Julien Senécal
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View article: Fidaxomicin to prevent recurrent <i>Clostridioides difficile</i>: what will it cost in the USA and Canada?
Fidaxomicin to prevent recurrent <i>Clostridioides difficile</i>: what will it cost in the USA and Canada? Open
Importance Recent changes in guidelines for managing Clostridioides difficile infections (CDI) have placed fidaxomicin as a first-line treatment. Objective To estimate the net cost of first-line fidaxomicin compared to vancomycin in the Am…
View article: Staphylococcus aureus bacteremia mortality across country income groups: A secondary analysis of a systematic review
Staphylococcus aureus bacteremia mortality across country income groups: A secondary analysis of a systematic review Open
In SAB studies, LMIC are poorly represented. In-hospital mortality was significantly higher in MIC than in HIC. Research should be conducted in LMIC to characterize differences in care processes driving the mortality gap.
View article: Remdesivir for the treatment of COVID-19: a systematic review and meta-analysis
Remdesivir for the treatment of COVID-19: a systematic review and meta-analysis Open
View article: What Is the Optimal Follow-up Length for Mortality in <i>Staphylococcus aureus</i> Bacteremia? Observations From a Systematic Review of Attributable Mortality
What Is the Optimal Follow-up Length for Mortality in <i>Staphylococcus aureus</i> Bacteremia? Observations From a Systematic Review of Attributable Mortality Open
Background Deaths following Staphylococcus aureus bacteremia (SAB) may be related or unrelated to the infection. In SAB therapeutics research, the length of follow-up should be optimized to capture most attributable deaths and minimize non…
View article: How Generalizable Are Randomized Controlled Trials (RCTs) in <i>Staphylococcus aureus</i> Bacteremia? A Description of the Mortality Gap Between RCTs and Observational Studies
How Generalizable Are Randomized Controlled Trials (RCTs) in <i>Staphylococcus aureus</i> Bacteremia? A Description of the Mortality Gap Between RCTs and Observational Studies Open
In Staphylococcus aureus bacteremia, mortality rates in randomized controlled trials (RCTs) are consistently lower than observational studies. Stringent eligibility criteria and omission of early deaths in RCTs contribute to this mortality…
View article: Remdesivir for the Treatment of COVID-19: An Updated Systematic Review and Meta-Analysis
Remdesivir for the Treatment of COVID-19: An Updated Systematic Review and Meta-Analysis Open
Background The benefits of remdesivir in the treatment of hospitalized patients with Covid-19 remain debated with the National Institutes of Health and the World Health Organization providing contradictory recommendations for and against u…
View article: Fidaxomicin as first line: What will it cost in the USA and Canada?
Fidaxomicin as first line: What will it cost in the USA and Canada? Open
Importance Recent changes in the Infectious Diseases and Healthcare Epidemiology Societies of America (IDSA-SHEA) guidelines for managing Clostridioides difficile infections (CDI) have placed fidaxomicin as first-line treatment. Objective …
View article: On the Treatment of <i>Pneumocystis jirovecii</i> Pneumonia: Current Practice Based on Outdated Evidence
On the Treatment of <i>Pneumocystis jirovecii</i> Pneumonia: Current Practice Based on Outdated Evidence Open
Pneumocystis jirovecii pneumonia (PCP) is a common opportunistic infection causing more than 400000 cases annually worldwide. Although antiretroviral therapy has reduced the burden of PCP in persons with human immunodeficiency virus (HIV),…
View article: Ongoing Citations of a Retracted Study Involving Cardiovascular Disease, Drug Therapy, and Mortality in COVID-19
Ongoing Citations of a Retracted Study Involving Cardiovascular Disease, Drug Therapy, and Mortality in COVID-19 Open
This quality improvement study examines the continued citations of a widely publicized retracted article on COVID-19.
View article: The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation
The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation Open
View article: p66ShcA functions as a contextual promoter of breast cancer metastasis
p66ShcA functions as a contextual promoter of breast cancer metastasis Open
Background The p66ShcA redox protein is the longest isoform of the Shc1 gene and is variably expressed in breast cancers. In response to a variety of stress stimuli, p66ShcA becomes phosphorylated on serine 36, which allows it to transloca…
View article: MOESM5 of p66ShcA functions as a contextual promoter of breast cancer metastasis
MOESM5 of p66ShcA functions as a contextual promoter of breast cancer metastasis Open
Additional file 5: Figure S5. p66ShcA does not alter the mesenchymal properties of 4T1-derived triple negative breast cancers. (A) Immunoblot analysis of whole cell lysates isolated from 4T1-537 parental, p66-CR (VC), p66-CR (WT) and p66-C…
View article: Immature Low-Density Neutrophils Exhibit Metabolic Flexibility that Facilitates Breast Cancer Liver Metastasis
Immature Low-Density Neutrophils Exhibit Metabolic Flexibility that Facilitates Breast Cancer Liver Metastasis Open
Neutrophils are phenotypically heterogeneous and exert either anti- or pro-metastatic functions. We show that cancer-cell-derived G-CSF is necessary, but not sufficient, to mobilize immature low-density neutrophils (iLDNs) that promote liv…