Julie Mazzolini
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View article: Enabling mechanistic studies of EVs in vivo: a protocol for isolation and cell-specific labelling in larval zebrafish
Enabling mechanistic studies of EVs in vivo: a protocol for isolation and cell-specific labelling in larval zebrafish Open
Background Extracellular vesicles (EVs) are critical mediators of intercellular communication in development, physiology, and disease. In vivo models such as Drosophila melanogaster , Caenorhabditis elegans , and Danio rerio (zebrafish) no…
View article: Wasl is crucial to maintain microglial core activities during glioblastoma initiation stages
Wasl is crucial to maintain microglial core activities during glioblastoma initiation stages Open
Microglia actively promotes the growth of high‐grade gliomas. Within the glioma microenvironment an amoeboid microglial morphology has been observed, however the underlying causes and the related impact on microglia functions and their tum…
View article: Wasl is crucial to maintain microglial core activities during glioblastoma initiation stages
Wasl is crucial to maintain microglial core activities during glioblastoma initiation stages Open
Summary Microglia actively promote the growth of high-grade gliomas. Within the glioma microenvironment an activated (amoeboid) microglial morphology has been observed, however the underlying causes and the related impact on microglia func…
View article: Environmentally Relevant Iron Oxide Nanoparticles Produce Limited Acute Pulmonary Effects in Rats at Realistic Exposure Levels
Environmentally Relevant Iron Oxide Nanoparticles Produce Limited Acute Pulmonary Effects in Rats at Realistic Exposure Levels Open
Iron is typically the dominant metal in the ultrafine fraction of airborne particulate matter. Various studies have investigated the toxicity of inhaled nano-sized iron oxide particles (FeOxNPs) but their results have been contradictory, w…
View article: Gene expression profiling reveals a conserved microglia signature in larval zebrafish
Gene expression profiling reveals a conserved microglia signature in larval zebrafish Open
Microglia are the resident macrophages of the brain. Over the past decade, our understanding of the function of these cells has significantly improved. Microglia do not only play important roles in the healthy brain but are involved in alm…
View article: Brain tumours repurpose endogenous neuron to microglia signalling mechanisms to promote their own proliferation
Brain tumours repurpose endogenous neuron to microglia signalling mechanisms to promote their own proliferation Open
Previously we described direct cellular interactions between microglia and AKT1+ brain tumour cells in zebrafish (Chia et al., 2018). However, it was unclear how these interactions were initiated: it was also not clear if they had an impac…
View article: Isolation and RNA Extraction of Neurons, Macrophages and Microglia from Larval Zebrafish Brains
Isolation and RNA Extraction of Neurons, Macrophages and Microglia from Larval Zebrafish Brains Open
To gain a detailed understanding of the role of different CNS cells during development or the establishment and progression of brain pathologies, it is important to isolate these cells without changing their gene expression profile. The ze…
View article: Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain
Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain Open
It is now clear that microglia and macrophages are present in brain tumors, but whether or how they affect initiation and development of tumors is not known. Exploiting the advantages of the zebrafish (Danio rerio) model, we showed that ma…
View article: Author response: Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain
Author response: Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract It is now clear that microglia and macrophages …
View article: A zebrafish live imaging model to study microglia-glioma interactions
A zebrafish live imaging model to study microglia-glioma interactions Open
Glioblastoma multiforme is the most common and deadliest form of brain cancer. Gliomas are highly infiltrated by microglia and macrophages, which have been shown to promote tumour growth and invasion. However, due to limitations of existin…
View article: "Phagosome Closure Assay" to Visualize Phagosome Formation in Three Dimensions Using Total Internal Reflection Fluorescent Microscopy (TIRFM)
"Phagosome Closure Assay" to Visualize Phagosome Formation in Three Dimensions Using Total Internal Reflection Fluorescent Microscopy (TIRFM) Open
Phagocytosis is a mechanism used by specialized cells to internalize and eliminate microorganisms or cellular debris. It relies on profound rearrangements of the actin cytoskeleton that is the driving force for plasma membrane extension ar…
View article: Dynamin‐Actin Cross Talk Contributes to Phagosome Formation and Closure
Dynamin‐Actin Cross Talk Contributes to Phagosome Formation and Closure Open
Phagocytosis is a mechanism used by macrophages to internalize and eliminate microorganisms or cellular debris. It relies on profound rearrangements of the actin cytoskeleton that is the driving force allowing plasma membrane extension aro…