes with aerobic exercise, and mindfulness: A narrative review Open
View article: The Senescence Associated Secretory Phenotype, a key marker of cellular senescence, is elevated in depression and moderated by sex
The Senescence Associated Secretory Phenotype, a key marker of cellular senescence, is elevated in depression and moderated by sex Open
In older adults, sex plays a significant role in senescence-related changes in depression. A higher senescence burden in males with depression may be an indicator of greater vulnerability to accelerated biological aging and a marker of ele…
View article: Brief Video-Delivered Intervention to Reduce Anxiety and Improve Functioning in Older Veterans: Pilot Randomized Controlled Trial
Brief Video-Delivered Intervention to Reduce Anxiety and Improve Functioning in Older Veterans: Pilot Randomized Controlled Trial Open
Background Older veterans with anxiety disorders encounter multiple barriers to receiving mental health services, including transportation difficulties, physical limitations, and limited access to providers trained to work with older perso…
View article: Cardiovascular Fitness and Sleep, but not Physical Activity, are Associated with Improved Brain Functional Connectivity in Older Adults.
Cardiovascular Fitness and Sleep, but not Physical Activity, are Associated with Improved Brain Functional Connectivity in Older Adults. Open
Background Aging results in changes in resting state functional connectivity within key networks associated with cognition. Cardiovascular function, physical activity, sleep, and body composition may influence these age-related changes in …
View article: Sex differences in plasma proteomic markers in late-life depression
Sex differences in plasma proteomic markers in late-life depression Open
View article: Fatness but Not Fitness Linked to BrainAge: Longitudinal Changes in Brain Aging during an Exercise Intervention
Fatness but Not Fitness Linked to BrainAge: Longitudinal Changes in Brain Aging during an Exercise Intervention Open
Purpose Fitness, physical activity, body composition, and sleep have all been proposed to explain differences in brain health. We hypothesized that an exercise intervention would result in improved fitness and body composition and would be…
View article: Relationship between baseline plasma p‐tau181 and longitudinal changes in cognition and structural brain measures in a cohort of cognitively unimpaired older adults
Relationship between baseline plasma p‐tau181 and longitudinal changes in cognition and structural brain measures in a cohort of cognitively unimpaired older adults Open
INTRODUCTION Preclinical Alzheimer's disease (AD) affects a significant proportion of cognitively unimpaired (CU) older adults. Currently, blood‐based biomarkers detect very early changes in the AD continuum with great accuracy. METHODS We…
View article: Data-efficient resting-state functional magnetic resonance imaging brain mapping with deep learning
Data-efficient resting-state functional magnetic resonance imaging brain mapping with deep learning Open
OBJECTIVE Resting-state functional MRI (RS-fMRI) enables the mapping of function within the brain and is emerging as an efficient tool for the presurgical evaluation of eloquent cortex. Models capable of reliable and precise mapping of res…
View article: Associations of Lean Mass, Muscular Strength, and Physical Function with Trabecular Bone Score in Older Adults
Associations of Lean Mass, Muscular Strength, and Physical Function with Trabecular Bone Score in Older Adults Open
View article: Beyond maintaining safety: Examining the benefit of emotion-centered problem solving therapy added to safety planning for reducing late life suicide risk
Beyond maintaining safety: Examining the benefit of emotion-centered problem solving therapy added to safety planning for reducing late life suicide risk Open
View article: Effects of Mindfulness Training and Exercise on Cognitive Function in Older Adults
Effects of Mindfulness Training and Exercise on Cognitive Function in Older Adults Open
Importance Episodic memory and executive function are essential aspects of cognitive functioning that decline with aging. This decline may be ameliorable with lifestyle interventions. Objective To determine whether mindfulness-based stress…
View article: Home-based primary care–mental health integration in the Veterans Health Administration: An updated evaluation of practice patterns.
Home-based primary care–mental health integration in the Veterans Health Administration: An updated evaluation of practice patterns. Open
Starting in 2008, the U.S. Veterans Health Administration required the integration of mental health providers (MH providers) in Home-Based Primary Care (HBPC) programs to promote access to and quality of mental health services for veterans…
View article: Late-Life Depression is Associated With Increased Levels of GDF-15, a Pro-Aging Mitokine
Late-Life Depression is Associated With Increased Levels of GDF-15, a Pro-Aging Mitokine Open
View article: Covariance and Correlation Analysis of Resting State Functional Magnetic Resonance Imaging Data Acquired in a Clinical Trial of Mindfulness-Based Stress Reduction and Exercise in Older Individuals
Covariance and Correlation Analysis of Resting State Functional Magnetic Resonance Imaging Data Acquired in a Clinical Trial of Mindfulness-Based Stress Reduction and Exercise in Older Individuals Open
We describe and apply novel methodology for whole-brain analysis of resting state fMRI functional connectivity data, combining conventional multi-channel Pearson correlation with covariance analysis. Unlike correlation, covariance analysis…
View article: Brief Video-Delivered Interventions to Reduce Anxiety in Older Veterans: A Pilot RCT
Brief Video-Delivered Interventions to Reduce Anxiety in Older Veterans: A Pilot RCT Open
Older Veterans with anxiety disorders encounter barriers to receiving mental health services that may be overcome by using brief technology-delivered interventions. To address this, we conducted a pilot randomized controlled trial (RCT) co…
View article: VA Problem-Solving Training During COVID-19 for Clinicians of Patients With Complex Comorbidities
VA Problem-Solving Training During COVID-19 for Clinicians of Patients With Complex Comorbidities Open
To address the shortage of mental health providers in geriatrics, VA has implemented clinician training in a VA Problem Solving Training (PST) protocol adapted to the needs of mostly older patients with complex comorbidities. This presenta…
View article: Acceptance and commitment therapy for older people with treatment-resistant generalised anxiety disorder: the FACTOID feasibility study
Acceptance and commitment therapy for older people with treatment-resistant generalised anxiety disorder: the FACTOID feasibility study Open
Background Generalised anxiety disorder, characterised by excessive anxiety and worry, is the most common anxiety disorder among older people. It is a condition that may persist for decades and is associated with numerous negative outcomes…
View article: Evidence-based assessment of treatment outcomes for late-life generalized anxiety disorder using the Penn State Worry Questionnaire (PSWQ) and Penn State Worry Questionnaire – Abbreviated (PSWQ-A)
Evidence-based assessment of treatment outcomes for late-life generalized anxiety disorder using the Penn State Worry Questionnaire (PSWQ) and Penn State Worry Questionnaire – Abbreviated (PSWQ-A) Open
Findings suggest that most of the previously used definitions have underestimated the treatment effects for late-life GAD. However overall, the PSWQ and PSWQ-A are suboptimal for assessing treatment outcome for late-life GAD. The standardi…
View article: Acceptance and commitment therapy for late-life treatment-resistant generalised anxiety disorder: a feasibility study
Acceptance and commitment therapy for late-life treatment-resistant generalised anxiety disorder: a feasibility study Open
Background Generalised anxiety disorder (GAD) is the most common anxiety disorder in older people. First-line management includes pharmacological and psychological therapies, but many do not find these effective or acceptable. Little is kn…
View article: Problem-solving training for Veterans in home based primary care: an evaluation of intervention effectiveness
Problem-solving training for Veterans in home based primary care: an evaluation of intervention effectiveness Open
Preliminary findings support the continued dissemination and implementation of this brief PST intervention for HBPC Veterans, and its potential for use with non-VA home care populations with complex comorbidities.
View article: Development of a Suicide Prevention Toolkit for VA Home-Based Primary Care Teams
Development of a Suicide Prevention Toolkit for VA Home-Based Primary Care Teams Open
The U.S. Department of Veterans Affairs Home-Based Primary Care program (HBPC) serves Veterans with multiple comorbid physical and psychological conditions that can increase suicide risk. HBPC teams are uniquely able to implement suicide r…
View article: The Association between Age and Experienced Emotions in Hoarding Disorder
The Association between Age and Experienced Emotions in Hoarding Disorder Open
Objectives: Hoarding disorder (HD) is conceptualized as a fear-based disorder and exposure to sorting/discarding possessions is a core part of treatment. However, there has been no investigation of age-related differences in emotion…
View article: A Qualitative study of older adults’ perspectives on initiating exercise and mindfulness practice
A Qualitative study of older adults’ perspectives on initiating exercise and mindfulness practice Open
Background: Mindfulness practice and exercise are ways by which older adults can improve and maintain their physical, emotional and cognitive health. Methods: This single-site qualitative study gathered insights of older adults’ perception…
View article: A qualitative study of older adults’ perspectives on initiating exercise and mindfulness practice
A qualitative study of older adults’ perspectives on initiating exercise and mindfulness practice Open
View article: A Qualitative study of older adults’ perspectives on initiating exercise and mindfulness practice
A Qualitative study of older adults’ perspectives on initiating exercise and mindfulness practice Open
Background: Mindfulness practice and exercise are ways by which older adults can improve and maintain their physical, emotional and cognitive health. Methods: This single-site qualitative study gathered insights of older adults’ perception…
View article: Comorbid anxiety in late‐life depression: Relationship with remission and suicidal ideation on venlafaxine treatment
Comorbid anxiety in late‐life depression: Relationship with remission and suicidal ideation on venlafaxine treatment Open
In older adults with MDD, comorbid anxiety symptoms are associated with symptom severity but do not affect antidepressant remission or time to remission.
View article: MECHANISM OF ACTION: AGE DIFFERENCES IN RESPONSE TO ACCEPTANCE AND COMMITMENT THERAPY FOR CHRONIC PAIN
MECHANISM OF ACTION: AGE DIFFERENCES IN RESPONSE TO ACCEPTANCE AND COMMITMENT THERAPY FOR CHRONIC PAIN Open
A recent randomized comparison of Acceptance and Commitment Therapy (ACT) vs. Cognitive-Behavioral Therapy for chronic pain found a clear age interaction effect, such that older adults benefitted more from ACT. In a subsequent study compar…
View article: “Little things do not get to me anymore”: a qualitative study of older adults’ perspectives on initiating exercise and mindfulness practice
“Little things do not get to me anymore”: a qualitative study of older adults’ perspectives on initiating exercise and mindfulness practice Open
Background: Mindfulness practice and exercise are ways by which older adults can improve and maintain their physical, emotional and cognitive health. Methods: This single-site qualitative study gathered insights of older adults’ perception…
View article: Acceptance and commitment therapy as an adjunct to the <i>MOVE!</i> programme: a randomized controlled trial
Acceptance and commitment therapy as an adjunct to the <i>MOVE!</i> programme: a randomized controlled trial Open
Summary Objective The current study tested the efficacy of an acceptance and commitment therapy (ACT) group intervention for disinhibited eating behaviour as an adjunct to the Veterans Affairs MOVE!© weight management programme. Methods Ve…