Julien Bobe
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Identifying Sexually Dimorphic Circulating MicroRNAs in Gonochoristic and Hermaphroditic Marine Fish Species Open
In many fish species, males and females are difficult to distinguish at the juvenile stage and size differences appear during maturation, often favoring females. Molecular tools for sexing live fish would benefit aquaculture, fisheries, an…
Inter-individual gene expression variability implies stable regulation of brain-biased genes across organs Open
Phenotypic variation among individuals plays a key role in evolution, since variation provides the material on which natural selection can act. One important link between genetic and phenotypic variation is gene expression. As for other ph…
Identifying sexually dimorphic circulating microRNAs in gonochoristic and hermaphroditic marine fish species Open
In many fish species, males and females are hard to distinguish at the juvenile stage and size differences appear during maturation, often favoring females. Molecular tools for sexing live fish would benefit aquaculture, fisheries, and con…
Evolutionarily conserved ovarian fluid proteins are responsible for extending egg viability in salmonid fish Open
In contrast to most fishes, salmonids exhibit the unique ability to hold their eggs for several days after ovulation without significant loss of viability. During this period, eggs are held in the body cavity in a biological fluid, the coe…
View article: Autism-related gene intergenerationally regulates neurodevelopment and behavior in fish through non-genetic mechanisms
Autism-related gene intergenerationally regulates neurodevelopment and behavior in fish through non-genetic mechanisms Open
Parental stress can impact progeny neurodevelopment and long-term behavior through gamete-mediated non-genetic inheritance ( i.e., by mechanisms that do not involve transmission of genetic alleles). While intergenerational effects have bee…
Identification of sex-biased miRNA markers informative of heat-past events Open
Elevated temperatures during early developmental stages play a pivotal role in the fate of the final sexual phenotype of fish populations, particularly towards male-skewed sex ratios. This is the case with European sea bass ( Dicentrarchus…
View article: Looking for a needle in a haystack: de novo phenotypic target identification reveals Hippo pathway-mediated miR-202 regulation of egg production
Looking for a needle in a haystack: de novo phenotypic target identification reveals Hippo pathway-mediated miR-202 regulation of egg production Open
Understanding microRNA (miRNA) functions has been hampered by major difficulties in identifying their biological target(s). Currently, the main limitation is the lack of a suitable strategy to identify biologically relevant targets among a…
View article: Looking for a needle in a haystack: de novo phenotypic target identification reveals Hippo pathway-mediated miR-202 regulation of egg production
Looking for a needle in a haystack: de novo phenotypic target identification reveals Hippo pathway-mediated miR-202 regulation of egg production Open
Understanding microRNA (miRNA) functions has been hampered by major difficulties in identifying their biological target(s). Currently, the main limitation is the lack of a suitable strategy to identify biologically relevant targets among a…
Evolutionarily conserved ovarian fluid proteins are responsible for extending egg viability in salmonid fish Open
In contrast to most fish species, salmonids exhibit the unique ability to hold their eggs for several days after ovulation without significant loss of viability. During this period, eggs are held in the body cavity in a biological fluid, t…
Genomic disruption of type II vitellogenin leads to vitellin membrane deficiencies and significant mortalities at early stages of embryonic development in zebrafish (<i>Danio rerio</i>) Open
Type II vitellogenin (Vtg2), the second most abundant type of vitellogenin in zebrafish eggs, is a major source of nutrients for early embryonic development. The main objective of this study was to determine the specific functions and esse…
Circulating MicroRNAs indicative of sex and stress in the European seabass (<i>Dicentrarchus labrax</i>): toward the identification of new biomarkers Open
MicroRNAs (miRNAs) constitute a new category of biomarkers. Studies on miRNAs in non-mammalian species have drastically increased in the last few years. Here, we explored the use of miRNAs as potential, poorly-invasive markers, to identify…
View article: Quantitative analysis of asynchronous oogenesis dynamics in fish: Application of a modern 3D analysis approach to an old problem
Quantitative analysis of asynchronous oogenesis dynamics in fish: Application of a modern 3D analysis approach to an old problem Open
International audience
View article: Maternal auts2a contribution is a major intergenerational driver of neurodevelopment and behavior
Maternal auts2a contribution is a major intergenerational driver of neurodevelopment and behavior Open
AUTS2 gene has been associated with numerous human pathologies including autism. The respective importance of its maternal and paternal contribution remains however unknown. Here we show using a vertebrate model that the lack of maternal, …
View article: Yeast extract improves growth in rainbow trout (<i>Oncorhynchus mykiss</i>) fed a fishmeal-free diet and modulates the hepatic and distal intestine transcriptomic profile
Yeast extract improves growth in rainbow trout (<i>Oncorhynchus mykiss</i>) fed a fishmeal-free diet and modulates the hepatic and distal intestine transcriptomic profile Open
Replacing fishmeal with alternative protein sources and improving new ingredients diets with feed additives are major objectives in aquaculture. The aim of this study was to evaluate benefits for rainbow trout ( Oncorhynchus mykiss ) of su…
View article: Genome structures resolve the early diversification of teleost fishes
Genome structures resolve the early diversification of teleost fishes Open
Accurate species phylogenies are a prerequisite for all evolutionary research. Teleosts are the largest and most diversified group of extant vertebrates, but relationships among their three oldest extant lineages remain unresolved. On the …
View article: Inter-individual variability filter
Inter-individual variability filter Open
Script, data and results to analyze inter-individual variability in WT and KO individuals for Janati-Idrissi et al 2023.
Deciphering sex-specific miRNAs as heat-recorders in zebrafish Open
In the last decade, a plethora of microRNAs (miRNAs) has been reported in a wide variety of physiological processes, including reproduction, in many aquatic organisms. However, miRNAome alterations occurred by environmental cues due to wat…
auts2 Features and Expression Are Highly Conserved during Evolution Despite Different Evolutionary Fates Following Whole Genome Duplication Open
The AUTS2 gene plays major roles during brain development and is associated with various neuropathologies including autism. Data in non-mammalian species are scarce, and the aim of our study was to provide a comprehensive analysis of auts2…
Physical Enrichment Triggers Brain Plasticity and Influences Blood Plasma Circulating miRNA in Rainbow Trout (Oncorhynchus mykiss) Open
Physical enrichment is known to improve living conditions of fish held in farming systems and has been shown to promote behavioral plasticity in captive fish. However, the brain’s regulatory-mechanism systems underlying its behavioral effe…