Explanipedia

Ischemia-reperfusion injury with a model of porcine whole-blood ex-vivo lung perfusion Open

Jean-Baptiste Ménager, Julia Mercier, Justin Issard, Maria-Rosa Ghigna, Jeanne Tran Van Nhieu , et al. · 2025

Introduction Our objective was to model Ischemia-Reperfusion (IR) injuries by ex-vivo perfusion of porcine lungs with whole blood containing the inflammatory cells. Methods Lungs and whole blood were collected from 12 pigs and submitted to…

Ca <sup>2+</sup> Cycling Alteration in a Porcine Model of Right Ventricular Dysfunction Open

Fabrice Antigny, Rui Luo, Romain Perrier, Bastien Masson, Guillaume Fadel , et al. · 2025

BACKGROUND: Pulmonary hypertension is a severe disease with high mortality rates due to right ventricular (RV) failure. The molecular and cellular processes involved in RV remodeling, including Ca 2+ handling, remain elusive due to the lac…

Contribution of cardiac surgeons in transcatheter aortic valve replacement activity in France Open

Gabriel Saiydoun, Saadé Saadé, Chadi Aludaat, Chloé Bernard, Guillaume Lebreton , et al. · 2025

OBJECTIVES This study provides a thorough analysis of cardiac surgeons' involvement in transcatheter aortic valve replacement (TAVR) activities in France, covering decision-making, procedural roles, training, and outcome analysis. METHODS …

Intimal cardiac sarcoma Open

Sylvain Diop, Vincent de Montpréville, Julien Guihaire · 2024

Association between pulmonary artery pulsatility and mortality after implantation of left ventricular assist device Open

Ali Akamkam, Vincent Galand, Marie Jungling, Clément Delmas, Camille Dambrin , et al. · 2024

Aims Right ventricular failure after left ventricular assist device (LVAD) implantation is a major concern that remains challenging to predict. We sought to investigate the relationship between preoperative pulmonary artery pulsatility ind…

Healthcare-associated infections in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study Open

Nicolas Nesseler, Alexandre Mansour, Matthieu Schmidt, Marylou Para, Alizée Porto , et al. · 2024

Doppler echocardiography for surveillance of acute cardiac allograft rejection: a 28-year single-center experience Open

Aurelien Vallée, Lucile Houyel, Ngoc Minh To, Audrey Fels, Martin Kloëckner , et al. · 2024

Doppler echocardiography as a first-line method for surveillance of ACR did not impair long-term results after HT. These findings suggest that this non-invasive approach might be a reasonable alternative to systematic EMB, limiting risk an…

Heart graft preservation technics and limits: an update and perspectives Open

Aurore Ughetto, François Roubille, Adrien Molina, Pascal Battistella, Philippe Gaudard , et al. · 2023

Heart transplantation, the gold standard treatment for end-stage heart failure, is limited by heart graft shortage, justifying expansion of the donor pool. Currently, static cold storage (SCS) of hearts from donations after brainstem death…

Diuretic dose is a strong prognostic factor in ambulatory patients awaiting heart transplantation Open

Guillaume Baudry, Guillaume Coutance, Richard Dorent, Fabrice Bauer, Katrien Blanchart , et al. · 2023

Aims The prognostic value of ‘high dose’ loop diuretics in advanced heart failure outpatients is unclear. We aimed to assess the prognosis associated with loop diuretic dose in ambulatory patients awaiting heart transplantation (HT). Metho…

Pulmonary hypertension without heart failure causes cardiorenal syndrome in a porcine model Open

Arthur Orieux, Chloé Samson, Laurence Piéroni, Sarah Drouin, Simon Dang Van , et al. · 2023

Cardiorenal syndromes type 1 and 2 are complex disorders in which cardiac dysfunction leads to kidney dysfunction. However, the mechanisms remain incompletely explained, during pulmonary hypertension in particular. The objective of this st…

Imaging the vasculature of a beating heart by dynamic speckle: the challenge of a quasiperiodic motion Open

Aurélien Plyer, Elise Colin‐Koeniguer, Xavier Orlik, Ali Akamkam, Julien Guihaire · 2023

The spatial and temporal evolution of the field backscattered by a beating heart while illuminated with a coherent light reveals its macro- and microvascularization in real time. To perform these vascularization images, we use a recently p…

Issue Information Open

Rohini Samudralwar, Amanda Jagolino‐Cole, Adeline Goss, Karen S. Rommelfanger, Cloé Payet , et al. · 2023

Wiley is a founding member of the UN-backed HINARI, AGORA, and OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries.

Systematic Review on In Situ Laser Fenestrated Repair for the Endovascular Management of Aortic Arch Pathologies Open

Thomas Le Houérou, Petroula Nana, Mathieu Pernot, Julien Guihaire, Antoine Gaudin , et al. · 2023

Background: In situ laser-fenestrated thoracic aortic endovascular repair (FTEVAR) has emerged as a valuable alternative for aortic arch management. This review assessed the early and follow-up outcomes of in situ laser-FTEVAR in aortic ar…

Single-cell mass cytometry on peripheral cells in Myasthenia Gravis identifies dysregulation of innate immune cells Open

Julien Verdier, Odessa‐Maud Fayet, Edouard Hemery, Frédérique Truffault, Natalia Pinzón , et al. · 2023

Myasthenia Gravis (MG) is a neurological autoimmune disease characterized by disabling muscle weaknesses due to anti-acetylcholine receptor (AChR) autoantibodies. To gain insight into immune dysregulation underlying early-onset AChR + MG, …

Central Role of Macrophages and Nucleic Acid Release in Myasthenia Gravis Thymus Open

Cloé Payet, Axel You, Odessa‐Maud Fayet, Edouard Hemery, Frédérique Truffault , et al. · 2022

Objective Myasthenia gravis (MG) is a neuromuscular disease mediated by antibodies against the acetylcholine receptor (AChR). The thymus plays a primary role in AChR‐MG and is characterized by a type I interferon (IFN) signature linked to …

Design and analysis of a Circulatory Assistance Benchmark Actuator for an Artificial Lung Open

Abdelhakim Sahnoune, Maya Hage-Hassan, G. Krebs, Claude Marchand, Julien Guihaire , et al. · 2022

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Bleeding and thrombotic events in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study Open

Alexandre Mansour, Erwan Flécher, Matthieu Schmidt, Bertrand Rozec, Isabelle Gouin‐Thibault , et al. · 2022

Prognosis value of Forrester's classification in advanced heart failure patients awaiting heart transplantation Open

Guillaume Baudry, Guillaume Coutance, Richard Dorent, Fabrice Bauer, Katrien Blanchart , et al. · 2022

Aims The value of Forrester's perfusion/congestion profiles assessed by invasive catheter evaluation in non‐inotrope advanced heart failure patients listed for heart transplant (HT) is unclear. We aimed to assess the value of haemodynamic …

Epinephrine infusion during venoarterial extracorporeal membrane oxygenation support for cardiogenic shock: simply inefficient or deleterious? Open

Julien Guihaire, Simon Dang Van · 2022

International audience

Off-Pump Wrapping for Acute Type A Aortic Dissection: Alternate Option in Patients Deemed Inoperable Open

Julien Guihaire, Ramzi Ramadan, R Nottin · 2022

Machine preservation and ex situ assessment of the donor heart: a new paradigm in heart transplantation Open

Julien Guihaire, S. Linthout van, Dorothee Brunet, Ali Akamkam, Maïra Gaillard , et al. · 2022

Heart transplantation is the gold standard treatment for advanced heart failure in selected patients. Organ shortage is however a major concern, leading transplant teams to expand the criteria for donor selection. Organ retrieval is routin…

A patient-specific proof of concept with a three-dimensionally printed model before performing an endovascular Bentall procedure Open

Aurelien Vallée, Julien Guihaire, Saïd Ghostine, Dominque Fabre, Stéphan Haulon · 2021

Conception d'un actionneur d'assistance circulatoire Open

Abdelhakim Sahnoune, Maya Hage-Hassan, G. Krebs, Philippe Dessante, Claude Marchand , et al. · 2021

International audience

Conception d'un actionneur d'assitance circulatoire Open

Abdelhakim Sahnoune, Maya Hage-Hassan, G. Krebs, Philippe Dessante, Claude Marchand , et al. · 2021

First symptoms and health care pathways in hospitalized patients with acute heart failure: <span>ICPS2</span> survey. A report from the Heart Failure Working Group (GICC) of the French Society of Cardiology Open

Florence Beauvais, Lamia Tartière, Théo Pezel, Chloé Motet, Marie‐Claude Aumont , et al. · 2021

Background Acute heart failure (AHF) is a common serious condition that contributes to about 5% of all emergency hospital admissions in Europe. Hypothesis To assess the type and chronology of the first AHF symptoms before hospitalization a…

Extracorporeal membrane oxygenation network organisation and clinical outcomes during the COVID-19 pandemic in Greater Paris, France: a multicentre cohort study Open

Guillaume Lebreton, Matthieu Schmidt, Maharajah Ponnaiah, Thierry Folliguet, Marylou Para , et al. · 2021

Supra-annular aortic valve replacement: technique and early outcomes Open

Nathanael Shraer, Ramzi Ramadan, Alexandre Azmoun, Julien Guihaire · 2021

OBJECTIVES: The supra-annular aortic valve replacement (SA-AVR) allows for implantation of larger prostheses. We describe the technique, early post-operative outcomes and hospital mortality. METHODS: Patients who underwent SA-AVR with the …

Congestive pulmonary oedema during venoarterial extracorporeal membrane oxygenation support: a plea for balloon atrial septostomy Open

Martin Kloëckner, Julien Guihaire, Sébastien Hascoët · 2021

A compact integrated microfluidic oxygenator with high gas exchange efficiency and compatibility for long-lasting endothelialization Open

Julie Lachaux, Gilgueng Hwang, Nassim Arouche, Sina Naserian, Abdelmounaïm Harouri , et al. · 2021

A novel microfluidic architecture allowing simple parallel stacking of the different 4 inch circular units of curved blood capillaries covering a maximal surface area with high compacity is proposed for blood oxygenation at high flow rate.

Targeted proteomics of right heart adaptation to pulmonary arterial hypertension Open

Myriam Amsallem, Andrew J. Sweatt, Jennifer Arthur Ataam, Julien Guihaire, Florence Lecerf , et al. · 2020

No prior proteomic screening study has centred on the right ventricle (RV) in pulmonary arterial hypertension (PAH). This study investigates the circulating proteomic profile associated with right heart maladaptive phenotype (RHMP) in PAH.…

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