Julien Marquevielle
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View article: The diversity of splicing modifiers acting on A-1 bulged 5′-splice sites reveals rules for rational drug design
The diversity of splicing modifiers acting on A-1 bulged 5′-splice sites reveals rules for rational drug design Open
Pharmacological modulation of RNA splicing by small molecules is an emerging facet of drug discovery. In this context, the SMN2 splicing modifier SMN-C5 was used as a prototype to understand the mode of action of small molecule splicing mo…
View article: The diversity of splicing modifiers acting on A -1 bulged 5 -splice sites reveals rules for rational drug design
The diversity of splicing modifiers acting on A -1 bulged 5 -splice sites reveals rules for rational drug design Open
International audience
View article: Structure of a DNA G-quadruplex that Modulates SP1 Binding Sites Architecture in HIV-1 Promoter
Structure of a DNA G-quadruplex that Modulates SP1 Binding Sites Architecture in HIV-1 Promoter Open
View article: The diversity of splicing modifiers acting on A<sub>-1</sub>bulged 5’-splice sites reveals rules to guide rational design
The diversity of splicing modifiers acting on A<sub>-1</sub>bulged 5’-splice sites reveals rules to guide rational design Open
Non-physiological alternative splicing patterns are associated with numerous human diseases. Among the strategies developed to treat these diseases, small molecule splicing modifiers are emerging as a new class of RNA therapeutics. The SMN…
View article: Guidelines for G-quadruplexes: I. In vitro characterization
Guidelines for G-quadruplexes: I. In vitro characterization Open
View article: RNA G-quadruplex forming regions from SARS-2, SARS-1 and MERS coronoviruses
RNA G-quadruplex forming regions from SARS-2, SARS-1 and MERS coronoviruses Open
COVID-19 (Corona Virus Disease 2019), SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome) are infectious diseases each caused by coronavirus outbreaks. Small molecules and other therapeutics are rapidly bei…
View article: The Promoter Region of the Proto-Oncogene MST1R Contains the Main Features of G-Quadruplexes Formation
The Promoter Region of the Proto-Oncogene MST1R Contains the Main Features of G-Quadruplexes Formation Open
MST1R (RON) is a receptor of the MET tyrosine kinase receptor family involved in several cancers such as pancreas, breast, ovary, colon, and stomach. Some studies have shown that overexpression of MST1R increases the migratory and invasive…
View article: G-quadruplex structure of the <i>C. elegans</i> telomeric repeat: a two tetrads basket type conformation stabilized by a non-canonical C–T base-pair
G-quadruplex structure of the <i>C. elegans</i> telomeric repeat: a two tetrads basket type conformation stabilized by a non-canonical C–T base-pair Open
The Caenorhabditis elegans model has greatly contributed to the understanding of the role of G-quadruplexes in genomic instability. The GGCTTA repeats of the C. elegans telomeres resemble the GGGTTA repeats of the human telomeres. However,…
View article: hnRNPA1/UP1 Unfolds <i>KRAS</i> G-Quadruplexes and Feeds a Regulatory Axis Controlling Gene Expression
hnRNPA1/UP1 Unfolds <i>KRAS</i> G-Quadruplexes and Feeds a Regulatory Axis Controlling Gene Expression Open
Recent studies have proven that the genetic landscape of pancreatic cancer is dominated by the KRAS oncogene. Its transcription is controlled by a G-rich motif (called 32R) located immediately upstream of the TSS. 32R may fold into …
View article: Structure of two G-quadruplexes in equilibrium in the KRAS promoter
Structure of two G-quadruplexes in equilibrium in the KRAS promoter Open
KRAS is one of the most mutated oncogenes and still considered an undruggable target. An alternative strategy would consist in targeting its gene rather than the protein, specifically the formation of G-quadruplexes (G4) in its promoter. G…
View article: Etudes structurales par RMN des acides nucléiques G-quadruplexes de KRAS et leur interaction avec des ligands.
Etudes structurales par RMN des acides nucléiques G-quadruplexes de KRAS et leur interaction avec des ligands. Open
L'oncogène KRAS code pour une protéine GTPasique hautement mutée qui agit comme un « interrupteur » entre des états actifs et inactifs, un mécanisme important dans les processus comme la réplication ou la prolifération cellulaire. Quand il…
View article: High-resolution three-dimensional NMR structure of the KRAS proto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation
High-resolution three-dimensional NMR structure of the KRAS proto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation Open
Non-canonical base pairing within guanine-rich DNA and RNA sequences can produce G-quartets, whose stacking leads to the formation of a G-quadruplex (G4). G4s can coexist with canonical duplex DNA in the human genome and have been suggeste…
View article: 1H, 13C, and 15N resonance assignments of a 22mer G-quadruplex forming within KRAS oncogene promoter region at physiological temperature
1H, 13C, and 15N resonance assignments of a 22mer G-quadruplex forming within KRAS oncogene promoter region at physiological temperature Open
View article: NMR And Biophysical Studies Of G-Quadruplex DNA Within The KRAS Proto-Oncogene Promoter Region
NMR And Biophysical Studies Of G-Quadruplex DNA Within The KRAS Proto-Oncogene Promoter Region Open
The role of G-quadruplexes (G4) which can coexist with canonical duplex DNA in the human genome is still largely unknown. Although G4s are found throughout the entire genome, much of the attention have been invested in promotor regions of …
View article: NMR chemical shift assignments of a 22mer G-quadruplex formed within the KRAS proto-oncogene promoter region
NMR chemical shift assignments of a 22mer G-quadruplex formed within the KRAS proto-oncogene promoter region Open