Explanipedia

455 Beyond Immunity: TEC and JAK3 Kinase Activation in Melanocytes Drives Inflammation in Vitiligo Open

C. Avril, Julien Sénéschal · 2025

Treatment of vitiligo with ruxolitinib cream in the TRuE-V1 and TRuE-V2 studies: a plain language summary of publication Open

David Rosmarin, Thierry Passeron, Amit G. Pandya, Pearl Grimes, John E. Harris , et al. · 2025

Summary What is this summary about? • This is a summary of a research article published in a medical journal that describes the main results from two studies called TRuE-V1 and TRuE-V2 • These studies looked at the use of ruxolitinib cream…

Personalized medicine in vitiligo: A guide for daily practice Open

Reinhart Speeckaert, Julien Sénéschal, Albert Wolkerstorfer, Nanja van Geel · 2025

Vitiligo is a chronic autoimmune depigmenting disorder with a complex clinical course and highly heterogeneous therapeutic response. Many disease‐specific and patient‐related factors determine the best personalized management in vitiligo. …

Suicidal ideation in patients with atopic dermatitis: A case‐control study on 23,191 adults Open

Julien Sénéschal, Bruno Halioua, Jerry Tan, Chaoying Gu, Thomas A. Luger , et al. · 2025

International audience

International insights into bullying in patients with atopic dermatitis: Global trends and key predictors Open

Roni P. Dodiuk‐Gad, Roberto Takaoka, L. Misery, Jerry Tan, Chaoying Gu , et al. · 2025

International audience

Atopic dermatitis beyond the skin: Characterizing skin pain in the “Scars of Life” study Open

Jonathan I. Silverberg, Roberto Takaoka, Jerry Tan, Thomas Luger, Chaoying Gu , et al. · 2025

Assessment of vitiligo in clinical practice: a cross-sectional survey among experts Open

Jolien Duponselle, Marlide R. Jukema, Albert Wolkerstorfer, Khaled Ezzedine, Iltefat Hamzavi , et al. · 2025

This study shows similarities but also remarkable differences in assessed outcomes compared to the CDS for clinical trials. These results serve as a preparatory step toward developing a COS for clinical practice with the involvement of exp…

Hyperpigmentation disorders: A comprehensive analysis in a worldwide large‐scale study on 50,552 individuals Open

Charbel Skayem, Bruno Halioua, M. Saint Aroman, Yaron Ben Hayoun, Catherine Baissac , et al. · 2025

Regulatory T Cell Dysregulation in Vitiligo: A Meta‐Analysis and Systematic Review of Immune Mechanisms and Therapeutic Perspectives Open

G. Rozenbaum Lerner, Maria Nikolaou, Corinne I. Stoffel, Eloi Schmauch, Thomas M. Kündig , et al. · 2025

Vitiligo is an autoimmune disorder marked by the progressive loss of skin melanocytes, increasingly linked to immune dysregulation as a key driver of disease onset and progression. Regulatory T (Treg) cells are essential for maintaining im…

Evaluation of the repigmentation of facial vitiligo using an <span>AI</span> algorithm in a phase 2 study Open

Capucine Defrance, Ribal Merhi, Nicolas Andreu, Martin Hagedorn, Dirk Hillmer , et al. · 2025

Clinical heterogeneity in vitiligo: Identification of clinical markers based patient clusters Open

L. Galissi, Tina J. Benoit, Ribal Merhi, Claire Drullion, Nicolas Andreu , et al. · 2025

Background Vitiligo (non‐segmental) is a chronic autoimmune skin disease leading to white patches. Although vitiligo has been delineated previously, the endophenotypes of the disease are still to be defined. Objective The aim of this study…

Alopecia areata and ritlecitinib: Unravelling response trajectories Open

Julien Sénéschal · 2025

Real-World Evidence for Baricitinib in the Treatment of Atopic Dermatitis and Alopecia Areata: Systematic Literature Review 2020–2023 Open

Julien Sénéschal, Lgnasi Figueras Nart, Silvia Sabatino, M. Papadimitropoulos, Srishti Dabral , et al. · 2025

Overall, baricitinib consistently improved the signs and symptoms of AD in patients receiving baricitinib in real-world settings, was effective for the treatment of AA in both adult and paediatric patients and was associated with improveme…

Atopic dermatitis starting in childhood has a stronger impact on adults: results from the ‘Scars of Life’ international project in 27 countries Open

Jonathan I. Silverberg, Roni P. Dodiuk‐Gad, Roberto Takaoka, Jerry Tan, Chaoying Gu , et al. · 2025

Childhood-onset atopic dermatitis (AD) has a profound and lasting psychosocial impact compared with adult-onset AD. This study highlights higher stigmatization scores and greater relational, social and professional challenges in individual…

Quality Analysis of Measurement Properties of Patient‐Reported Outcome Measures for Vitiligo and of the Studies Assessing Them: A Systematic Review Open

Jolien Duponselle, Sandrine Herbelet, Liesbeth Delbaere, Zoë De Schryver, Caroline B. Terwee , et al. · 2025

Evaluating measurement properties (MPs) of Patient Reported Outcome Measures (PROMs) in vitiligo is essential for evidence‐based recommendations and identifying research gaps. This study assesses the quality of PROMs used in vitiligo. A sy…

A Quality Analysis of the Measurement Properties of the Clinician-Reported Outcome Measures for Vitiligo and of the Studies Assessing Them: A Systematic Review Open

Jolien Duponselle, Sandrine Herbelet, Liesbeth Delbaere, Zoë De Schryver, Maxine Forman , et al. · 2025

Background/Objective: Evaluating the measurement properties (MPs) of Clinician-Reported Outcome Measures (ClinROMs) is crucial for selecting appropriate instruments for vitiligo assessment. This review critically appraises the existing evi…

Baseline Characteristics and Treatment Patterns of Patients with Atopic Dermatitis Treated with Oral Systemic Therapies: An Interim Analysis of the AD-REAL Study Open

Matthias Augustin, E. Serra‐Baldrich, Julien Sénéschal, Susanne Grond, Αναστασία Λαμπροπούλου , et al. · 2025

Efficacy and Safety of Ruxolitinib Cream in Vitiligo by Patient Characteristic Subgroups: Descriptive Pooled Analysis From Two Phase 3 Studies Open

Julien Sénéschal, Albert Wolkerstorfer, Seemal R. Desai, Pearl Grimes, Khaled Ezzedine , et al. · 2025

Real‐life effectiveness and safety of baricitinib in adults with alopecia areata: A multicentre study Open

A Mourtada, C. Douarec, Matthieu Wargny, V. Hébert, Z. Reguiaï , et al. · 2025

Long-Term Disease Control and Minimal Disease Activity of Head and Neck Atopic Dermatitis in Patients Treated with Tralokinumab up to 4 Years Open

Raj Chovatiya, Simone Ribero, Andreas Wollenberg, Chang Ook Park, Juan Francisco Silvestre , et al. · 2025

Refractory anogenital Hailey‐Hailey disease successfully treated with topical ruxolitinib Open

Sandra Ly, M. Beylot‐Barry, Julien Sénéschal · 2025

Relative Impact of Monotherapies for Vitiligo: A Network Meta‐Analysis Study Open

Aditya K. Gupta, Mary A. Bamimore, Julien Sénéschal, Vincent Piguet, Mesbah Talukder · 2025

Background Vitiligo, a stigmatizing condition characterized by patchy depigmented skin, has an estimated global prevalence of 0.36%. This condition is a risk factor for anxiety, depression, and even suicidal ideation. Hitherto, no network …

The Impact of Atopic Dermatitis on Employment and Productivity: A French Study Open

Khaled Ezzedine, Julien Sénéschal, Florence Corgibet, Bruno Halioua, Francesca Sampogna , et al. · 2025

International audience

Oral Ivermectin Versus 5% Permethrin Cream to Treat Children and Adults with Classic Scabies: A Cluster-Randomised Clinical Trial Open

F. Boralévi, Gérard Simon, Charlotte Bernigaud, Jennifer Brun, E. Goujon , et al. · 2025

Chronic Hand Eczema is a Type 2 Disease: Evidences from Integrated Clinical Trial and Molecular Profiling Open

M. Tauber, P. Gery, A. Du‐Thanh, Emilie Bérard, Fatma Jendoubi , et al. · 2024

Background. Chronic hand eczema (CHE) is a debilitating skin condition characterized by pain, itch, and chronic inflammation, with a complex multifactorial origin. Its diverse presentations, including overlapping traits of atopic dermatiti…

Effect of Therapeutic Patient Education in Adults with Atopic Dermatitis: Analysis of Efficacy and Treatment Needs Open

Marine Fargeas, Mathieu Fauvernier, M. Tauber, Julien Sénéschal, V. Verdú , et al. · 2024

In the era of biological treatments and small molecules, this study assessed therapeutic patient education (TPE) in managing adult atopic dermatitis (AD), focusing on disease severity, quality of life, and the use of systemic treatments. T…

Comorbidity burden on mortality in patients with systemic sclerosis Open

Thomas Fauthoux, Damien Brisou, Estibaliz Lazaro, Julien Sénéschal, J. Constans , et al. · 2024

Introduction Systemic sclerosis (SSc) is a serious life-threatening tissue disease. A significant aspect of its mortality arises from comorbid conditions. Our study aimed at mapping out the prevalence of these comorbidities and their relat…

Sexual impairment in patients with atopic dermatitis Open

L. Misery, Julien Sénéschal, Florence Corgibet, Bruno Halioua, Francesca Sampogna , et al. · 2024

Adults with atopic dermatitis (AD) frequently experience considerable sexual health issues, affecting their overall quality of life. Our study, involving a representative sample of the French population, highlights the prevalence of sexual…

Repigmentation by body region in patients with vitiligo treated with ruxolitinib cream over 52 weeks Open

Thierry Passeron, John E. Harris, Amit G. Pandya, Julien Sénéschal, Pearl Grimes , et al. · 2024

International audience

Real-life management of atopic dermatitis patients with an inadequate response to on-label use of dupilumab Open

Rémi Strizzolo, Julien Sénéschal, A. Soria, D. Staumont‐Sallé, S. Barbarot , et al. · 2024

In patients with moderate to severe atopic dermatitis (AD) showing an inadequate response to dupilumab 300mg/2weeks, few real-life studies reported the response to alternative regimen maintaining dupilumab. To assess and analyze the respon…

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